Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Feng Luan, Lei Wang, Xue-Feng Gai
Summary: CAMTA2 is highly expressed in colon cancer and correlated with poor survival. miR-28-5p regulates CAMTA2 expression in colon cancer. The miR-28-5p/CAMTA2 axis plays a critical role in human colon cancer development and may be a potential target for diagnosis and treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Oncology
Markus A. Brown, Thomas Ried
Summary: The major signaling pathways in colon cancer are WNT, RAS, and TGF-beta. Mutations in these pathways reflect the behavior of intestinal stem cells and play a role in the progression of colon cancer. Understanding the intersection and interaction between these pathways can provide insights into the regulation of cell proliferation and the development of colon cancer.
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yanjin Fu, Haiquan Liu, Mengsha Long, Linliang Song, Zuyu Meng, Shaozi Lin, Yiyao Zhang, JiaJia Qin
Summary: This study demonstrated for the first time that icariin significantly attenuated the growth of ovarian tumors and revealed that it suppresses tumor progression by upregulating miR-1-3p to inhibit TNKS2/Wnt/β-catenin signaling in ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.
Article
Oncology
Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia, Hong Zhang
Summary: MiR-200c overexpression inhibits the proliferation of colon cancer cells by downregulating FUT4 and consequently suppressing the Wnt/β-catenin signaling pathway. In vivo experiments further confirmed the findings from the cell studies.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Food Science & Technology
Jiawei He, Anhui Yang, Xuyu Zhao, Yang Liu, Shuyan Liu, Di Wang
Summary: Gloeostereum incarnatum polysaccharides (GIPS) exhibit anti-colon cancer effects by regulating cytokines and the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory and tumor growth inhibition properties.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu, Yan Lu
Summary: This study identifies circFBXO7, a novel circRNA, as a tumor suppressor in ovarian cancer. The circFBXO7/miR-96-5p/MTSS1 axis is found to be an important regulator in the Wnt/beta-catenin signaling pathway.
Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Article
Oncology
Yihan Wang, Yi Cao
Summary: This study revealed that miR-145-5p was downregulated in patients with psoriasis, but upregulating miR-145-5p can activate the Wnt beta-catenin signaling pathway, thereby inhibiting the progression of psoriasis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kohei Taniguchi, Nobuhiko Sugito, Minami Kumazaki, Haruka Shinohara, Nami Yamada, Nobuhisa Matsuhashi, Manabu Futamura, Yuko Ito, Yoshinori Otsuki, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Article
Oncology
Haruka Shinohara, Kohei Taniguchi, Minami Kumazaki, Nami Yamada, Yuko Ito, Yoshinori Otsuki, Bunji Uno, Fumihiko Hayakawa, Yosuke Minami, Tomoki Naoe, Yukihiro Akao
Article
Oncology
Haruka Shinohara, Minami Kumazaki, Yosuke Minami, Yuko Ito, Nobuhiko Sugito, Yuki Kuranaga, Kohei Taniguchi, Nami Yamada, Yoshinori Otsuki, Tomoki Naoe, Yukihiro Akao
Article
Oncology
Nami Yamada, Yuki Kuranaga, Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Yukihiro Akao
Article
Oncology
Kohei Taniguchi, Miku Sakai, Nobuhiko Sugito, Minami Kumazaki, Haruka Shinohara, Nami Yamada, Tatsushi Nakayama, Hiroshi Ueda, Yoshihito Nakagawa, Yuko Ito, Manabu Futamura, Bunji Uno, Yoshinori Otsuki, Kazuhiro Yoshida, Kazuhisa Uchiyama, Yukihiro Akao
Editorial Material
Oncology
Nami O. Yamada
TRANSLATIONAL CANCER RESEARCH
(2016)
Article
Biology
Tuya Wang, Takanori Onouchi, Nami O. Yamada, Shuji Matsuda, Takao Senda
MEDICAL MOLECULAR MORPHOLOGY
(2017)
Article
Biology
Nami O. Yamada, Wenduerma, Shuji Matsuda, Takao Senda
MEDICAL MOLECULAR MORPHOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Nami O. Yamada, Kazuki Heishima, Yukihiro Akao, Takao Senda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biology
Chenguang Li, Takanori Onouchi, Masaya Hirayama, Kazuyoshi Sakai, Shuji Matsuda, Nami O. Yamada, Takao Senda
Summary: In this study, abnormal morphology of the hippocampus in APC(1638T/1638T) mice was found, and the failure of APC1638T to bind to AMPA-R and PSD-95 may result in reduced activity of hippocampal neurons in APC(1638T/1638T) mice.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Biology
Wenduerma, Nami O. Yamada, Tuya Wang, Takao Senda
Summary: The study reveals abnormalities in the proliferation and differentiation of intestinal stem cell lineages, as well as delayed shedding of apoptotic cells at the villus tips in APC1638T mice. These disruptions may contribute to the elongation of villi in the jejunum of APC1638T mice.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Review
Biology
Nami O. Yamada, Takao Senda
Summary: Recent studies have found that miRNAs are present in body fluids in a stable form, called circulating miRNAs, and are considered as mediators of intercellular communication like hormones and cytokines. Circulating miRNAs can be collected in a non-invasive manner and have been studied as potential biomarkers for various diseases, including cancers.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Correction
Biology
Nami O. Yamada, Takao Senda
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Biology
Nami O. Yamada, Wenduerma, Takao Senda
Summary: In this study, we found that APC1638T mice exhibited large intestinal dysmotility and alterations in gut microbiota composition. We also observed over-activation of gut immune tissue. These findings contribute to our understanding of APC's functions in gastrointestinal motility and provide a basis for the development of novel therapies for gut dysmotility-related diseases.
MEDICAL MOLECULAR MORPHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuki Kuranaga, Nami Yamada, Maiko Kashiwaya, Moeko Nakamura, Lei Cui, Minami Kumazaki, Haruka Shinohara, Nobuhiko Sugito, Kohei Taniguchi, Yuko Ito, Tatsushi Nakayama, Bunji Uno, Akichika Itoh, Yukihiro Akao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.