Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles

A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

(2021) Wenbo Niu et al.   NANO LETTERS

Extracellular vesicles as a drug delivery system:A systematic review of preclinical studies

(2021) Pol Escudé Martinez de Castilla et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesenchymal stem cell-derived extracellular vesicles in the failing heart: past, present, and future

(2021) Catherine Karbasiafshar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling

(2021) Shaojun Pan et al.   BIOMATERIALS

Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

(2021) Morteza Heidarzadeh et al.   Cell and Bioscience

Biodistribution of extracellular vesicles following administration into animals: A systematic review

(2021) Matthew Kang et al.   Journal of Extracellular Vesicles

Integrin Signaling in Glioma Pathogenesis: From Biology to Therapy

(2020) Aleksandra Ellert-Miklaszewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Exosomes in the Progression, Diagnosis, and Treatment of Gliomas

(2020) Ji Shi et al.   MEDICAL SCIENCE MONITOR

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

(2019) Huixin Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

(2019) Gulsah Erel-Akbaba et al.   ACS Nano

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

(2019) Dongsic Choi et al.   ACS Nano

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma

(2019) Peng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

(2019) Anna Galstyan et al.   Nature Communications

Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

(2019) Shaojun Pan et al.   BIOMATERIALS

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

Immunotherapy: Cancer immunotherapy and the value of cure

(2018) Joseph C. Del Paggio   Nature Reviews Clinical Oncology

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

Safety of combining radiotherapy with immune-checkpoint inhibition

(2018) William L. Hwang et al.   Nature Reviews Clinical Oncology

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Advances in Radiotherapy for Glioblastoma

(2018) Justin Mann et al.   Frontiers in Neurology

PD-1 inhibition has only limited clinical benefit in patients with recurrent high-grade glioma

(2018) Sylvia C. Kurz et al.   NEUROLOGY

Comparative analysis of human embryonic stem cell‑derived neural stem cells as an in vitro human model

(2017) Jung‑Hwa Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors

(2017) S. Quader et al.   JOURNAL OF CONTROLLED RELEASE

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

(2017) Aisling J. O’Loughlin et al.   MOLECULAR THERAPY

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

(2017) Miles A. Miller et al.   Science Translational Medicine

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

(2017) Kasper Bendix Johnsen et al.   Scientific Reports

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

(2016) Xiaohong Wang et al.   CANCER RESEARCH

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: Expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering

(2015) Filipa Pires et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Radiotherapy combined with immune checkpoint blockade immunotherapy: Achievements and challenges

(2015) Feifei Teng et al.   CANCER LETTERS

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Radiation and immunotherapy: a synergistic combination

(2013) Anusha Kalbasi et al.   JOURNAL OF CLINICAL INVESTIGATION

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY