Article
Peripheral Vascular Disease
Carmine Savoia, Carolina De Ciuceis, Anna Paini, Raffaella Carletti, Emanuele Arrabito, Carmine Nicoletti, Paolo Mercantini, Cira Di Gioia, Allegra Battistoni, Sarassunta Ucci, Antonio Filippini, Enrico Agabiti Rosei, Massimo Volpe, Maria L. Muiesan, Damiano Rizzoni, Massimo Salvetti
Summary: In this study, chronic treatment with the direct renin inhibitor aliskiren significantly improved vascular function in both resistance and conduit arteries of type two diabetic and hypertensive patients. Aliskiren restored endothelial function and induced a more prompt peripheral vasodilation, possibly through increased production of nitric oxide via enhanced expression and function of the active phosphorylated form of endothelial nitric oxide synthase, compared to ramipril.
JOURNAL OF HYPERTENSION
(2021)
Article
Transplantation
Sydney C. W. Tang, Kam Wa Chan, Dennis K. M. Ip, Desmond Y. H. Yap, Maggie K. M. Ma, Maggie M. Y. Mok, Gary C. W. Chan, Sidney Tam, Kar Neng Lai
Summary: This study aimed to investigate the renoprotective effect of aliskiren in nondiabetic chronic kidney disease patients. The results showed that aliskiren did not provide additional renoprotective benefit nor increased adverse events, except for a higher rate of hyperkalemia.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, Research & Experimental
Mohamed Essam, Nashwa Barakat, Ahmed Elkashef, Amira Awadalla, A. E. Behery, Mahmoud Abdel-Maboud
Summary: The study showed that aliskiren significantly improved renal function, reduced necrosis and inflammatory cell infiltration in the cortex and medulla during acute and chronic partial ureteral obstruction in rat solitary kidney. Aliskiren also upregulated BCL-2 and downregulated IL-6, TGF-beta 1, collagen I, and fibronectin gene expression, while increasing GSH and SOD activity and reducing MDA and NO activity, leading to a more renoprotective effect when administered for four weeks compared to two weeks.
Article
Neurosciences
Sami Alzarea, Hassan H. Alhassan, Abdulaziz Alzarea, Ziad H. Al-Oanzi, Muhammad Afzal
Summary: The study aims to determine the impact of renin inhibitor Aliskiren on lipopolysaccharide-induced depressive-like behavior and neuroinflammation in mice. The results demonstrate that Aliskiren can mitigate the negative effects of lipopolysaccharide on mouse behavior and brain inflammation.
Article
Medicine, Research & Experimental
Maliheh Entezari, Danial Hashemi, Afshin Taheriazam, Amirhossein Zabolian, Shima Mohammadi, Farima Fakhri, Mehrdad Hashemi, Kiavash Hushmandi, Milad Ashrafizadeh, Ali Zarrabi, Yavuz Nuri Ertas, Sepideh Mirzaei, Saeed Samarghandian
Summary: AMPK plays a crucial role in diabetes mellitus by promoting glucose metabolism, enhancing insulin sensitivity, inhibiting stress and cell death in beta cells, and improving diabetic complications in patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Erard Vergoten, Christian Bailly
Summary: The renin protein and ACE2 play crucial roles in regulating blood pressure and facilitating SARS-CoV-2 virus entry into host cells. Studies have shown that renin inhibitors like remikiren and aliskiren can interact with the viral main protease M-pro, suggesting potential antiviral effects. The binding of these inhibitors to M-pro suggests a promising avenue for drug development against COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Fanzhen Yu, Yilong Teng, Jiaqi Li, Shutong Yang, Zeng Zhang, Yanming He, Hongjie Yang, Chuan-Fan Ding, Ping Zhou
Summary: This study investigated the effects of FYGL on pancreatic functions and gene pathways in a T2D rat model. The results showed that FYGL positively regulated T2D-related pathways, improving hyperglycemia and hyperlipidemia. The recovery of pancreatic function suggested a crucial strategy for treating T2D.
Article
Gastroenterology & Hepatology
Alessia Ciancio, Davide G. Ribaldone, Anna Dotta, Chiara Giordanino, Marco Sacco, Sharmila Fagoonee, Rinaldo Pellicano, Giorgio M. Saracco
Summary: The study found that clearance of HCV by DAAs led to long-term improvement in glycometabolic control in diabetic patients, but diabetes still had a detrimental effect on the liver in cirrhotic patients.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Burak Andac, Eray Ozgun, Buket Yilmaz Bulbul, Serpil Yanik Colak, Mine Okur, Ali Cem Yekdes, Eftal Ocal, Mehmet Emin Tapan, Mehmet Celik
Summary: The study found no association between MG53 levels and T2DM or glycemic control in the studied population. Further clinical studies are needed to establish the link between MG53, insulin resistance, and glycemic control in a broader population.
Article
Chemistry, Medicinal
Daisuke Iijima, Hiroshi Sugama, Nobumasa Awai, Yoichi Takahashi, Yuko Togashi, Tohru Takebe, Jianshu Xie, Jingkang Shen, Ying Ke, Hidenori Akatsuka, Takayuki Kawaguchi, Kei Takedomi, Akiko Kashima, Masashi Nishio, Yosuke Inui, Hikaru Yoneda, Guangxin Xia, Toru Iijima
Summary: The renin-angiotensin-aldosterone system (RAAS) is crucial in blood pressure regulation, with renin being the initial and rate-limiting enzyme. A novel class of direct renin inhibitors (DRIs) composed of a 2-carbamoyl morpholine scaffold showed potent antihypertensive efficacy via oral administration in double transgenic mice.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Food Science & Technology
Faezeh Malakoti, Erfan Mohammadi, Mahsa Akbari Oryani, Darioush Shanebandi, Bahman Yousefi, Azadeh Salehi, Zatollah Asemi
Summary: MiRNAs play a role in the occurrence and development of diabetic complications by interacting with mRNA to prevent translation, and polyphenols are considered safe drugs for treating diabetic complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yueqiu Liu, Wen Zheng, Lu Zhang, Liqiang Hu, Xin Liu, Jingqiu Cheng, Guoliang Li, Meng Gong
Summary: This study investigated the hypoglycemic and metabolic effects of Ficus racemosa fruit in diabetic mice and explored its potential mechanisms using a metabolomics approach. The results showed that Ficus racemosa fruit could lower blood glucose levels and improve tissue lesions, primarily by altering amino acid, organic acid, and nucleotide metabolism.
Review
Pharmacology & Pharmacy
Dongning Liang, Hanwen Mai, Fangyi Ruan, Haiyan Fu
Summary: Triptolide (TP) shows significant efficacy in reducing albuminuria, urine albumin/urine creatinine ratio, total proteinuria, serum creatinine, and blood urea nitrogen in diabetic kidney disease (DKD) animals. When compared to renin-angiotensin system (RAS) inhibitors, TP demonstrates better results in reducing urine albumin/urine creatinine ratio and total proteinuria.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Chrong-Reen Wang, Hung-Wen Tsai
Summary: In this retrospective study, a reduction of insulin resistance was achieved in non-diabetic active RA patients following 24 weeks of TOF therapy.
WORLD JOURNAL OF DIABETES
(2022)
Article
Medicine, Research & Experimental
Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen
Summary: This study found that the antiviral drug acyclovir can improve insulin resistance by reducing blood lipids and oxidative stress, and increasing insulin sensitivity. Mechanistically, acyclovir stimulates pyruvate kinase M1 (PKM1) to activate the AMPK/SIRT1 signaling pathway, which could be a valuable target for developing new medications.
