Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia

BCL2 blockade overcomes MCL1 resistance in multiple myeloma

(2019) Ka Tat Siu et al.   LEUKEMIA

FLT3/ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways

(2019) Min Wu et al.   HAEMATOLOGICA

Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-mutated Acute Myeloid Leukemia

(2019) Jun Ma et al.   CLINICAL CANCER RESEARCH

The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

(2019) Tom Kunschmann et al.   Scientific Reports

PFN1 Induces drug resistance through Beclin1 Complex mediated autophagy in multiple myeloma

(2018) Yichen Lu et al.   CANCER SCIENCE

Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics

(2018) G.A. Cardama et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Deregulation of linc-PINT in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells

(2018) Andoni Garitano-Trojaola et al.   Oncotarget

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity

(2018) Antoun Al Absi et al.   CANCER RESEARCH

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

(2018) Donia M. Moujalled et al.   LEUKEMIA

Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function

(2018) Alessia Castagnino et al.   ONCOGENE

Cyanine Conformational Restraint in the Far-Red Range

(2017) Megan S. Michie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new strategy to measure intercellular adhesion forces in mature cell-cell contacts

(2017) Ana Sancho et al.   Scientific Reports

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome

(2016) Vaia Stavropoulou et al.   CANCER CELL

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways

(2016) Gang Li et al.   Oncotarget

PathCards: multi-source consolidation of human biological pathways

(2015) Frida Belinky et al.   Database-The Journal of Biological Databases and Curation

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

(2015) Yi-Yu Ke et al.   Scientific Reports

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

(2014) Thuy V. Nguyen et al.   BIOMATERIALS

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

(2014) Anindya Chatterjee et al.   Cell Reports

Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs

(2013) Silviya Zustiak et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia

(2012) A. B. Williams et al.   BLOOD

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

rapidSTORM: accurate, fast open-source software for localization microscopy

(2012) Steve Wolter et al.   NATURE METHODS

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

(2011) R. Velaithan et al.   BLOOD

Correlative nanomechanical profiling with super-resolution F-actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells

(2011) Shivani Sharma et al.   Nanomedicine-Nanotechnology Biology and Medicine

Arp2/3 complex is bound and activated by two WASP proteins

(2011) S. B. Padrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation State-Dependent Binding of Small Molecule Kinase Inhibitors: Structural Insights from Biochemistry

(2010) Lisa M. Wodicka et al.   CHEMISTRY & BIOLOGY

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma

(2009) A. K. Azab et al.   BLOOD

ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside

(2009) Jianbiao Zhou et al.   Journal of Hematology & Oncology

FluidFM: Combining Atomic Force Microscopy and Nanofluidics in a Universal Liquid Delivery System for Single Cell Applications and Beyond

(2009) André Meister et al.   NANO LETTERS