Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability

An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

(2015) Hamid Meziane et al.   BIOLOGICAL PSYCHIATRY

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

(2015) Karen A. Newell-Litwa et al.   JOURNAL OF CELL BIOLOGY

Reversal of novelty-induced hippocampal c-Fos expression in GluA1 subunit-deficient mice by chronic treatment targeting glutamatergic transmission

(2014) Milica Maksimovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

p140Cap Regulates Memory and Synaptic Plasticity through Src-Mediated and Citron-N-Mediated Actin Reorganization

(2014) D. Repetto et al.   JOURNAL OF NEUROSCIENCE

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

Intellectual disability and autism spectrum disorders: Causal genes and molecular mechanisms

(2014) Anand K. Srivastava et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Reduced Gamma Oscillations in a Mouse Model of Intellectual Disability: A Role for Impaired Repetitive Neurotransmission?

(2014) Andrew D. Powell et al.   PLoS One

Behavioural alterations relevant to developmental brain disorders in mice with neonatally induced ventral hippocampal lesions

(2013) Arne Naert et al.   BRAIN RESEARCH BULLETIN

Rho GTPase signaling at the synapse: Implications for intellectual disability

(2013) Wei Ba et al.   EXPERIMENTAL CELL RESEARCH

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway

(2013) M. Khelfaoui et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat

(2012) Laura Butruille et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis

(2012) J. Walsh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The trouble with spines in fragile X syndrome: density, maturity and plasticity

(2012) C.X. He et al.   NEUROSCIENCE

Pathological Plasticity in Fragile X Syndrome

(2012) Brandon S. Martin et al.   NEURAL PLASTICITY

Genetic and Epigenetic Networks in Intellectual Disabilities

(2011) Hans van Bokhoven   Annual Review of Genetics

Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels

(2011) Saadettin Sel et al.   GENE EXPRESSION PATTERNS

Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation

(2011) Andrew D. Powell et al.   JOURNAL OF PHYSIOLOGY-LONDON

Emerging major synaptic signaling pathways involved in intellectual disability

(2011) A Pavlowsky et al.   MOLECULAR PSYCHIATRY

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα

(2011) Pamela Valnegri et al.   NATURE NEUROSCIENCE

Rapid Synthesis of the X-Linked Mental Retardation Protein OPHN1 Mediates mGluR-Dependent LTD through Interaction with the Endocytic Machinery

(2011) Nael Nadif Kasri et al.   NEURON

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride

(2011) Y. Hou et al.   NEUROSCIENCE

Signaling mechanisms regulating synapse formation and function in mental retardation

(2010) Bernadett Boda et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

RhoA Phosphorylation Induces Rac1 Release from Guanine Dissociation Inhibitor   and Stimulation of Vascular Smooth Muscle Cell Migration

(2010) M. Rolli-Derkinderen et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rho-Linked Mental Retardation Protein OPHN1 Controls Synaptic Vesicle Endocytosis via Endophilin A1

(2009) Akiko Nakano-Kobayashi et al.   CURRENT BIOLOGY

The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors

(2009) N. Nadif Kasri et al.   GENES & DEVELOPMENT

Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation

(2009) Malik Khelfaoui et al.   HUMAN MOLECULAR GENETICS

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Reversing Neurodevelopmental Disorders in Adults

(2008) Dan Ehninger et al.   NEURON