First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy

N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer

(2021) Senxu Lu et al.   Journal of Hematology & Oncology

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

(2020) Kyuho Han et al.   NATURE

Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism

(2020) Charlotte Dahlem et al.   Cancers

A large-scale binding and functional map of human RNA-binding proteins

(2020) Eric L. Van Nostrand et al.   NATURE

Fragment-based discovery of a qualified hit targeting the Latency-associated Nuclear Antigen of the oncogenic Kaposi’s Sarcoma-associated Herpesvirus/Human Herpesvirus 8

(2019) Philine Elea Kirsch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

Cancer the‘RBP’eutics–RNA-binding proteins as therapeutic targets for cancer

(2019) Shakur Mohibi et al.   PHARMACOLOGY & THERAPEUTICS

Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3

(2019) Tim Schneider et al.   Nature Communications

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

(2019) Jeetayu Biswas et al.   Nature Communications

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway

(2019) Xiaodong Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

(2019) Yun Wang et al.   Molecular Cancer

Overexpression of p62/IMP2 can Promote Cell Migration in Hepatocellular Carcinoma via Activation of the Wnt/β-Catenin Pathway

(2019) Mengtao Xing et al.   Cancers

Investigating Protein-Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy

(2018) Walter Becker et al.   CHEMPHYSCHEM

The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

(2018) Junguo Cao et al.   Stem Cells International

Structural basis of IMP3 RRM12 recognition of RNA

(2018) Min Jia et al.   RNA

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum

(2018) Rineke Steenbergen et al.   Scientific Reports

Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts

(2017) Rita Fior et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer

(2017) Sonja M. Kessler et al.   Oncotarget

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

(2017) Ning Dai et al.   eLife

Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies

(2016) Yuxin Ye et al.   FEBS LETTERS

IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering withRAF-1degradation by miR-195

(2016) Song Ye et al.   FEBS LETTERS

Discovery of the first small-molecule CsrA–RNA interaction inhibitors using biophysical screening technologies

(2016) Christine K Maurer et al.   Future Medicinal Chemistry

DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up

(2016) Elisabetta Bigagli et al.   CELLULAR ONCOLOGY

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

(2016) Anne E. Conway et al.   Cell Reports

IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins

(2015) Ning Dai et al.   Cell Metabolism

A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene

(2015) Ahmed El-Shamy et al.   JOURNAL OF HEPATOLOGY

IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype

(2015) S M Kessler et al.   Cell Death & Disease

Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2014) Sonja Kessler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TheIGF2mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis

(2014) Stephan Laggai et al.   JOURNAL OF LIPID RESEARCH

Novel small molecule inhibitors targeting the “switch region” of bacterial RNAP: Structure-based optimization of a virtual screening hit

(2013) J. Henning Sahner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IGF2BP2-2 as a promoter of NAFLD and HCC?

(2013) Yvette Simon et al.   GUT

Discovery of Novel Bacterial RNA Polymerase Inhibitors: Pharmacophore-Based Virtual Screening and Hit Optimization

(2013) Stefan Hinsberger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Humoral Autoimmune Response to IGF2 mRNA-Binding Protein (IMP2/p62) and Its Tissue-Specific Expression in Colon Cancer

(2013) W. Liu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling

(2012) Sonja M. Kessler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

(2012) Jessica L. Bell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control

(2012) V. L. Patel et al.   GENES & DEVELOPMENT

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding

(2011) Aldino Viegas et al.   JOURNAL OF CHEMICAL EDUCATION

Analysis of protein-ligand interactions by fluorescence polarization

(2011) Ana M Rossi et al.   Nature Protocols

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

ZBP1 recognition of  -actin zipcode induces RNA looping

(2010) J. A. Chao et al.   GENES & DEVELOPMENT

Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype

(2010) Elisabeth Tybl et al.   JOURNAL OF HEPATOLOGY