Activins in reproductive biology and beyond

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

(2015) Rebecca Lim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer

(2015) Yosuke Togashi et al.   CANCER LETTERS

Activin signalling and pre-eclampsia: From genetic risk to pre-symptomatic biomarker

(2015) Rachel D. Williamson et al.   CYTOKINE

Overexpression of activin-A and -B in malignant mesothelioma – Attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth

(2015) Jenni A. Tamminen et al.   EXPERIMENTAL CELL RESEARCH

The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology

(2015) Charles L Hardy et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of Activin A and Myostatin in Human Cancer Cachexia

(2015) Audrey Loumaye et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activin-βC modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice

(2015) Francesco Elia Marino et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Development of Novel Activin-Targeted Therapeutics

(2015) Justin L Chen et al.   MOLECULAR THERAPY

Activin A supplement in the hESCs culture enhances the endoderm differentiation efficiency

(2014) Shuren Guo et al.   CELL BIOLOGY INTERNATIONAL

Combinatorial actions of Tgf  and Activin ligands promote oligodendrocyte development and CNS myelination

(2014) D. J. Dutta et al.   DEVELOPMENT

The inhibin/activin signalling pathway in human gonadal and adrenal cancers

(2014) Francesco Elia Marino et al.   MOLECULAR HUMAN REPRODUCTION

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

(2014) Rajasekhar N V S Suragani et al.   NATURE MEDICINE

Serum Activin A and Follistatin Levels in Gestational Diabetes and the Association of the Activin A-Follistatin System with Anthropometric Parameters in Offspring

(2014) Silvia Näf et al.   PLoS One

The Generation of Definitive Endoderm from Human Embryonic Stem Cells is Initially Independent from Activin A but Requires Canonical Wnt-Signaling

(2014) Ortwin Naujok et al.   Stem Cell Reviews and Reports

Female Aging Alters Expression of Human Cumulus Cells Genes that Are Essential for Oocyte Quality

(2014) Tamadir Al-Edani et al.   Biomed Research International

Follistatin, an Activin Antagonist, Ameliorates Renal Interstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction

(2014) Akito Maeshima et al.   Biomed Research International

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion

(2014) Holli Loomans et al.   Cancers

FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors

(2013) Jung-Chien Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The activins and their binding protein, follistatin—Diagnostic and therapeutic targets in inflammatory disease and fibrosis

(2013) M.P. Hedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Activin A and Follistatin as Biomarkers for Ectopic Pregnancy and Missed Abortion

(2013) Alexandros Daponte et al.   DISEASE MARKERS

Elevated expression of activins promotes muscle wasting and cachexia

(2013) Justin L. Chen et al.   FASEB JOURNAL

Increased Muscle Force Production and Bone Mineral Density in ActRIIB-Fc-Treated Mature Rodents

(2013) C.-S. Chiu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Follistatin and activins in polycystic ovary syndrome: Relationship to metabolic and hormonal markers

(2013) Helena Teede et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum activin A does not predict ectopic pregnancy as a single measurement test, alone or as part of a multi-marker panel including progesterone and hCG

(2012) Joshua Warrick et al.   CLINICA CHIMICA ACTA

Regulation of activin A release from murine bone marrow-derived neutrophil precursors by tumour necrosis factor-α and insulin

(2012) Hui Wu et al.   CYTOKINE

Activin A StimulatesAKR1C3Expression and Growth in Human Prostate Cancer

(2012) Johannes Hofland et al.   ENDOCRINOLOGY

Activin Signaling Regulates Sertoli Cell Differentiation and Function

(2012) Peter K. Nicholls et al.   ENDOCRINOLOGY

Activin-βcreduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice

(2012) Elspeth Gold et al.   JOURNAL OF PATHOLOGY

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens

(2012) Wendy R. Winnall et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

Activins and activin antagonists in the prostate and prostate cancer

(2011) Elspeth Gold et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

New insights into the mechanisms of activin action and inhibition

(2011) Kelly L. Walton et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activin A Balances Sertoli and Germ Cell Proliferation in the Fetal Mouse Testis

(2010) S. H. S. Mendis et al.   BIOLOGY OF REPRODUCTION

Activin Bioactivity Affects Germ Cell Differentiation in the Postnatal Mouse Testis In Vivo1

(2010) Sridurga Mithraprabhu et al.   BIOLOGY OF REPRODUCTION

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

(2010) Sutada Lotinun et al.   BONE

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

(2010) Samuel M. Cadena et al.   JOURNAL OF APPLIED PHYSIOLOGY

Two Distinct Regions of Latency-associated Peptide Coordinate Stability of the Latent Transforming Growth Factor-β1 Complex

(2010) Kelly L. Walton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo

(2010) Andrew D Chantry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion

(2010) D. R. Archambeault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of the TGF-beta1 system in human testicular pathologies

(2010) Candela R Gonzalez et al.   Reproductive Biology and Endocrinology

Inhibin-betaC subunit expression in normal and pathological human placental tissues

(2010) Ioannis Mylonas et al.   Systems Biology in Reproductive Medicine

Upregulation of activin signaling in experimental colitis

(2009) You-Qing Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Common Biosynthetic Pathway Governs the Dimerization and Secretion of Inhibin and Related Transforming Growth Factor β (TGFβ) Ligands

(2009) Kelly L. Walton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Key Role for Activin B in Cellular Transformation after Loss of the von Hippel-Lindau Tumor Suppressor

(2009) I. Wacker et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia

(2009) E. Fitzpatrick et al.   MOLECULAR HUMAN REPRODUCTION

Maternal Circulating Levels of Activin A, Inhibin A, sFlt-1 and Endoglin at Parturition in Normal Pregnancy and Pre-Eclampsia

(2009) Aparna Reddy et al.   PLoS One

Analysis of activin/TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas

(2009) Vinali L Dias et al.   REPRODUCTION

A New Role for Activin in Endometrial Repair after Menses

(2008) Tu'uhevaha J. Kaitu'u-Lino et al.   ENDOCRINOLOGY

Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study)

(2008) Linda T Roten et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Endometrial Inhibin/Activin β-B Subunit Expression Is Related to Decidualization and Is Reduced in Tubal Ectopic Pregnancy

(2008) A. W. Horne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of TGF-β/Smad signaling on sertoli cell and possible mechanism related to complete sertoli cell-only syndrome

(2008) Tao Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice

(2008) Badia Barakat et al.   REPRODUCTION

Female Infertility and Disrupted Angiogenesis Are Actions of Specific Follistatin Isoforms

(2007) Shyr-Yeu Lin et al.   MOLECULAR ENDOCRINOLOGY