Molecular Engineering of Pericellular Microniche via Biomimetic Proteoglycans Modulates Cell Mechanobiology

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

(2021) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycans in Biomedicine: Resurgence of an Underexploited Class of ECM Molecules

(2020) Tanaya Walimbe et al.   Frontiers in Pharmacology

Early Changes in Cartilage Pericellular Matrix Micromechanobiology Portend the Onset of Post-Traumatic Osteoarthritis

(2020) Daphney R. Chery et al.   Acta Biomaterialia

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

(2020) Sylvie Brassart-Pasco et al.   Frontiers in Oncology

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

(2020) Leonhard Möckl   Frontiers in Cell and Developmental Biology

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

(2020) Tian Jin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Decorin regulates cartilage pericellular matrix micromechanobiology

(2020) Daphney R. Chery et al.   MATRIX BIOLOGY

Biomimetic proteoglycans diffuse throughout articular cartilage and localize within the pericellular matrix

(2019) Evan R. Phillips et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix

(2019) Biao Han et al.   ACS Nano

Aggrecan-like biomimetic proteoglycans (BPGs) composed of natural chondroitin sulfate bristles grafted onto a poly(acrylic acid) core for molecular engineering of the extracellular matrix

(2018) K. Prudnikova et al.   Acta Biomaterialia

Osteoarthritis as a disease of the cartilage pericellular matrix

(2018) Farshid Guilak et al.   MATRIX BIOLOGY

MMP-Responsive ‘Smart’ Drug Delivery and Tumor Targeting

(2018) Qing Yao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

(2018) Nikos K. Karamanos et al.   CHEMICAL REVIEWS

Bi-directional cell-pericellular matrix interactions direct stem cell fate

(2018) Silvia A. Ferreira et al.   Nature Communications

Biomimetic proteoglycans can molecularly engineer early osteoarthritic cartilage in vivo

(2018) Evan R. Phillips et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis

(2017) B. Doyran et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of Hydrogel Stiffness and Extracellular Compositions on Modulating Cartilage Regeneration by Mixed Populations of Stem Cells and Chondrocytes In Vivo

(2016) Tianyi Wang et al.   TISSUE ENGINEERING PART A

Biomimetic Molecules Lower Catabolic Expression and Prevent Chondroitin Sulfate Degradation in an Osteoarthritic ex Vivo Model

(2016) Shaili Sharma et al.   ACS Biomaterials-Science & Engineering

Biomimetic Molecules Lower Catabolic Expression and Prevent Chondroitin Sulfate Degradation in an Osteoarthritic ex Vivo Model

(2016) Shaili Sharma et al.   ACS Biomaterials Science & Engineering

Extracellular Processing of the Cartilage Proteoglycan Aggregate and Its Effect on CD44-mediated Internalization of Hyaluronan

(2015) Ben T. Danielson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular Adhesion between Cartilage Extracellular Matrix Macromolecules

(2014) Fredrick P. Rojas et al.   BIOMACROMOLECULES

Calcium signaling as a novel method to optimize the biosynthetic response of chondrocytes to dynamic mechanical loading

(2014) Joanna F. Weber et al.   Biomechanics and Modeling in Mechanobiology

The structure and function of the pericellular matrix of articular cartilage

(2014) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Perlecan-Containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-Canalicular System

(2013) Bin Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Atomic force microscopy reveals regional variations in the micromechanical properties of the pericellular and extracellular matrices of the meniscus

(2013) Johannah Sanchez-Adams et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage

(2013) R.E. Wilusz et al.   OSTEOARTHRITIS AND CARTILAGE

Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains

(2012) Hsu-Yi Lee et al.   JOURNAL OF STRUCTURAL BIOLOGY

Synthesis and characterization of an aggrecan mimic

(2011) Jonathan C. Bernhard et al.   Acta Biomaterialia

Nanomechanics of the Cartilage Extracellular Matrix

(2011) Lin Han et al.   Annual Review of Materials Research

Collagen-Binding Peptidoglycans Inhibit MMP Mediated Collagen Degradation and Reduce Dermal Scarring

(2011) Kate Stuart et al.   PLoS One

Spatial Mapping of the Biomechanical Properties of the Pericellular Matrix of Articular Cartilage Measured In Situ via Atomic Force Microscopy

(2010) Eric M. Darling et al.   BIOPHYSICAL JOURNAL

Cartilage Aggrecan Can Undergo Self-Adhesion

(2008) Lin Han et al.   BIOPHYSICAL JOURNAL

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY