The Generation of Definitive Endoderm from Human Embryonic Stem Cells is Initially Independent from Activin A but Requires Canonical Wnt-Signaling

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Canonical Wnt Signaling Induces a Primitive Endoderm Metastable State in Mouse Embryonic Stem Cells

(2013) Feodor D. Price et al.   STEM CELLS

Efficient Derivation of Lateral Plate and Paraxial Mesoderm Subtypes from Human Embryonic Stem Cells Through GSKi-Mediated Differentiation

(2013) Jia Yong Tan et al.   STEM CELLS AND DEVELOPMENT

WNT3 Is a Biomarker Capable of Predicting the Definitive Endoderm Differentiation Potential of hESCs

(2013) Wei Jiang et al.   Stem Cell Reports

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

(2012) Wei Jiang et al.   CELL RESEARCH

Pluripotente Stammzellen zur Zellersatztherapie des Diabetes mellitus

(2012) O. Naujok et al.   DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

The Mix family of homeobox genes—Key regulators of mesendoderm formation during vertebrate development

(2012) Lloyd A. Pereira et al.   DEVELOPMENTAL BIOLOGY

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells

(2012) C. H.-H. Cho et al.   DIABETOLOGIA

Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells

(2012) Amanda L. Evans et al.   PLoS One

Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells

(2012) Leslie A. Kirby et al.   PLoS One

Wnt/ -catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

(2012) K. C. Davidson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors

(2012) Ortwin Naujok et al.   Stem Cell Reviews and Reports

Targeting SOX17 in Human Embryonic Stem Cells Creates Unique Strategies for Isolating and Analyzing Developing Endoderm

(2011) Pei Wang et al.   Cell Stem Cell

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

(2011) Andreia S. Bernardo et al.   Cell Stem Cell

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

(2011) H. K. Bone et al.   JOURNAL OF CELL SCIENCE

Insulin-producing Surrogate β-cells From Embryonic Stem Cells: Are We There Yet?

(2011) Ortwin Naujok et al.   MOLECULAR THERAPY

Brachyury and Related Tbx Proteins Interact with the Mixl1 Homeodomain Protein and Negatively Regulate Mixl1 Transcriptional Activity

(2011) Lloyd A. Pereira et al.   PLoS One

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells

(2011) Lloyd A. Pereira et al.   Stem Cell Research

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

(2011) Yuya Kunisada et al.   Stem Cell Research

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

(2010) Jacob H. Hanna et al.   CELL

Noggin, Retinoids, and Fibroblast Growth Factor Regulate Hepatic or Pancreatic Fate of Human Embryonic Stem Cells

(2010) Josué Kunjom Mfopou et al.   GASTROENTEROLOGY

A Small Molecule Primes Embryonic Stem Cells for Differentiation

(2009) Shoutian Zhu et al.   Cell Stem Cell

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/ -catenin, Activin/Nodal and BMP signaling

(2008) T. Sumi et al.   DEVELOPMENT

Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium

(2008) Mio Nakanishi et al.   FASEB JOURNAL

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Marked differences in differentiation propensity among human embryonic stem cell lines

(2008) Kenji Osafune et al.   NATURE BIOTECHNOLOGY

Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells

(2008) Zhi-Yong Zhang et al.   STEM CELLS