Article
Cardiac & Cardiovascular Systems
Hyeon Seok Hwang, Jin Sug Kim, Yang Gyun Kim, Yu Ho Lee, Dong-Young Lee, Shin Young Ahn, Ju-Young Moon, Sang-Ho Lee, Gang-Jee Ko, Kyung Hwan Jeong
Summary: In hemodialysis patients, circulating neprilysin levels were found to be positively correlated with left ventricular mass index and volumes, and negatively correlated with left ventricular ejection fraction. Higher levels of neprilysin independently predicted the occurrence of cardiovascular and cardiac events in these patients, highlighting the potential importance of neprilysin inhibition in reducing cardiovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Urology & Nephrology
Eunjung Cho, Soo Jeong Choi, Duk-Hee Kang, Kamyar Kalantar-Zadeh, Gang-Jee Ko
Summary: This review explores the impact of high-protein diets (HPDs) on kidney health, finding that HPDs are associated with a rapid decline in kidney function. The mechanism involves increased renal blood flow, glomerular hyperfiltration, and potential inflammation and glomerulosclerosis. Athletes and bodybuilders who follow HPDs long-term may be at a higher risk of developing HPD nephropathy.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2022)
Review
Biochemistry & Molecular Biology
Ji-Eun Kim, Jin-Sun Kim, Min-Jee Jo, Eunjung Cho, Shin-Young Ahn, Young-Joo Kwon, Gang-Jee Ko
Summary: This review summarizes the role of adipokines in the development of metabolic syndrome, with a focus on glucose homeostasis and lipid metabolism.
Article
Medicine, General & Internal
Eunjung Cho, Gang-Jee Ko
Summary: Contrast-induced nephropathy (CIN) is a form of kidney dysfunction that occurs after the administration of an iodinated contrast medium. Although this kidney dysfunction is typically temporary and reversible, it is the third most common cause of hospital-acquired acute kidney injury and is associated with increased morbidity and mortality. Elderly individuals, who often have multiple comorbidities, are particularly susceptible to this kidney injury, highlighting the importance of identifying its mechanisms and risk factors for optimal preventive management.
Article
Medicine, General & Internal
Jeong Ah Hwang, Younghoon Song, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang Jee Ko, Young Joo Kwon, Ji Eun Kim
Summary: This study found a U-shaped relationship between mortality and CCR levels in normal renal function, as well as an increased risk of mortality in CKD patients with elevated CCR.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Dae Kyu Kim, Gang Jee Ko, Yun Jin Choi, Kyung Hwan Jeong, Ju Young Moon, Sang Ho Lee, Hyeon Seok Hwang
Summary: Adequate glycemic control is crucial for improving clinical outcomes in hemodialysis patients with diabetes. This study found a linear relationship between HbA1c levels and the risk of all-cause mortality, with an earlier and more rapid increase in the risk of cardiovascular death.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Younghoon Song, Jeong Ah Hwang, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang Jee Ko, Young Joo Kwon, Ji Eun Kim
Summary: Obesity is associated with chronic kidney disease (CKD), and body composition metrics may provide more accurate predictions for CKD development.
Article
Geriatrics & Gerontology
Hyunsuk Kim, Mun Jung Ko, Chi-Yeon Lim, Eunjin Bae, Young Youl Hyun, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O. Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong
Summary: This study found that high physical activity is an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
Article
Medicine, General & Internal
Young-Ki Lee, Yang-Hyeon Kim, Do-Hyoung Kim, Jin-Heog Kim, Jeong-Hwan Lee, Ji Hyeon Park, Gang-Jee Ko, Won-Min Hwang, Hyo-Wook Gil, Young-Sun Kang, Kyu-Bok Jin, Jun-Young Do, Se-Joong Kim, Beom-Seok Kim, Ho Sik Shin
Summary: This study aimed to evaluate the implementation of an intervention to achieve shared decision making in patients' options for dialysis. The results showed that SDM was effective in deciding on dialysis treatment, and patients were satisfied with the decision-making process for dialysis methods.
