Influence of prenatal EGCG treatment andDyrk1adosage reduction on craniofacial features associated with Down syndrome

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

(2016) Fiorenza Stagni et al.   NEUROSCIENCE

Chronic up-regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice

(2015) Nandini Singh et al.   DEVELOPMENTAL DYNAMICS

Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomicDyrk1a

(2015) Joshua D. Blazek et al.   HUMAN MOLECULAR GENETICS

Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice

(2015) Tara Dutka et al.   MECHANISMS OF DEVELOPMENT

Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner

(2015) Joshua D. Blazek et al.   MECHANISMS OF DEVELOPMENT

Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model

(2015) Megan Stringer et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Timing of therapies for Down syndrome: the sooner, the better

(2015) Fiorenza Stagni et al.   Frontiers in Behavioral Neuroscience

Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice

(2014) John M. Starbuck et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies

(2014) Walter Becker et al.   CNS & Neurological Disorders-Drug Targets

Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology

(2014) N. Singh et al.   Disease Models & Mechanisms

Hand in glove: brain and skull in development and dysmorphogenesis

(2013) Joan T. Richtsmeier et al.   ACTA NEUROPATHOLOGICA

Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome

(2013) Cherie N. Billingsley et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Trisomy 21 and facial developmental instability

(2013) John M. Starbuck et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Commonality in Down and fetal alcohol syndromes

(2013) Jeffrey P. Solzak et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Noninvasive prenatal testing creates an opportunity for antenatal treatment of Down syndrome

(2013) Faycal Guedj et al.   PRENATAL DIAGNOSIS

The neural crest in vertebrate evolution

(2012) Nicole M Le Douarin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis

(2012) Yanyan Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Morphological integration of soft-tissue facial morphology in down syndrome and siblings

(2011) John Starbuck et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

(2011) B. Hammerle et al.   DEVELOPMENT

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

The Preventive Effect of Oral EGCG in a Fetal Alcohol Spectrum Disorder Mouse Model

(2010) Ling Long et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

(2010) Tatyana Adayev et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice

(2010) Joshua D. Blazek et al.   BONE

Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome

(2010) Joshua D. Blazek et al.   DEVELOPMENTAL DYNAMICS

Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

(2010) O. Yabut et al.   JOURNAL OF NEUROSCIENCE

Complex contributions ofEts2to craniofacial and thymus phenotypes of trisomic “Down syndrome” mice

(2009) Cheryl A. Hill et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

(2009) Youngkyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Masticatory dysfunction in persons with Down’s syndrome. Part 1: aetiology and incidence

(2008) D. FAULKS et al.   JOURNAL OF ORAL REHABILITATION

A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog

(2008) Randall J. Roper et al.   MECHANISMS OF DEVELOPMENT