The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells

The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response

(2014) Teodora Nikolova et al.   TOXICOLOGICAL SCIENCES

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells

(2013) Nami Yamada et al.   CANCER LETTERS

Contribution of ATM and ATR to the Resistance of Glioblastoma and Malignant Melanoma Cells to the Methylating Anticancer Drug Temozolomide

(2013) Marcus Eich et al.   MOLECULAR CANCER THERAPEUTICS

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Anthracyclines, HER2, and TOP2A: the verdict

(2011) Hervé R Bonnefoi   LANCET ONCOLOGY

Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells

(2011) N. Berdelle et al.   MOLECULAR CANCER THERAPEUTICS

Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

(2010) Christina Hackl et al.   BMC CANCER

Should anthracyclines and dexrazoxane be used for children with cancer?

(2010) Elvira C van Dalen et al.   LANCET ONCOLOGY

Opposing roles for calcineurin and ATF3 in squamous skin cancer

(2010) Xunwei Wu et al.   NATURE

Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways

(2010) S-H Lee et al.   ONCOGENE

53BP1: function and mechanisms of focal recruitment

(2009) Jennifer E. FitzGerald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells

(2009) R P Sahu et al.   BRITISH JOURNAL OF CANCER

ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress

(2009) L Turchi et al.   CELL DEATH AND DIFFERENTIATION

Topoisomerase II -dependent and -independent apoptotic effects of dexrazoxane and doxorubicin

(2009) T. Yan et al.   MOLECULAR CANCER THERAPEUTICS

Down-regulation of Inhibition of Differentiation-1 via Activation of Activating Transcription Factor 3 and Smad Regulates REIC/Dickkopf-3-Induced Apoptosis

(2008) Y. Kashiwakura et al.   CANCER RESEARCH

Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway

(2008) L Turchi et al.   CELL DEATH AND DIFFERENTIATION

KLF6 Induces Apoptosis in Prostate Cancer Cells through Up-regulation of ATF3

(2008) Xiangwei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

(2008) Darren J. Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy

(2008) Elke Martin et al.   TOXICOLOGY