Article
Biochemistry & Molecular Biology
Lindy J. Pence, Antonis Kourtidis, Ryan W. Feathers, Mary T. Haddad, Sotiris Sotiriou, Paul A. Decker, Aziza Nassar, Idris T. Ocal, Sejal S. Shah, Panos Z. Anastasiadis
Summary: Inflammatory breast cancer expresses high levels of E-cadherin, which promotes tumor metastasis, while the apical adherens junction protein PLEKHA7 is frequently deregulated in this cancer, with re-expression leading to suppression of tumor growth. These findings highlight the potential therapeutic value of targeting the imbalance between apical and basolateral cadherin complexes in inflammatory breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Pureun-Haneul Lee, Seon Muk Choi, Min Hyeok An, Da Yeon Hwang, Shinhee Park, Ae Rin Baek, An-Soo Jang
Summary: This study discovered that Nectin4 levels in the blood of asthmatic patients were significantly increased and correlated with clinical variables. The experimental results indicated that Nectin4 is involved in airway inflammation and may serve as a therapeutic target in patients with asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yinliang Bai, Honghua Zhang, Yali Wang, Longqing Zhu, Tao Shi, Hangzhi Wei, Jiyuan Xiao, Youcheng Zhang, Zhen Wang
Summary: The study demonstrated the potential anticancer therapeutic efficacy of VO(hntdtsc)(NPIP) by inhibiting cell proliferation and inducing cell apoptosis, showing strong antitumor activity both in vitro and in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Aipeng Mao, Weigang Zhao, Yuhang Zhu, Fantao Kong, Danyang Chen, Huazhe Si, Chao Xu
Summary: This study analyzed the clinical symptoms and pathogenesis of a DSS-induced canine IBD model and evaluated the restorative effect of ginsenoside. The findings revealed that dogs with IBD exhibited decreased mental state, disrupted colonic tissue structure, and reduced diversity of the colonic mucosal bacterial community. Ginsenoside treatment improved these symptoms and reversed the relative abundance of some bacterial communities.
Article
Chemistry, Medicinal
Daniella Paiva Bonfim, Celso Vataru Nakamura, Joao Xavier de Araujo Junior, Greisiele Lorena Pessini, Paulo Emilio Correa Leite, Jose Andres Morgado-Diaz, Fernanda Leve
Summary: The study confirmed the anti-proliferation and migration effects of kopsanone on HCT-116 cells through modulation of cell adhesion proteins.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, General & Internal
Miao Li, Di-Sheng Zhou, Xin-Rong Shao, Sze-Hoi Chan, Zhao-Xia Dong, Xue-Qi Liu, Shu-Na Chen, Lin Qi, Luis Velasquez Zarate, Xiao-Mei Wang, Xin Du, Xing-Ding Zhang
Summary: TJP1 down-regulation is significantly associated with high grade and poor prognosis in kidney renal clear cell carcinoma (KIRC). TJP1 may suppress cell proliferation and tumor growth by inducing autophagy signaling.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Food Science & Technology
Simin Chen, Claudia Figueiredo Lossio, Isabel Verbeke, Joost Verduijn, Bogdan Parakhonskiy, Louis Van der Meeren, Pengyu Chen, Jeroen De Zaeytijd, Andre G. Skirtach, Els J. M. Van Damme
Summary: The study found that OsRIP1 can inhibit protein synthesis in a sustained manner, leading to reduced proliferation of HeLa cells with apoptotic-like changes in the cell membrane, but without causing DNA fragmentation. OsRIP1 also interacts with ASPP1 and IFITM3, causing changes in the transcription levels of important genes in the cells, inducing a caspase-independent cell death process in HeLa cells.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Marja Kornhuber, Sebastian Dunst, Gilbert Schoenfelder, Michael Oelgeschlaeger
Summary: This study introduces a novel high-throughput screening-compatible assay, E-Morph Assay, that accurately predicts the estrogenic potential of environmental chemicals by quantifying changes in the cell contact morphology of human breast cancer cells. The assay classifies substances into four main categories of estrogenic activity based on a classification model developed using reference substances.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Lizebona August Ambattu, Callum Knight, Keng-hui Lin, Amy Gelmi, Leslie Y. Yeo
Summary: This study investigates the effects of short-duration mechanostimulation on endothelial junction stability and barrier capacity. The study found that the integrity of the endothelial barrier can not only recover but also enhance considerably after transient disruption, thanks to the role of calcium and cAMP signaling. Such enhancement in barrier capacity is useful for developing in vitro models that resemble in vivo conditions.
Article
Environmental Sciences
Man Zhang, Qinghao Li, Jun Wang, Juan Sun, Yuqiang Xiang, Xin Jin
Summary: The study demonstrates that aflatoxin B1 (AFB1) has negative effects on intestinal barrier function, leading to cellular toxicity and apoptosis, as well as impacting the structural integrity and protein expression in the intestine.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Rong Fu, Xiaowan Jiang, Gang Li, Yi Zhu, Huimin Zhang
Summary: The cell-cell and cell-ECM junctions in epithelial tissues play crucial roles in providing architectural stability, mechanical resistance, and permeability control, as well as regulating innate immune defense, stress resistance, and intracellular proteostasis of epithelial cells. Their multitasking nature extends beyond anchorage-dependent or cell shape change-related processes.
Article
Plant Sciences
Patricia alvarez-Ortiz, Juan Ascacio-Valdes, Ileana Vera-Reyes, Cecilia Esparza-Gonzalez, Raul Rodriguez-Herrera, Mauricio Salinas-Santander, Mayela del angel-Martinez, Antonio Morlett-Chavez
Summary: This study evaluated the therapeutic effect of a P. plicata extract on the HeLa cell line and found that the extract treatment deregulated cell viability and induced various apoptotic morphologies associated with bio-compounds, which regulated proteins associated with apoptosis in cancer cells.
Article
Multidisciplinary Sciences
Regina B. Troyanovsky, Alina P. Sergeeva, Indrajyoti Indra, Chi-Shuo Chen, Rei Kato, Lawrence Shapiro, Barry Honig, Sergey M. Troyanovsky
Summary: The study explores the structure and function of the multiprotein complex formed by the cytoplasmic tails of classical cadherins in adherens junctions. It reveals that cytoplasmic proteins interact with this complex and organize into clusters, potentially synchronizing signaling networks among neighboring cells within tissues.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Teng-Long Han, Hang Sha, Jun Ji, Yun-Tian Li, Deng-Shan Wu, Hu Lin, Bin Hu, Zhi-Xin Jiang
Summary: Survivin depletion protects HeLa cells against docetaxel-induced apoptosis by facilitating mitotic slippage, but does not promote clonogenic survival of tumor cells and increases cellular senescence induced by docetaxel. Lentiviral overexpression of Survivin does not protect against docetaxel or cisplatin treatment, suggesting that targeting Survivin may drive cells through aberrant mitotic progression instead of directly sensitizing cells to apoptosis.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Ahsan Anjoom Sunil, Tom Skaria
Summary: This article reviews the endogenous factors and mechanisms that disrupt the airway epithelial barrier during inflammation, and discusses whether these factors can be specifically targeted by repurposing existing drugs.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)