Autoimmunity in Pulmonary Arterial Hypertension: Evidence for Local Immunoglobulin Production

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation

(2020) Xian Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular sources of IL-6 and associations with clinical phenotypes and outcomes in PAH

(2020) Catherine E. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

IgA subclasses have different effector functions associated with distinct glycosylation profiles

(2020) Ulrike Steffen et al.   Nature Communications

DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice

(2020) Thomas Koudstaal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages

(2020) Daile Jia et al.   CIRCULATION RESEARCH

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Dendritic Cell Subsets and Effector Function in Idiopathic and Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

(2019) Denise van Uden et al.   Frontiers in Immunology

Fcμ receptor as a Costimulatory Molecule for T Cells

(2019) Andreas Meryk et al.   Cell Reports

Fcγ Receptor Type I (CD64)-Mediated Impairment of the Capacity of Dendritic Cells to Activate Specific CD8 T Cells by IgG-opsonized Friend Virus

(2019) Zoltán Bánki et al.   Viruses-Basel

Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin

(2019) Lei Wang et al.   THORAX

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

(2019) Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CCR2/CCR5-Mediated Macrophage-Smooth Muscle Cell Crosstalk in Pulmonary Hypertension

(2019) Shariq Abid et al.   EUROPEAN RESPIRATORY JOURNAL

Functional Roles of the IgM Fc Receptor in the Immune System

(2019) Hiromi Kubagawa et al.   Frontiers in Immunology

Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension

(2019) Maria G Frid et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Current insights into the mechanism of mammalian immunoglobulin class switch recombination

(2019) Kefei Yu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments

(2019) Thomas Korn et al.   Frontiers in Immunology

IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR-424/503 in vitro

(2018) Koichi Takagi et al.   CELLULAR SIGNALLING

Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary HypertensionNovelty and Significance

(2018) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension

(2018) Lisa K. Blum et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension

(2018) Leigh M. Marsh et al.   EUROPEAN RESPIRATORY JOURNAL

Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension

(2018) Soni Savai Pullamsetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice

(2018) Guilin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells

(2018) Jie Liu et al.   EBioMedicine

Prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma – A review

(2018) José Pedro L. Nunes et al.   AUTOIMMUNITY REVIEWS

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

(2017) Liam A. Hurst et al.   Nature Communications

CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System

(2017) Benjamin D. Clarkson et al.   Scientific Reports

Neutrophil Extracellular Traps Promote AngiogenesisHighlights

(2016) Lulwah Aldabbous et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in AgedApoE−/−MiceHighlights

(2016) Prasad Srikakulapu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

(2016) Pawan Kumar et al.   IMMUNITY

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability

(2016) Stoyan Ivanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Inflammation and γδ T Cells

(2016) Nathan S. Fay et al.   Frontiers in Immunology

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension

(2015) Isabel Diebold et al.   Cell Metabolism

Fc  Receptors and Ligands and Cardiovascular Disease

(2015) K. Tanigaki et al.   CIRCULATION RESEARCH

Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice

(2015) C. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension

(2015) Yoshiharu Sada et al.   HEART AND VESSELS

Mast cell progenitors: Origin, development and migration to tissues

(2015) Joakim S. Dahlin et al.   MOLECULAR IMMUNOLOGY

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis

(2014) Sarajo Kumar Mohanta et al.   CIRCULATION RESEARCH

IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms

(2014) J. Wang et al.   EMBO Molecular Medicine

Mast cell activation: A complex interplay of positive and negative signaling pathways

(2014) Riccardo Sibilano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells protect against hypoxia-induced pulmonary arterial hypertension in mice

(2014) YANBIAO CHU et al.   Molecular Medicine Reports

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Bronchus-associated Lymphoid Tissue in Pulmonary Hypertension Produces Pathologic Autoantibodies

(2013) Kelley L. Colvin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension

(2013) Steven J. Arends et al.   AUTOIMMUNITY

Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?

(2013) S. J. Arends et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human dendritic cell subsets

(2013) Matthew Collin et al.   IMMUNOLOGY

Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension

(2012) Rajkumar Savai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severe Pulmonary Arterial Hypertension Induced by SU5416 and Ovalbumin Immunization

(2012) Shiro Mizuno et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inflammation in Pulmonary Arterial Hypertension

(2012) Laura C. Price et al.   CHEST

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Th17 Cells Upregulate Polymeric Ig Receptor and Intestinal IgA and Contribute to Intestinal Homeostasis

(2012) Anthony T. Cao et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells and Pulmonary Hypertension

(2012) Rasa Tamosiuniene et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Mast Cell Number, Phenotype, and Function in Human Pulmonary Arterial Hypertension

(2012) Samar Farha et al.   Pulmonary Circulation

Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation

(2011) Karl-Otto Larsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

C-Kit–Positive Cells Accumulate in Remodeled Vessels of Idiopathic Pulmonary Arterial Hypertension

(2011) David Montani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Lymphoid Neogenesis in Idiopathic Pulmonary Arterial Hypertension

(2011) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction

(2011) Guillaume Bussone et al.   ANNALS OF THE RHEUMATIC DISEASES

Mast Cell Inhibition Improves Pulmonary Vascular Remodeling in Pulmonary Hypertension

(2011) Beatrijs Bartelds et al.   CHEST

Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension

(2011) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma

(2011) Hanadi Dib et al.   EUROPEAN RESPIRATORY JOURNAL

Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis

(2011) Sebahat Ocak et al.   EUROPEAN RESPIRATORY JOURNAL

Alteration of fibroblast phenotype by asbestos-induced autoantibodies

(2011) Jean C. Pfau et al.   Journal of Immunotoxicology

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Complement C3 Deficiency Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in Mice

(2011) Eileen M. Bauer et al.   PLoS One

Prevalence of anti-endothelial cell antibodies in idiopathic pulmonary arterial hypertension

(2010) S. J. Arends et al.   EUROPEAN RESPIRATORY JOURNAL

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small airway obstruction in severe pulmonary arterial hypertension correlates with increased airway CD8+ T-cells and fractalkine expression

(2009) C. Ars et al.   EUROPEAN RESPIRATORY JOURNAL

Impairment of Monocyte-derived Dendritic Cells in Idiopathic Pulmonary Arterial Hypertension

(2009) Weiyan Wang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching

(2009) M. Kashiwada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension

(2009) E.D. Austin et al.   RESPIRATORY MEDICINE

Identification of Target Antigens of Antifibroblast Antibodies in Pulmonary Arterial Hypertension

(2008) Benjamin Terrier et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4

(2008) Serena Fineschi et al.   ARTHRITIS AND RHEUMATISM

Interaction of Human C1q with IgG and IgM: Revisited†

(2008) Mihaela G. Gadjeva et al.   BIOCHEMISTRY

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Pulmonary arterial remodeling induced by a Th2 immune response

(2008) Eleen Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Regulatory and Decreased CD8+ Cytotoxic T Cells in the Blood of Patients with Idiopathic Pulmonary Arterial Hypertension

(2007) Silvia Ulrich et al.   RESPIRATION