Recent advances of adapter proteins in the regulation of heart diseases

Cellular, structural and functional cardiac remodelling following pressure overload and unloading

(2016) Keith Dadson et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The emerging role of Toll-like receptor 4 in myocardial inflammation

(2016) Y Yang et al.   Cell Death & Disease

Adapter proteins regulate insulin resistance and lipid metabolism in obesity

(2016) Zheng Chen   Science Bulletin

P66SHC and Ageing: ROS and TOR?

(2016) Giovambattista Pani   Aging-US

Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity

(2015) Zheng Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The p66ShcA adaptor protein regulates healing after myocardial infarction

(2015) Anton Baysa et al.   BASIC RESEARCH IN CARDIOLOGY

SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload

(2015) Gang Wu et al.   CARDIOVASCULAR RESEARCH

Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis

(2015) J Zhao et al.   CELL DEATH AND DIFFERENTIATION

SH2B3Is a Genetic Determinant of Cardiac Inflammation and FibrosisCLINICAL PERSPECTIVE

(2015) Michael J. Flister et al.   Circulation-Cardiovascular Genetics

Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Positive Regulator of Pathological Cardiac HypertrophyNovelty and Significance

(2015) Xi Jiang et al.   HYPERTENSION

Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene ExpressionNovelty and Significance

(2015) Madhu V. Singh et al.   HYPERTENSION

Exercise for the heart: signaling pathways

(2015) Lichan Tao et al.   Oncotarget

SH2B3Is a Genetic Determinant of Cardiac Inflammation and FibrosisCLINICAL PERSPECTIVE

(2015) Michael J. Flister et al.   Circulation-Cardiovascular Genetics

Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity

(2015) Zheng Chen et al.   Molecular Metabolism

The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity

(2014) Alan Valaperti et al.   BASIC RESEARCH IN CARDIOLOGY

c-Cbl Inhibition Improves Cardiac Function and Survival in Response to Myocardial Ischemia

(2014) Khadija Rafiq et al.   CIRCULATION

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways

(2014) Alexander Akhmedov et al.   EUROPEAN HEART JOURNAL

Cardiac-specific Traf2 overexpression enhances cardiac hypertrophy through activating AKT/GSK3β signaling

(2014) Yinqing Huang et al.   GENE

Toll-Like Receptor-4 Modulates Survival by Induction of Left Ventricular Remodeling after Myocardial Infarction in Mice

(2014) A. Riad et al.   JOURNAL OF IMMUNOLOGY

Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training

(2014) C. Riehle et al.   MOLECULAR AND CELLULAR BIOLOGY

SH2B1 in β-Cells Promotes Insulin Expression and Glucose Metabolism in Mice

(2014) Zheng Chen et al.   MOLECULAR ENDOCRINOLOGY

AdipoR1/APPL1 Potentiates the Protective Effects of Globular Adiponectin on Angiotensin II-Induced Cardiac Hypertrophy and Fibrosis in Neonatal Rat Atrial Myocytes and Fibroblasts

(2014) Tengwei Cao et al.   PLoS One

Inputs and outputs of insulin receptor

(2014) Yipeng Du et al.   Protein & Cell

Role of Extracellular RNA and TLR3‐Trif Signaling in Myocardial Ischemia–Reperfusion Injury

(2014) Chan Chen et al.   Journal of the American Heart Association

Dysferlin Mediates the Cytoprotective Effects of TRAF2 Following Myocardial Ischemia Reperfusion Injury

(2014) Huei‐Ping Tzeng et al.   Journal of the American Heart Association

APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction

(2013) Min Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

(2013) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Tumor Necrosis Factor Receptor–Associated Factor 2 Signaling Provokes Adverse Cardiac Remodeling in the Adult Mammalian Heart

(2013) Vijay G. Divakaran et al.   Circulation-Heart Failure

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38  MAPK During Insulin Resistance

(2013) Y. Qi et al.   DIABETES

SH2B1 in  -Cells Regulates Glucose Metabolism by Promoting  -Cell Survival and Islet Expansion

(2013) Z. Chen et al.   DIABETES

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway

(2012) Antonio Cittadini et al.   CARDIOVASCULAR RESEARCH

Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses

(2012) Z. Chen et al.   DIABETES

Cardiac mitochondrial dysfunction during hyperglycemia—The role of oxidative stress and p66Shc signaling

(2012) Catia V. Diogo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction

(2012) Madhu V. Singh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes

(2012) Heiko Bugger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction

(2012) Toyoharu Oba et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of the adaptor protein LNK in normal and malignant hematopoiesis

(2012) S Gery et al.   ONCOGENE

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

(2011) Manlio Vinciguerra et al.   AGING CELL

The TIR/BB-loop mimetic AS-1 prevents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88-dependent signaling

(2011) Yun Zhu et al.   BASIC RESEARCH IN CARDIOLOGY

The adaptor Lnk (SH2B3): An emerging regulator in vascular cells and a link between immune and inflammatory signaling

(2011) Julie Devallière et al.   BIOCHEMICAL PHARMACOLOGY

Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias

(2011) Toshitaka Yajima et al.   CIRCULATION

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G

(2011) Khadija Rafiq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIF Is a Critical Survival Factor in Viral Cardiomyopathy

(2011) A. Riad et al.   JOURNAL OF IMMUNOLOGY

Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction

(2011) Gemma Vilahur et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Innate immune signaling in cardiac ischemia

(2011) Fatih Arslan et al.   Nature Reviews Cardiology

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart

(2010) Xiangping Fang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Toll-Like Receptor 4 Stimulation Initiates an Inflammatory Response That Decreases Cardiomyocyte Contractility

(2010) Orna Avlas et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia

(2010) Reut Fallach et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myocarditis

(2010) Lori A. Blauwet et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase

(2009) Fabio Di Lisa et al.   BASIC RESEARCH IN CARDIOLOGY

Effect of insulin and glucose infusion on myocardial infarction size in uraemic rats

(2009) Ralf Dikow et al.   BASIC RESEARCH IN CARDIOLOGY

Myeloid Differentiation Factor-88/Interleukin-1 Signaling Controls Cardiac Fibrosis and Heart Failure Progression in Inflammatory Dilated Cardiomyopathy

(2009) Przemyslaw Blyszczuk et al.   CIRCULATION RESEARCH

SH2B1 Enhances Insulin Sensitivity by Both Stimulating the Insulin Receptor and Inhibiting Tyrosine Dephosphorylation of Insulin Receptor Substrate Proteins

(2009) D. L. Morris et al.   DIABETES

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

ROLE OF INSULIN-LIKE GROWTH FACTOR 1 AND PHOSPHOINOSITIDE 3-KINASE IN A SETTING OF HEART DISEASE

(2008) Julie R McMullen   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY