Engineered Repeat Protein Hybrids: The New Horizon for Biologic Medicines and Diagnostic Tools

Bottom-up de novo design of functional proteins with complex structural features

(2021) Che Yang et al.   Nature Chemical Biology

Genetically encodable materials for non-invasive biological imaging

(2021) Arash Farhadi et al.   NATURE MATERIALS

FDA approves 100th monoclonal antibody product

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

(2020) Greta Giordano-Attianese et al.   NATURE BIOTECHNOLOGY

White-emitting Protein-Metal Nanocluster Phosphors for Highly Performing Biohybrid Light-Emitting Diodes

(2020) Antonio Aires et al.   NANO LETTERS

De novo protein design enables the precise induction of RSV-neutralizing antibodies

(2020) Fabian Sesterhenn et al.   SCIENCE

Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery

(2020) Lukas Becker et al.   BMC BIOLOGY

Protein Design for the Synthesis and Stabilization of Highly Fluorescent Quantum Dots

(2020) Antonio Aires et al.   CHEMISTRY OF MATERIALS

Generation and design of nanobodies

(2020) Serge Muyldermans   FEBS Journal

Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells

(2020) Zhaodi Jiang et al.   NATURE METHODS

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

(2020) Jiang Yang et al.   Nature Biomedical Engineering

Animal-free alternatives and the antibody iceberg

(2020) Alison Gray et al.   NATURE BIOTECHNOLOGY

LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions

(2020) Curran Oi et al.   Communications Biology

First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors

(2020) Richard D. Baird et al.   JOURNAL OF CLINICAL ONCOLOGY

Protein-based nanomaterials and nanosystems for biomedical applications: A review

(2020) Shichao Ding et al.   Materials Today

A simple approach to design proteins for the sustainable synthesis of metal nanoclusters

(2019) Antonio Aires et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy

(2019) Qian Chen et al.   ACS Applied Materials & Interfaces

Design and site-directed compartmentalization of gold nanoclusters within the intrasubunit interfaces of ferritin nanocage

(2019) Jiachen Zang et al.   JOURNAL OF NANOBIOTECHNOLOGY

C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action

(2019) David Bickel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Self-assembly of repeat proteins: Concepts and design of new interfaces

(2018) Daniel Sanchez-deAlcazar et al.   JOURNAL OF STRUCTURAL BIOLOGY

Reduction of cardiac TGFβ-mediated profibrotic events by inhibition of Hsp90 with engineered protein

(2018) R.A. Cáceres et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Observation of gold sub-nanocluster nucleation within a crystalline protein cage

(2017) Basudev Maity et al.   Nature Communications

Engineering gold-based radiosensitizers for cancer radiotherapy

(2017) Nirmal Goswami et al.   Materials Horizons

Assembly of designed protein scaffolds into monolayers for nanoparticle patterning

(2016) Sara H. Mejias et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Protein engineering strategies with potential applications for altering clinically relevant cellular pathways at the protein level

(2016) Lynne Regan et al.   Expert Review of Proteomics

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Bovine Serum Albulmin Protein-Templated Silver Nanocluster (BSA-Ag13): An Effective Singlet Oxygen Generator for Photodynamic Cancer Therapy

(2016) Yong Yu et al.   Advanced Healthcare Materials

Design of Protein–Peptide Interaction Modules for Assembling Supramolecular Structures in Vivo and in Vitro

(2015) Elizabeth B. Speltz et al.   ACS Chemical Biology

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

Designed Modular Proteins as Scaffolds To Stabilize Fluorescent Nanoclusters

(2015) Pierre Couleaud et al.   BIOMACROMOLECULES

Exploring the repeat protein universe through computational protein design

(2015) TJ Brunette et al.   NATURE

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

Protein-quantum dot nanohybrids for bioanalytical applications

(2015) Jeong Yu Lee et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

PET and NIR optical imaging using self-illuminating 64 Cu-doped chelator-free gold nanoclusters

(2014) Hao Hu et al.   BIOMATERIALS

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

(2014) Erik Procko et al.   CELL

Controlled nanometric fibers of self-assembled designed protein scaffolds

(2014) Sara H. Mejías et al.   Nanoscale

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display

(2013) Johannes Schilling et al.   JOURNAL OF MOLECULAR BIOLOGY

Nanostructured functional films from engineered repeat proteins

(2013) T. Z. Grove et al.   Journal of the Royal Society Interface

Hybrid gold–gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo

(2012) De-Hong Hu et al.   Nanoscale

Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries

(2012) L. Kummer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating repeat protein stability: The effect of individual helix stability on the collective behavior of the ensemble

(2011) Aitziber L. Cortajarena et al.   PROTEIN SCIENCE

Ultrasmall near-infrared gold nanoclusters for tumor fluorescence imaging in vivo

(2010) Xu Wu et al.   Nanoscale

Screening Libraries To Identify Proteins with Desired Binding Activities Using a Split-GFP Reassembly Assay

(2009) Meredith E. Jackrel et al.   ACS Chemical Biology

Designed Proteins To Modulate Cellular Networks

(2009) Aitziber L. Cortajarena et al.   ACS Chemical Biology

Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters

(2009) Jianping Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designing artificial enzymes by intuition and computation

(2009) Vikas Nanda et al.   Nature Chemistry

Designed TPR Modules as Novel Anticancer Agents

(2008) Aitziber L. Cortajarena et al.   ACS Chemical Biology

Protein- and Peptide-Directed Syntheses of Inorganic Materials

(2008) Matthew B. Dickerson et al.   CHEMICAL REVIEWS