The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice

Endoplasmic reticulum stress enhances fibrosis through IRE1α‐mediated degradation of miR‐150 and XBP‐1 splicing

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Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2

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High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

Antifibrotic Therapies in the Liver

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TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

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Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons

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Deletion of the Collagen-specific Molecular Chaperone Hsp47 Causes Endoplasmic Reticulum Stress-mediated Apoptosis of Hepatic Stellate Cells

(2014) Kunito Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

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Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

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Therapy for Fibrotic Diseases: Nearing the Starting Line

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Endoplasmic Reticulum stress induces hepatic stellate cell apoptosis and contributes to fibrosis resolution

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PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

Involvement of Endoplasmic Reticulum Stress in Myofibroblastic Differentiation of Lung Fibroblasts

(2011) Hyun Ah Baek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Protein export at the ER: loading big collagens into COPII carriers

(2011) Vivek Malhotra et al.   EMBO JOURNAL

Global defects in collagen secretion in aMia3/TANGO1knockout mouse

(2011) Deanna G. Wilson et al.   JOURNAL OF CELL BIOLOGY

cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites

(2011) Kota Saito et al.   MOLECULAR BIOLOGY OF THE CELL

GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

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Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

(2010) Sheng Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis

(2010) Robert C Huebert et al.   LABORATORY INVESTIGATION

TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites

(2009) Kota Saito et al.   CELL

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

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The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

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