Article
Multidisciplinary Sciences
Alastair G. Kerr, Zuoneng Wang, Na Wang, Kelvin H. M. Kwok, Jutta Jalkanen, Alison Ludzki, Simon Lecoutre, Dominique Langin, Martin O. Bergo, Ingrid Dahlman, Carsten Mim, Peter Arner, Hui Gao
Summary: The study identifies ADIPINT, a human adipocyte-specific lncRNA, as a regulator of lipid metabolism in white adipocytes. ADIPINT interacts with pyruvate carboxylase and affects its abundance and enzymatic activity, which in turn influences adipocyte lipid synthesis and breakdown. ADIPINT expression is increased in obesity and is associated with adipose insulin resistance and pyruvate carboxylase activity.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Irving L. M. H. Aye, Fredrick J. Rosario, Anita Kramer, Oddrun Kristiansen, Trond M. Michelsen, Theresa L. Powell, Thomas Jansson
Summary: Obesity in pregnancy is associated with adipose tissue inflammation, endoplasmic reticulum stress, insulin resistance, increased adiponectin ubiquitination, and decreased total abundance of adiponectin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Benjamin Schroeder, Sabine Kahl, Michael Roden
Summary: Individuals with obesity or type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease, with altered adipose tissue function and hepatic mitochondrial dysfunction playing key roles in the pathogenesis. Genetic testing for high-risk individuals, particularly for the rs738409(G) SNP of the PNPLA3 gene, could improve future screening strategies.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Immunology
Mandana Khalili, Wendy C. King, David E. Kleiner, Mamta K. Jain, Raymond T. Chung, Mark Sulkowski, Mauricio Lisker-Melman, David K. Wong, Marc Ghany, Arun Sanyal, Richard K. Sterling
Summary: The study found that about 30% of HIV-HBV coinfected individuals had FLD, with 10% having steatohepatitis. FLD was associated with non-black race, metabolic risks, an atherogenic lipid profile, and elevated ALT over time. Identifying FLD and managing adverse metabolic profiles is crucial in HIV-HBV coinfection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Agriculture, Dairy & Animal Science
Miguel Chirivi, C. Javier Rendon, Madison N. Myers, Crystal M. Prom, Sambit Roy, Aritro Sen, Adam L. Lock, G. Andres Contreras
Summary: The exposure to endotoxin can enhance lipolysis and reduce insulin sensitivity in adipose tissue, leading to decreased sensitivity of adipocytes to the antilipolytic action of insulin.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Medicine, Research & Experimental
Samar H. Gerges, Sara A. Wahdan, Doaa A. Elsherbiny, Ebtehal El-Demerdash
Summary: NAFLD is a disorder characterized by excessive fat accumulation in the liver, which can progress to NASH, accompanied by inflammation and fibrosis. The pathophysiology of NAFLD and NASH involves a complex interplay between metabolic, environmental, and genetic factors. Currently, there is no FDA-approved treatment for NAFLD and NASH, with off-label medications and hepatoprotective agents being used instead.
Article
Biochemistry & Molecular Biology
Adam Prabata, Koji Ikeda, Elda Putri Rahardini, Ken-Ichi Hirata, Noriaki Emoto
Summary: The study demonstrates that GPNMB negatively regulates macrophage inflammatory capacities and ameliorates WAT inflammation in obesity, making it a promising therapeutic target for metabolic disorders associated with obesity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Article
Biology
Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Summary: The study examines the role of adipocyte hormone-sensitive lipase (HSL) in regulating whole body energy homeostasis, showing that adipocyte-specific HSL knockout (AHKO) mice fed a high-fat diet develop fatty liver but may reverse with age. The reversal is possibly linked to diminished lipolytic activity in adipose tissue and pronounced lipodystrophy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michelle Berenice Vega Joubert, Paola Ingaramo, Maria Eugenia Oliva, Maria Eugenia D'Alessandro
Summary: The study revealed that chronic consumption of a sucrose-rich diet can lead to dyslipidemia, hyperglycemia, hepatic lipid accumulation, and liver injury in rats. However, incorporating chia seed into the diet for 3 months showed beneficial effects in reversing these issues and improving liver health by reducing oxidative stress.
Article
Biochemistry & Molecular Biology
Klaudia Berk, Karolina Konstantynowicz-Nowicka, Tomasz Charytoniuk, Ewa Harasim-Symbor, Adrian Chabowski
Summary: Available data suggests that cannabidiol (CBD) can improve symptoms of insulin resistance by modulating sphingolipid concentrations. CBD reduces ceramide content in adipose tissues, enhancing insulin sensitivity. Therefore, CBD may be considered as a potential therapeutic strategy for treating insulin resistance and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huqun Li, Chongshu Wang, Jiefang Zhao, Cuilian Guo
Summary: JNK plays a role in olanzapine-induced insulin resistance by promoting IRS1Ser307 phosphorylation and inflammation in eWAT, indicating its potential as a drug target for this condition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell & Tissue Engineering
Valeria C. O. Povoa, Giovanna J. V. P. dos Santos, Guilherme F. Picheth, Carlos P. Jara, Laura C. E. da Silva, Eliana P. de Araujo, Marcelo G. de Oliveira
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Medicine, Research & Experimental
Eli Mansour, Flavia F. Bueno, Jose C. de Lima-Junior, Andre Palma, Milena Monfort-Pires, Bruna Bombassaro, Eliana P. Araujo, Ana Flavia Bernardes, Raisa G. Ulaf, Thyago A. Nunes, Luciana C. Ribeiro, Antonio Luis E. Falcao, Thiago Martins Santos, Plinio Trabasso, Rachel P. Dertkigil, Sergio S. Dertkigil, Rafael P. Maia, Tatiana Benaglia, Maria Luiza Moretti, Licio A. Velloso
Summary: This study aims to explore the mechanism of increased bradykinin in the lungs of COVID-19 patients in developing pneumonia and respiratory failure, with three arms of randomized clinical trial designed for different treatment regimens. The results of the study may help alleviate lung inflammatory response in severe COVID-19 patients, positively impacting disease severity and mortality rates.
Review
Allergy
Natalia F. Mendes, Carlos P. Jara, Eli Mansour, Eliana P. Araujo, Licio A. Velloso
Summary: A systematic review of all reports on COVID-19 published between December 2019 and June 30, 2020 found conflicting results regarding the potential association between asthma and severe COVID-19. Only 1.6% of patients diagnosed with COVID-19 were reported to have asthma as a premorbid condition, suggesting that asthma may not be a significant contributing factor to the development of COVID-19.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Natalia Ferreira Mendes, Carlos Poblete Jara, Ariane Maria Zanesco, Eliana Pereira de Araujo
Summary: Under high-fat feeding, the hypothalamus undergoes pro-inflammatory signaling activation, with recent data revealing microglial heterogeneity throughout the brain. The roles of microglial subpopulations in hypothalamic inflammation have been studied, but how each subset functions in response to inflammatory stimuli remains unclear. Novel experimental models have been developed to study the characteristics and roles of microglial subtypes, and transcriptomic data is being used to identify changes in hypothalamic microglial signature under short-term and long-term high-fat feeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Vanessa C. Bobbo, Daiane F. Engel, Carlos Poblete Jara, Natalia F. Mendes, Roberta Haddad-Tovolli, Thais P. Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A. Velloso, Eliana P. Araujo
Summary: IL6 in the hypothalamus induces neurogenesis-related gene expression in both wild-type and IL6 knockout mice, potentially offering a approach to prevent or attenuate obesity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Carlos Poblete Jara, Beatriz de Andrade Berti, Natalia Ferreira Mendes, Daiane Fatima Engel, Ariane Maria Zanesco, Gabriela Freitas Pereira de Souza, Renan de Medeiros Bezerra, Julia de Toledo Bagatin, Silvya Stuchi Maria-Engler, Joseane Morari, William H. Velander, Licio A. Velloso, Eliana Pereira Araujo
Summary: The study demonstrates that exogenous glutamic acid can promote hair growth and keratinocyte proliferation, while reducing apoptosis-related gene expression and increasing cell viability and proliferation. These findings suggest a potential novel skin signalling pathway mediated by neurotransmitters in controlling skin cell growth, offering new possibilities for using glutamic acid in the treatment of skin diseases.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Carlos Poblete Jara, Rodrigo S. Carraro, Ariane Zanesco, Beatriz Andrade, Karina Moreira, Guilherme Nogueira, Bruno L. Souza, Thais Paulino Prado, Valeria Povoa, William Velander, Licio A. Velloso, Eliana P. Araujo
Summary: By comparing two different approaches for anesthesia dosage calculation, this study found that the use of a mobile app significantly reduces anesthesia-related deaths, offering a potential solution to a longstanding challenge faced by researchers working with experimental mice.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Neurosciences
Rodrigo S. Carraro, Guilherme A. Nogueira, Davi Sidarta-Oliveira, Rodrigo S. Gaspar, Nathalia R. Dragano, Joseane Morari, Vanessa C. D. Bobbo, Eliana P. Araujo, Natalia F. Mendes, Ariane M. Zanesco, Natalia Tobar, Celso D. Ramos, Jessica M. Toscaro, Marcio C. Bajgelman, Licio A. Velloso
Summary: NHLH2 is a hypothalamic transcription factor that plays a role in energy homeostasis and obesity. Overexpression of NHLH2 in mice can prevent and reduce obesity by affecting caloric intake.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Karina Gomes Moreira, Thais Paulino do Prado, Natalia Ferreira Mendes, Renan de Medeiros Bezerra, Carlos Poblete Jara, Maria Helena Melo Lima, Eliana Pereira de Araujo
Summary: Piperonylic acid can promote cell growth, proliferation, and survival in skin tissues, improve wound healing through EGFR activation, and modulate gene expression important for the healing process. Topical application of piperonylic acid accelerates wound healing from day 6 post-injury and results in new tissue with increased type I collagen deposition and morphology closer to intact skin.
Article
Multidisciplinary Sciences
Li Han, Carlos P. Jara, Ou Wang, Yu Shi, Xinran Wu, Sandra Thibivilliers, Rafal K. Woycicki, Mark A. Carlson, William H. Velander, Eliana P. Araujo, Marc Libault, Chi Zhang, Yuguo Lei
Summary: This study presents a robust method for isolating and cryopreserving pig skin single cells for scRNA-seq, allowing researchers to identify major skin cell types in pigs.
Article
Cardiac & Cardiovascular Systems
Rafael L. Camargo, Bruna Bombassaro, Milena Monfort-Pires, Eli Mansour, Andre C. Palma, Luciana C. Ribeiro, Raisa G. Ulaf, Ana Flavia Bernardes, Thyago A. Nunes, Marcus V. Agrela, Rachel P. Dertkigil, Sergio S. Dertkigil, Eliana P. Araujo, Wilson Nadruz, Maria Luiza Moretti, Licio A. Velloso, Andrei C. Sposito
Summary: This study investigated the blood levels of ACE, ACE2, angiotensin-II, angiotensin (1-7), and angiotensin (1-9) in patients with COVID-19 and found that elevated levels of angiotensin-II were associated with a higher risk of developing critical symptoms. Early measurement of angiotensin-II could serve as a useful biomarker for identifying patients at higher risk of severe progression of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Robert Haddad Tovolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bobbo, Rodrigo S. Carraro, Carina Solon, Nathalia R. Dragano, Marcio A. Torsoni, Eliana P. Araujo, Licio A. Velloso
Summary: Maternal obesity is a significant risk factor for obesity, cardiovascular, and metabolic diseases in offspring. It leads to inflammation in the hypothalamus of the offspring, affecting the function of neurons that regulate food intake and energy expenditure. Maternal obesity-induced structural and functional damage to the offspring's hypothalamic BBB, but breastfeeding by lean mothers can partially reverse these effects.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nursing
Thais P. Prado, Carlos P. Jara, Vanessa C. Dias Bobbo, Rodrigo S. Carraro, Davi Sidarta-Oliveira, Guilherme R. A. de Mendonca, Licio A. Velloso, Eliana P. Araujo
Summary: The aim of this study was to evaluate the effects of topical GW9508 on wound healing in mice. The results showed that GW9508 accelerated wound healing, decreased the expression of IL-10 and metalloproteinase 9 genes, increased the quantity of Collagen I, and improved the organization of collagen fibres. Therefore, GW9508 could be an attractive drug treatment for wounded skin.
BIOLOGICAL RESEARCH FOR NURSING
(2023)
Article
Biology
T. P. Prado, J. Morari, E. P. Araujo
Summary: Diabetes increases the risk of skin infections and foot ulcers. The effects of diabetes on uninjured skin are less studied. However, it is known that diabetes can cause increased oxidative stress and lipid peroxidation. In this study, hyperglycemia in mice induced a decrease in Il-6 and an increase in Tnf-a, Il-10, F4/80, Tgf-b, and Igf-1. It also led to lower cellular density, delayed collagen fiber maturation, decreased neuron number, and decreased Bdnf expression in the skin.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Virology
Bruna Rafaela Santos Silva, Carlos Poblete Jara, Davi Sidarta-Oliveira, Licio A. Velloso, William H. Velander, Eliana P. Araujo
Summary: This study found changes in the expression of the protein C signaling network in patients with COVID-19, including downregulation of protein C and its downstream cascade components. Transcripts encoding proteins at the interface between coagulation and the immune system were upregulated in the liver and peripheral blood cells, while ciliated cells in the nasal epithelium expressed transcripts encoding both ACE2 and proteins related to the coagulation and immune system interface.