Article
Multidisciplinary Sciences
Jeong Ah Hwang, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang-Jee Ko, Young Joo Kwon, Ji Eun Kim
Summary: This study aimed to identify the risk factors for high discordance in kidney function decline in identical twins. The results showed that blood hemoglobin level may be associated with individual differences in kidney function decline.
Article
Multidisciplinary Sciences
Kyung Don Yoo, Junhyug Noh, Wonho Bae, Jung Nam An, Hyung Jung Oh, Harin Rhee, Eun Young Seong, Seon Ha Baek, Shin Young Ahn, Jang-Hee Cho, Dong Ki Kim, Dong-Ryeol Ryu, Sejoong Kim, Chun Soo Lim, Jung Pyo Lee, Sung Gyun Kim, Gang Jee Ko, Jung Tak Park, Tae Ik Chang, Sungjin Chung, Jung Pyo Lee, Sang Ho Lee, Bum Soon Choi, Jin Seok Jeon, Sangheon Song, Dae Eun Choi, Woo Kyung Jung
Summary: This study evaluated the impact of fluid balance monitoring on the prognosis of patients with severe acute kidney injury. The results showed a marginal benefit of fluid balance for the control group after adjusting for confounding factors. The deep-learning model using recurrent neural networks achieved the best performance in prognosis assessment.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Je Hun Song, Eun Hee Park, Jinsuk Bae, Soon Hyo Kwon, Jang-Hee Cho, Byung Chul Yu, Miyeun Han, Sang Heon Song, Gang-Jee Ko, Jae Won Yang, Sungjin Chung, Yu Ah Hong, Young Youl Hyun, Eunjin Bae, In O. Sun, Hyunsuk Kim, Won Min Hwang, Sung Joon Shin, Woo Yeong Park, Hyoungnae Kim, Kyung Don Yoo
Summary: This study analyzed the levels of low-density lipoprotein cholesterol (LDL-C) in older Korean hemodialysis patients and their relationship with mortality. The results showed that elevated LDL-C levels were not associated with increased all-cause mortality in hemodialysis patients who had not previously received dyslipidemia treatment. However, lower LDL-C levels appeared to be associated with an unfavorable effect on all-cause mortality among high-risk hemodialysis patients.
Article
Genetics & Heredity
Ji-Eun Kim, Min-Jee Jo, Eunjung Cho, Shin-Young Ahn, Young-Joo Kwon, Jeong-An Gim, Gang-Jee Ko
Summary: This study aimed to explore the DNA methylation status associated with chronic kidney disease (CKD) and its development. The results showed significant correlations between methylation levels of certain CpG sites and the development of CKD. Further analysis revealed that the methylation status of specific genes was associated with the decline in kidney function. Therefore, DNA methylation is closely related to the development and deterioration of CKD.
Article
Biochemistry & Molecular Biology
Min Jee Jo, Ji Eun Kim, So Yon Bae, Eunjung Cho, Shin Young Ahn, Young Joo Kwon, Gang-Jee Ko
Summary: This study investigated the role of NRF2 in restoring kidney function after IRI in the aging kidney. The expression of NRF2 decreased significantly in the kidneys of old mice, and renal recovery after IRI was impaired in these mice. In NRF2 knockout mice, renal injury during the recovery phase after IRI was aggravated. These findings suggest that NRF2 may be a therapeutic target for the aging kidney.
Article
Urology & Nephrology
Byung Chul Yu, Miyeun Han, Gang-Jee Ko, Jae Won Yang, Soon Hyo Kwon, Sungjin Chung, Yu Ah Hong, Young Youl Hyun, Jang-Hee Cho, Kyung Don Yoo, Eunjin Bae, Woo Yeong Park, In O. Sun, Dongryul Kim, Hyunsuk Kim, Won Min Hwang, Sang Heon Song, Sung Joon Shin
Summary: Despite the use of shared decision-making (SDM) in practice, physicians in Korea believe that it is not being implemented properly. Lack of time, educational materials, and training on SDM are identified as the main obstacles to its appropriate application.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)