Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

AT2R’s (Angiotensin II Type 2 Receptor’s) Role in Cognitive and Cerebrovascular Deficits in a Mouse Model of Alzheimer Disease

(2020) Jessika Royea et al.   HYPERTENSION

Impact of the Hereditary P301L Mutation on the Correlated Conformational Dynamics of Human Tau Protein Revealed by the Paramagnetic Relaxation Enhancement NMR Experiments

(2020) Ryosuke Kawasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

(2020) Ying-Wooi Wan et al.   Cell Reports

Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm

(2020) Yang Li et al.   CIRCULATION RESEARCH

Racial Differences in Dietary Relations to Cognitive Decline and Alzheimer’s Disease Risk: Do We Know Enough?

(2020) Puja Agarwal et al.   Frontiers in Human Neuroscience

Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

(2020) Daniel J. Tyrrell et al.   Nature Reviews Cardiology

Common Brain Structural Alterations Associated with Cardiovascular Disease Risk Factors and Alzheimer’s Dementia: Future Directions and Implications

(2020) Melissa Lamar et al.   NEUROPSYCHOLOGY REVIEW

Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers rescue memory defects in Drosophila expressing Alzheimer’s disease-related transgenes independently of the canonical Renin Angiotensin System

(2020) Shin-Hann Lee et al.   eNeuro

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Effect of antihypertensive drugs on cognition and behavioral symptoms of patients with Alzheimer’s disease: A meta-analysis

(2020) Roja Rahimi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease

(2020) Shorena Janelidze et al.   JAMA Neurology

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

(2019) Nicolas R. Barthélemy et al.   Frontiers in Aging Neuroscience

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?

(2019) Govindpani et al.   Journal of Clinical Medicine

The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System

(2019) Seunghee Kim et al.   Biomolecules & Therapeutics

Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

(2019) David E. Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Insight into the Structure of the “Unstructured” Tau Protein

(2019) Konstantin I. Popov et al.   STRUCTURE

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections

(2018) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Vascular Hypothesis of Alzheimer’s Disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging

(2018) Jack de la Torre   JOURNAL OF ALZHEIMERS DISEASE

New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective

(2018) Balázs Pósfai et al.   NEUROSCIENCE

Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

(2018) Keren Asraf et al.   Frontiers in Cellular Neuroscience

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

(2018) Victoria Navarro et al.   Frontiers in Aging Neuroscience

Phosphorylation of different tau sites during progression of Alzheimer’s disease

(2018) Joerg Neddens et al.   Acta Neuropathologica Communications

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

(2018) Agne Frismantiene et al.   CELLULAR SIGNALLING

Cellular and Molecular Heterogeneity Associated with Vessel Formation Processes

(2018) Pollyana Ribeiro Castro et al.   Biomed Research International

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Cerebral Amyloid Angiopathy

(2017) Christopher V. DeSimone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of clusterin in the brain vascular clearance of amyloid-β

(2017) Amy R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signature of an aggregation-prone conformation of tau

(2017) Neil A. Eschmann et al.   Scientific Reports

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

(2017) Aurélien Lathuilière et al.   Scientific Reports

Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform

(2016) Yehia M. Ibrahim et al.   ANALYTICAL CHEMISTRY

Hereditary Influence in Thoracic Aortic Aneurysm and Dissection

(2016) Eric M. Isselbacher et al.   CIRCULATION

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

(2016) Irene López González et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

Vascular smooth muscle cell differentiation from human stem/progenitor cells

(2016) Sarah K. Steinbach et al.   METHODS

Origin and differentiation of vascular smooth muscle cells

(2015) Gang Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

(2014) David A. Bennett et al.   BIOCHEMICAL PHARMACOLOGY

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Global Epidemiology of Dementia: Alzheimer’s and Vascular Types

(2014) Liara Rizzi et al.   Biomed Research International

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

(2013) Joshua K. Salabei et al.   BIOCHEMICAL JOURNAL

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

(2013) Jon B. Toledo et al.   BRAIN

Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990–2010: a systematic review and analysis

(2013) Kit Yee Chan et al.   LANCET

A Shift in Microglial β-Amyloid Binding in Alzheimer's Disease Is Associated with Cerebral Amyloid Angiopathy

(2012) Matthew Zabel et al.   BRAIN PATHOLOGY

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation

(2011) Christopher P. Mack   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization

(2011) Dong Xu et al.   BIOPHYSICAL JOURNAL

FGF-23 Associates with Death, Cardiovascular Events, and Initiation of Chronic Dialysis

(2011) J. Kendrick et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Large-Scale Application of High-Throughput Molecular Mechanics with Poisson−Boltzmann Surface Area for Routine Physics-Based Scoring of Protein−Ligand Complexes

(2009) Scott P. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prevalence of Dementia and Its Subtypes in an Elderly Urban Korean Population: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

(2008) Jin Hyeong Jhoo et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity

(2008) Kryslaine O. Lopes et al.   GLIA

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY

Gender-Specific Neuroimmunoendocrine Aging in a Triple-Transgenic 3×Tg-AD Mouse Model for Alzheimer’s Disease and Its Relation with Longevity

(2008) Lydia Giménez-Llort et al.   NEUROIMMUNOMODULATION

Dual Regulation of Cofilin Activity by LIM Kinase and Slingshot-1L Phosphatase Controls Platelet-Derived Growth Factor–Induced Migration of Human Aortic Smooth Muscle Cells

(2007) Alejandra San Martín et al.   CIRCULATION RESEARCH

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation