Dmpkgene deletion or antisense knockdown does not compromise cardiac or skeletal muscle function in mice

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

(2015) Kim A. Lennox et al.   NUCLEIC ACIDS RESEARCH

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA

(2015) Timothy A. Vickers et al.   NUCLEIC ACIDS RESEARCH

An RNA biosensor for imaging the first round of translation from single cells to living animals

(2015) J. M. Halstead et al.   SCIENCE

Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

(2014) Ranjan Batra et al.   MOLECULAR CELL

Myotonic Dystrophy

(2014) Charles A. Thornton   NEUROLOGIC CLINICS

Isolation and Physiological Analysis of Mouse Cardiomyocytes

(2014) Gretchen M. Roth et al.   Jove-Journal of Visualized Experiments

Reducing Levels of Toxic RNA with Small Molecules

(2013) Leslie A. Coonrod et al.   ACS Chemical Biology

Splicing biomarkers of disease severity in myotonic dystrophy

(2013) Masayuki Nakamori et al.   ANNALS OF NEUROLOGY

Compound loss of muscleblind-like function in myotonic dystrophy

(2013) Kuang-Yung Lee et al.   EMBO Molecular Medicine

Altered Cardiac Electrophysiology and SUDEP in a Model of Dravet Syndrome

(2013) David S. Auerbach et al.   PLoS One

Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins

(2012) Eric T. Wang et al.   CELL

Electrophysiological Study With Prophylactic Pacing and Survival in Adults With Myotonic Dystrophy and Conduction System Disease

(2012) Karim Wahbi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting nuclear RNA for in vivo correction of myotonic dystrophy

(2012) Thurman M. Wheeler et al.   NATURE

Structure–Function Relationship in the Sinus and Atrioventricular Nodes

(2012) T. Nikolaidou et al.   PEDIATRIC CARDIOLOGY

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA

(2012) Peter Järver et al.   Molecular Therapy-Nucleic Acids

Variable phenotype in murine transverse aortic constriction

(2011) Selma F. Mohammed et al.   CARDIOVASCULAR PATHOLOGY

Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

(2011) Jeffrey B Carroll et al.   MOLECULAR THERAPY

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice

(2011) Nikola Cesarovic et al.   Jove-Journal of Visualized Experiments

Increased mortality with left ventricular systolic dysfunction and heart failure in adults with myotonic dystrophy type 1

(2010) Deepak Bhakta et al.   AMERICAN HEART JOURNAL

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues

(2010) Arturo López Castel et al.   HUMAN MOLECULAR GENETICS

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

(2010) Frederick J Raal et al.   LANCET

An Upstream Open Reading Frame and the Context of the Two AUG Codons Affect the Abundance of Mitochondrial and Nuclear RNase H1

(2010) Y. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Preclinical PK and PD Studies on 2′-O-Methyl-phosphorothioate RNA Antisense Oligonucleotides in the mdx Mouse Model

(2010) Hans Heemskerk et al.   MOLECULAR THERAPY

Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs

(2010) Virginie François et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Non-ATG-initiated translation directed by microsatellite expansions

(2010) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transverse Aortic Constriction in Mice

(2010) Angela C. deAlmeida et al.   Jove-Journal of Visualized Experiments

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

(2008) Punit P. Seth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Electrocardiographic Abnormalities and Sudden Death in Myotonic Dystrophy Type 1

(2008) William J. Groh et al.   NEW ENGLAND JOURNAL OF MEDICINE