Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism

(2020) Isha H. Jain et al.   CELL

Inside the hypoxic tumour: reprogramming of the DDR and radioresistance

(2020) Katheryn Begg et al.   Cell Death Discovery

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Nuclear genetic regulation of the human mitochondrial transcriptome

(2019) Aminah T Ali et al.   eLife

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data

(2018) Nadezhda T. Doncheva et al.   JOURNAL OF PROTEOME RESEARCH

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function

(2018) Thomas Briston et al.   Frontiers in Oncology

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

Emerging and evolving concepts in gene essentiality

(2017) Giulia Rancati et al.   NATURE REVIEWS GENETICS

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

(2017) Luke W. Thomas et al.   Frontiers in Oncology

Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries

(2017) Swee Hoe Ong et al.   Scientific Reports

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

(2016) G. Laurenti et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

(2016) Jason D. Arroyo et al.   Cell Metabolism

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

The Cost of Protein Production

(2016) Moshe Kafri et al.   Cell Reports

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime

(2015) Hiromi Kurokawa et al.   Scientific Reports

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

(2015) Edward L. LaGory et al.   Cell Reports

Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment

(2013) Jakub Rohlena et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

(2013) Luisa Iommarini et al.   HUMAN MOLECULAR GENETICS

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

clusterMaker: a multi-algorithm clustering plugin for Cytoscape

(2012) John H Morris et al.   BMC BIOINFORMATICS

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

(2012) Jun Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

Role of ATP-Hydrolysis in the Dynamics of a Single Actin Filament

(2010) Padinhateeri Ranjith et al.   BIOPHYSICAL JOURNAL

Lack of Oxygen Deactivates Mitochondrial Complex I

(2009) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY