Structure and functions of angiotensinogen

Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model

(2016) Takamitsu Saigusa et al.   FASEB JOURNAL

Angiotensinogen Exerts Effects Independent of Angiotensin IISignificance

(2015) Hong Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cys18-Cys137 Disulfide Bond in Mouse Angiotensinogen Does Not Affect AngII-Dependent Functions In Vivo

(2015) C. Wu et al.   HYPERTENSION

Deficiency of Angiotensinogen in Hepatocytes Markedly Decreases Blood Pressure in Lean and Obese Male MiceNovelty and Significance

(2015) Frederique Yiannikouris et al.   HYPERTENSION

Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life

(2015) Masashi Demura et al.   HYPERTENSION RESEARCH

Inactivation of adipose angiotensinogen reduces adipose tissue macrophages and increases metabolic activity

(2015) Monique J. LeMieux et al.   Obesity

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

(2014) Lijuan Wang et al.   HYPERTENSION RESEARCH

Establishing a Reliable Multiple Reaction Monitoring-Based Method for the Quantification of Obesity-Associated Comorbidities in Serum and Adipose Tissue Requires Intensive Clinical Validation

(2014) Andreas Oberbach et al.   JOURNAL OF PROTEOME RESEARCH

Constitutive activation of the renin-angiotensin system reduces visceral fat and improves glucose tolerance in mice

(2014) Guillaume A Favre et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Comparative Effects of the Renin–Angiotensin System Blockers on Nonalcoholic Fatty Liver Disease and Insulin Resistance in C57Bl/6 Mice

(2014) Eliete Dalla Corte Frantz et al.   Metabolic Syndrome and Related Disorders

Contributions of Leukocyte Angiotensin-Converting Enzyme to Development of Atherosclerosis

(2013) Xiaofeng Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension

(2013) Jeffrey Olearczyk et al.   HYPERTENSION RESEARCH

PD123319 Augments Angiotensin II-Induced Abdominal Aortic Aneurysms through an AT2 Receptor-Independent Mechanism

(2013) Alan Daugherty et al.   PLoS One

Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor

(2012) Candice M. Thomas et al.   CLINICAL SCIENCE

Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice

(2012) Frederique Yiannikouris et al.   HYPERTENSION

Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice

(2012) Hong Lu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Liver Angiotensinogen Is the Primary Source of Renal Angiotensin II

(2012) T. Matsusaka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regional Variation in Aortic AT1b Receptor mRNA Abundance Is Associated with Contractility but Unrelated to Atherosclerosis and Aortic Aneurysms

(2012) Aruna Poduri et al.   PLoS One

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice

(2011) Frederique Yiannikouris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis

(2011) Hong Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aliskiren and Valsartan Reduce Myocardial AT1 Receptor Expression and Limit Myocardial Infarct Size in Diabetic Mice

(2011) Yumei Ye et al.   CARDIOVASCULAR DRUGS AND THERAPY

Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice

(2011) Young Sun Kang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Adipose Tissue–Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy

(2010) Shintaro Yasue et al.   AMERICAN JOURNAL OF HYPERTENSION

Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts

(2010) J. H. M. van Esch et al.   CARDIOVASCULAR RESEARCH

The Brain Renin-Angiotensin System Controls Divergent Efferent Mechanisms to Regulate Fluid and Energy Balance

(2010) Justin L. Grobe et al.   Cell Metabolism

Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-Ay mice

(2010) Masaru Iwai et al.   JOURNAL OF HYPERTENSION

Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice

(2010) Yi-Fei Dong et al.   JOURNAL OF HYPERTENSION

A redox switch in angiotensinogen modulates angiotensin release

(2010) Aiwu Zhou et al.   NATURE

Dynamic Observation of Mechanically-Injured Mouse Femoral Artery Reveals an Antiinflammatory Effect of Renin Inhibitor

(2009) Jun Ino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aliskiren reduces body-weight gain, adiposity and plasma leptin during diet-induced obesity

(2009) Paula Stucchi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensinogen Delays Angiogenesis and Tumor Growth of Hepatocarcinoma in Transgenic Mice

(2009) F. Vincent et al.   CANCER RESEARCH

Deletion of angiotensin II type I receptor reduces hepatic steatosis

(2009) Yoshitaka Nabeshima et al.   JOURNAL OF HEPATOLOGY

A haplotype of human angiotensinogen gene containing −217A increases blood pressure in transgenic mice compared with −217G

(2008) Sudhir Jain et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Local adipose tissue renin-angiotensin system

(2008) Lisa A. Cassis et al.   CURRENT HYPERTENSION REPORTS

Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors

(2008) Florian Gembardt et al.   FASEB JOURNAL

Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance

(2008) A. P. Jayasooriya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA