Deep tissue imaging: a review from a preclinical cancer research perspective

Chemical Principles in Tissue Clearing and Staining Protocols for Whole-Body Cell Profiling

(2016) Kazuki Tainaka et al.   Annual Review of Cell and Developmental Biology

Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts

(2016) Hana Kolesová et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Tumor Uptake of Anti-CD20 Fabs Depends on Tumor Perfusion

(2016) C. T. Mendler et al.   JOURNAL OF NUCLEAR MEDICINE

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent

(2016) Meng-Tsen Ke et al.   Cell Reports

Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

(2016) Michael O Breckwoldt et al.   eLife

ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging

(2016) Eunsoo Lee et al.   Scientific Reports

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

(2015) Evan Murray et al.   CELL

Clarifying Tissue Clearing

(2015) Douglas S. Richardson et al.   CELL

Light sheet-based fluorescence microscopy (LSFM) for the quantitative imaging of cells and tissues

(2015) Francesco Pampaloni et al.   CELL AND TISSUE RESEARCH

Optical properties of mouse brain tissue after optical clearing with FocusClear™

(2015) Austin J. Moy et al.   JOURNAL OF BIOMEDICAL OPTICS

Application of GFP imaging in cancer

(2015) Robert M Hoffman   LABORATORY INVESTIGATION

ScaleS: an optical clearing palette for biological imaging

(2015) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping

(2015) Jennifer B Treweek et al.   Nature Protocols

Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging

(2015) Etsuo A Susaki et al.   Nature Protocols

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

A versatile clearing agent for multi-modal brain imaging

(2015) Irene Costantini et al.   Scientific Reports

Fluorescent-Protein Stabilization and High-Resolution Imaging of Cleared, Intact Mouse Brains

(2015) Martin K. Schwarz et al.   PLoS One

Multispectral Fluorescence Ultramicroscopy: Three-Dimensional Visualization and Automatic Quantification of Tumor Morphology, Drug Penetration, and Antiangiogenic Treatment Response

(2015) Michael Dobosz et al.   NEOPLASIA

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Whole-Body Imaging with Single-Cell Resolution by Tissue Decolorization

(2014) Kazuki Tainaka et al.   CELL

Use of labeled tomato lectin for imaging vasculature structures

(2014) Richard T. Robertson et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Dynamic Contrast-Enhanced Micro–Computed Tomography Correlates With 3-Dimensional Fluorescence Ultramicroscopy in Antiangiogenic Therapy of Breast Cancer Xenografts

(2014) Thomas Pöschinger et al.   INVESTIGATIVE RADIOLOGY

Advanced CLARITY for rapid and high-resolution imaging of intact tissues

(2014) Raju Tomer et al.   Nature Protocols

A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System

(2014) Morgane Belle et al.   Cell Reports

Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO

(2014) Ali Ertürk et al.   Jove-Journal of Visualized Experiments

Immune Modulation in Cancer with Antibodies

(2013) David B. Page et al.   Annual Review of Medicine

High-resolution deep imaging of live cellular spheroids with light-sheet-based fluorescence microscopy

(2013) Francesco Pampaloni et al.   CELL AND TISSUE RESEARCH

ClearT: a detergent- and solvent-free clearing method for neuronal and non-neuronal tissue

(2013) T. Kuwajima et al.   DEVELOPMENT

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

(2013) René Hägerling et al.   EMBO JOURNAL

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

(2013) Nicholas G. Horton et al.   Nature Photonics

Light microscopy mapping of connections in the intact brain

(2013) Sung-Yon Kim et al.   TRENDS IN COGNITIVE SCIENCES

High-resolution visualization of mouse cardiac microvasculature using optical histology

(2013) Austin J. Moy et al.   Biomedical Optics Express

High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO)

(2012) Ali Ertürk et al.   EXPERIMENTAL NEUROLOGY

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

Chemical Clearing and Dehydration of GFP Expressing Mouse Brains

(2012) Klaus Becker et al.   PLoS One

Shedding light on the system: studying embryonic development with light sheet microscopy

(2011) Raju Tomer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Light Sheet Fluorescence Microscopy

(2011) Peter A. Santi   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury

(2011) Ali Ertürk et al.   NATURE MEDICINE

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

(2011) Hiroshi Hama et al.   NATURE NEUROSCIENCE

Target-Cancer-Cell-Specific Activatable Fluorescence Imaging Probes: Rational Design and in Vivo Applications

(2010) Hisataka Kobayashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Activatable Molecular Probes for Cancer Imaging

(2010) Seulki Lee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Formalin-Induced Fluorescence Reveals Cell Shape and Morphology in Biological Tissue Samples

(2010) Ulrich Leischner et al.   PLoS One

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges

(2010) Xiaoxiao He et al.   TRENDS IN MOLECULAR MEDICINE

3D-reconstruction of blood vessels by ultramicroscopy

(2010) Nina Jährling et al.   Organogenesis

Selective plane illumination microscopy techniques in developmental biology

(2009) J. Huisken et al.   DEVELOPMENT

Resolution of Ultramicroscopy and Field of View Analysis

(2009) Ulrich Leischner et al.   PLoS One

Oxyradical-induced GFP damage and loss of fluorescence

(2008) Abeer A. Alnuami et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ultramicroscopy: 3D reconstruction of large microscopical specimens

(2008) K. Becker et al.   Journal of Biophotonics