Essential nontranslational functions of tRNA synthetases

Concomitant Tumor Resistance: The Role of Tyrosine Isomers in the Mechanisms of Metastases Control

(2012) R. A. Ruggiero et al.   CANCER RESEARCH

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Coding Region Polyadenylation Generates a Truncated tRNA Synthetase that Counters Translation Repression

(2012) Peng Yao et al.   CELL

Yeast Mitochondrial Leucyl-tRNA Synthetase CP1 Domain Has Functionally Diverged to Accommodate RNA Splicing at Expense of Hydrolytic Editing

(2012) Jaya Sarkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIMP3/p18 Controls Translational Initiation by Mediating the Delivery of Charged Initiator tRNA to Initiation Complex

(2012) Taehee Kang et al.   JOURNAL OF MOLECULAR BIOLOGY

Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1

(2012) Nava Segev et al.   MOLECULAR CELL

Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription

(2012) Yifat Ofir-Birin et al.   MOLECULAR CELL

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

(2012) Mathew Sajish et al.   Nature Chemical Biology

Alanyl-tRNA synthetase mutation in a family with dominant distal hereditary motor neuropathy

(2012) Z. Zhao et al.   NEUROLOGY

Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis

(2012) M. C. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing

(2012) Zhiwen Xu et al.   STRUCTURE

Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer

(2012) Jin Woo Choi et al.   Journal of Molecular Cell Biology

Unique domain appended to vertebrate tRNA synthetase is essential for vascular development

(2012) Xiaoling Xu et al.   Nature Communications

Amino Acid Signaling in TOR Activation

(2011) Joungmok Kim et al.   Annual Review of Biochemistry

Dominant Intermediate Charcot-Marie-Tooth Disorder Is Not Due to a Catalytic Defect in Tyrosyl-tRNA Synthetase

(2011) Clifford A. Froelich et al.   BIOCHEMISTRY

Tumor-seeking Salmonella amino acid auxotrophs

(2011) Robert M Hoffman   CURRENT OPINION IN BIOTECHNOLOGY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Hypoxia Signature of Splice Forms of Tryptophanyl-tRNA Synthetase Marks Pancreatic Cancer Cells With Distinct Metastatic Abilities

(2011) Elena L. Paley et al.   PANCREAS

Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening

(2011) W. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control

(2011) A. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3

(2011) N. H. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis

(2011) Jin Woo Choi et al.   PLoS Genetics

Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus

(2010) Sang Gyu Park et al.   BIOMARKERS

Antitumor effects of EMAP II against pancreatic cancer through inhibition of fibronectin-dependent proliferation

(2010) Roderich E. Schwarz et al.   CANCER BIOLOGY & THERAPY

Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies

(2010) Neil Justin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A proteomic approach based on multiple parallel separation for the unambiguous identification of an antibody cognate antigen

(2010) Joohee Mun et al.   ELECTROPHORESIS

Chlorinated Benzenes Cause Concomitantly Oxidative Stress and Induction of Apoptotic Markers in Lung Epithelial Cells (A549) at Nonacute Toxic Concentrations

(2010) Nora Mörbt et al.   JOURNAL OF PROTEOME RESEARCH

An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations

(2010) Morgane Stum et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Evolution of Function of a Fused Metazoan tRNA Synthetase

(2010) P. S. Ray et al.   MOLECULAR BIOLOGY AND EVOLUTION

New functions of aminoacyl-tRNA synthetases beyond translation

(2010) Min Guo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice

(2010) Jung Min Han et al.   PLoS One

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

The Prognostic Significance of Tryptophanyl-tRNA Synthetase in Colorectal Cancer

(2009) A. Ghanipour et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis

(2009) J. W. Choi et al.   CARCINOGENESIS

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

Genetic Evidence for a Noncanonical Function of Seryl-tRNA Synthetase in Vascular Development

(2009) Wiebke Herzog et al.   CIRCULATION RESEARCH

Noncanonical Activity of Seryl-tRNA Synthetase Is Involved in Vascular Development

(2009) Hajime Fukui et al.   CIRCULATION RESEARCH

AIMP2 promotes TNF -dependent apoptosis via ubiquitin-mediated degradation of TRAF2

(2009) J. W. Choi et al.   JOURNAL OF CELL SCIENCE

P43/pro-EMAPII: A Potential Biomarker for Discriminating Traumatic Versus Ischemic Brain Injury

(2009) Changping Yao et al.   JOURNAL OF NEUROTRAUMA

LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression

(2009) Nurit Yannay-Cohen et al.   MOLECULAR CELL

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality

(2009) Quansheng Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

MSC p43 required for axonal development in motor neurons

(2009) X. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

(2009) Jian Wang et al.   SCIENCE

The GAIT system: a gatekeeper of inflammatory gene expression

(2009) Rupak Mukhopadhyay et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Aminoacyl-tRNA Synthetases in Genetic Diseases

(2008) Anthony Antonellis et al.   Annual Review of Genomics and Human Genetics

Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity

(2008) Ran He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Determination of Three-dimensional Structure and Residues of the Novel Tumor Suppressor AIMP3/p18 Required for the Interaction with ATM

(2008) Kyung-Jin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Important Role for the Multienzyme Aminoacyl-tRNA Synthetase Complex in Mammalian Translation and Cell Growth

(2008) Sophia V. Kyriacou et al.   MOLECULAR CELL

WHEP Domains Direct Noncanonical Function of Glutamyl-Prolyl tRNA Synthetase in Translational Control of Gene Expression

(2008) Jie Jia et al.   MOLECULAR CELL

Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA

(2008) Paul J. Paukstelis et al.   NATURE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53

(2008) J. M. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA