Role of the adaptor protein LNK in normal and malignant hematopoiesis

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells

(2012) Jing Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke

(2012) H. Ahlenius et al.   JOURNAL OF NEUROSCIENCE

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

(2012) Ying Jin et al.   NATURE GENETICS

Novel Associations for Hypothyroidism Include Known Autoimmune Risk Loci

(2012) Nicholas Eriksson et al.   PLoS One

Possible new LNK mutations in myeloproliferative neoplasms

(2011) Jung-Sook Ha et al.   AMERICAN JOURNAL OF HEMATOLOGY

A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosis

(2011) Mary Frances McMullin et al.   AMERICAN JOURNAL OF HEMATOLOGY

Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling

(2011) Saskia Gueller et al.   EXPERIMENTAL HEMATOLOGY

Myeloproliferative Neoplasms: Molecular Pathophysiology, Essential Clinical Understanding, and Treatment Strategies

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Clonal hierarchy and allelic mutation segregation in a myelofibrosis patient with two distinct LNK mutations

(2011) T L Lasho et al.   LEUKEMIA

LNK can also be mutated outside PH and SH2 domains in myeloproliferative neoplasms with and without V617FJAK2 mutation

(2011) C. Hurtado et al.   LEUKEMIA RESEARCH

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

(2011) Chung Yeng Looi et al.   PLoS One

The Adaptor Protein SH2B3 (Lnk) Negatively Regulates Neurite Outgrowth of PC12 Cells and Cortical Neurons

(2011) Tien-Cheng Wang et al.   PLoS One

Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection

(2010) Alexandra Zhernakova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases

(2010) F. Toffalini et al.   BLOOD

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

(2010) F. Baran-Marszak et al.   BLOOD

Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice

(2010) David L. Morris et al.   ENDOCRINOLOGY

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis

(2010) A Alcina et al.   GENES AND IMMUNITY

Lnk constrains myeloproliferative diseases in mice

(2010) Alexey Bersenev et al.   JOURNAL OF CLINICAL INVESTIGATION

Lnk-dependent axis of SCF–cKit signal for osteogenesis in bone fracture healing

(2010) Tomoyuki Matsumoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

(2010) Saskia Gueller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

LNK mutation studies in blast-phase myeloproliferative neoplasms and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations

(2010) A Pardanani et al.   LEUKEMIA

Dysregulated Gene Expression During Hematopoietic Differentiation From Human Embryonic Stem Cells

(2010) Gautam Dravid et al.   MOLECULAR THERAPY

LNKMutations inJAK2Mutation–Negative Erythrocytosis

(2010) Terra L. Lasho et al.   NEW ENGLAND JOURNAL OF MEDICINE

The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients

(2010) Elena Y Lavrikova et al.   PEDIATRIC DIABETES

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Pivotal Role of Lnk Adaptor Protein in Endothelial Progenitor Cell Biology for Vascular Regeneration

(2009) Sang-Mo Kwon et al.   CIRCULATION RESEARCH

Expression of the adaptor protein Lnk in leukemia cells

(2009) Sigal Gery et al.   EXPERIMENTAL HEMATOLOGY

Common and different genetic background for rheumatoid arthritis and coeliac disease

(2009) Marieke J.H. Coenen et al.   HUMAN MOLECULAR GENETICS

Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

(2009) Hitoshi Takizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

(2009) Sigal Gery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Adaptor protein Lnk associates with Tyr568in c-Kit

(2008) Saskia Gueller et al.   BIOCHEMICAL JOURNAL

Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells

(2008) C. Simon et al.   BLOOD

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

(2008) Hitoshi Takizawa et al.   EXPERIMENTAL HEMATOLOGY

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE