Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin

A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways

(2021) Wen-Tsan Chang et al.   Oxidative Medicine and Cellular Longevity

Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis

(2021) Elena Andreucci et al.   RHEUMATOLOGY

Lymphatic Vasculature: An Emerging Therapeutic Target and Drug Delivery Route

(2021) Wenjing Xu et al.   Annual Review of Medicine

Mechanosensation and Mechanotransduction by Lymphatic Endothelial Cells Act as Important Regulators of Lymphatic Development and Function

(2021) László Bálint et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

(2021) Taija Mäkinen et al.   CIRCULATION RESEARCH

Effect of Estrogen on Heteronemin-Induced Anti-proliferative Effect in Breast Cancer Cells With Different Estrogen Receptor Status

(2021) Yu-Chen S. H. Yang et al.   Frontiers in Cell and Developmental Biology

The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective

(2020) Cristina Casalou et al.   Frontiers in Cell and Developmental Biology

Adipose-Derived Stem Cells Promote Intussusceptive Lymphangiogenesis by Restricting Dermal Fibrosis in Irradiated Tissue of Mice

(2020) Ryohei Ogino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined Treatment of Heteronemin and Tetrac Induces Antiproliferation in Oral Cancer Cells

(2020) Chi-Hung Huang et al.   Marine Drugs

HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-κB signaling activation in cervical carcinoma

(2020) Jueming Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two Birds, One Stone: Double Hits on Tumor Growth and Lymphangiogenesis by Targeting Vascular Endothelial Growth Factor Receptor 3

(2019) Ming-Chuan Hsu et al.   Cells

Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells

(2019) Huai-Ching Tai et al.   Marine Drugs

Receptor-Interacting Protein Kinase 1 Promotes Cholangiocarcinoma Proliferation And Lymphangiogenesis Through The Activation Protein 1 Pathway

(2019) Cheng-Zong Li et al.   OncoTargets and Therapy

WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

(2019) Shiu-Wen Huang et al.   Frontiers in Oncology

RACK1 promotes the invasive activities and lymph node metastasis of cervical cancer via galectin-1

(2019) Hao Wu et al.   CANCER LETTERS

Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa

(2018) Shu-Rong Chen et al.   Marine Drugs

Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90

(2018) Man-Gang Lee et al.   Marine Drugs

Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression

(2018) Yu-Cheng Chen et al.   Marine Drugs

Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras

(2018) Minakshi Saikia et al.   Oncotarget

Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction

(2018) Jin Gu Cho et al.   Frontiers in Immunology

The therapeutic potential of targeting the endothelial-to-mesenchymal transition

(2018) Shirley Man et al.   ANGIOGENESIS

Roles of the TGF-β–VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis

(2018) Hiroshi Kinashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition

(2018) Orawin Prangsaengtong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-β Pathway

(2018) Hung-Yun Lin et al.   Marine Drugs

Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma

(2018) Jinrong Zhu et al.   ONCOGENE

Brain-derived neurotrophic factor promotes VEGF-C-dependent lymphangiogenesis by suppressing miR-624-3p in human chondrosarcoma cells

(2017) Chih-Yang Lin et al.   Cell Death & Disease

Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration

(2017) Yueh-Chien Lin et al.   Scientific Reports

Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway

(2016) M García-Caballero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Improvement and enhancement of antibladder carcinoma cell effects of heteronemin by the nanosized hyaluronan aggregation

(2016) Han Hsiang Huang et al.   International Journal of Nanomedicine

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells

(2016) Jinlong Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells

(2016) S-H Wang et al.   ONCOGENE

Heteronemin Is a Novel c-Met/STAT3 Inhibitor Against Advanced Prostate Cancer Cells

(2016) Jian-Ching Wu et al.   PROSTATE

Adrenomedullin in lymphangiogenesis: from development to disease

(2015) Klara R. Klein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma

(2015) Hongming Teng et al.   Marine Drugs

Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells

(2015) Szu-Ying Wu et al.   Biomed Research International

Secretion of VEGF-165 has unique characteristics, including shedding from the plasma membrane

(2014) Maria Luisa Guzmán-Hernández et al.   MOLECULAR BIOLOGY OF THE CELL

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

(2012) Yu-Chia Chang et al.   Marine Drugs

Vascular Endothelial Growth Factor Receptor-3 Directly Interacts with Phosphatidylinositol 3-Kinase to Regulate Lymphangiogenesis

(2012) Sanja Coso et al.   PLoS One

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis

(2010) Luqing Zhang et al.   CELL RESEARCH

Vascular Endothelial Growth Factor Receptor-2 Activates ADP-ribosylation Factor 1 to Promote Endothelial Nitric-oxide Synthase Activation and Nitric Oxide Release from Endothelial Cells

(2010) Zeinab Daher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

(2009) Marc Schumacher et al.   BIOCHEMICAL PHARMACOLOGY