Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

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Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients

(2020) Shanshan Pei et al.   Cancer Discovery

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

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Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

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Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

(2019) Heikki Kuusanmäki et al.   HAEMATOLOGICA

Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML

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Clinical Significance of ABCB1 in Acute Myeloid Leukemia: A Comprehensive Study

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Shutting Down Acute Myeloid Leukemia and Myelodysplastic Syndrome with BCL-2 Family Protein Inhibition

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(2018) Courtney D. DiNardo et al.   BLOOD

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(2018) Jeffrey W. Tyner et al.   NATURE

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(2017) Juho Piironen et al.   Electronic Journal of Statistics

HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

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(2016) Paul Geeleher et al.   NATURE

Safikhani et al. reply

(2016) Zhaleh Safikhani et al.   NATURE

Safikhani et al. reply

(2016) Zhaleh Safikhani et al.   NATURE

Safikhani et al. reply

(2016) Zhaleh Safikhani et al.   NATURE

Genic insights from integrated human proteomics in GeneCards

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Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia

(2016) Kevin H. Lin et al.   Scientific Reports

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(2015) Petr Smirnov et al.   BIOINFORMATICS

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

(2015) H. Dombret et al.   BLOOD

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

(2015) Matthew G Rees et al.   Nature Chemical Biology

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

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(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

(2015) B. Seashore-Ludlow et al.   Cancer Discovery

Regularization Paths for Generalized Linear Models via Coordinate Descent

(2015) Jerome Friedman et al.   Journal of Statistical Software

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(2015) Christian Ritz et al.   PLoS One

Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199

(2014) X Niu et al.   LEUKEMIA

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(2014) Bhagwan Yadav et al.   Scientific Reports

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Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

(2013) N. Rapin et al.   BLOOD

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(2013) Benjamin Haibe-Kains et al.   NATURE

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

(2013) R. Pan et al.   Cancer Discovery

Pro-Inflammatory S100A8 and S100A9 Proteins: Self-Assembly into Multifunctional Native and Amyloid Complexes

(2012) Thomas Vogl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Effect of Size and Heterogeneity of Samples on Biomarker Discovery: Synthetic and Real Data Assessment

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Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex

(2011) M Konopleva et al.   LEUKEMIA

Integrative analysis of multiple cancer prognosis studies with gene expression measurements

(2011) Shuangge Ma et al.   STATISTICS IN MEDICINE

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(2010) L. Ziegler-Heitbrock et al.   BLOOD

Maternally Expressed Gene 3, an Imprinted Noncoding RNA Gene, Is Associated with Meningioma Pathogenesis and Progression

(2010) X. Zhang et al.   CANCER RESEARCH

Stable feature selection for biomarker discovery

(2010) Zengyou He et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

FAM129B/MINERVA, a Novel Adherens Junction-associated Protein, Suppresses Apoptosis in HeLa Cells

(2010) Song Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

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(2009) Andreas Buness et al.   BMC BIOINFORMATICS

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH