Receptor-based targeting of engineered nanocarrier against solid tumors: Recent progress and challenges ahead

Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy

(2020) Yang Li et al.   JOURNAL OF CONTROLLED RELEASE

Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

(2020) Paul Hoppenz et al.   Frontiers in Chemistry

Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells

(2019) Zar Chi Soe et al.   Pharmaceutics

Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery Systems

(2019) Beatrice Fortuni et al.   Scientific Reports

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

(2019) Justine Habault et al.   MOLECULES

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles

(2019) Valentina Francia et al.   ACS Nano

Targeting integrins for cancer management using nanotherapeutic approaches: Recent advances and challenges

(2019) Khurshid Ahmad et al.   SEMINARS IN CANCER BIOLOGY

Novel therapeutic interventions in cancer treatment using protein and peptide-based targeted smart systems

(2019) Sobiya Zafar et al.   SEMINARS IN CANCER BIOLOGY

Tumor Microenvironment Responsive Shape-Reversal Self-Targeting Virus-Inspired Nanodrug for Imaging-Guided Near-Infrared-II Photothermal Chemotherapy

(2019) Yang Li et al.   ACS Nano

Dual‐Locking Nanoparticles Disrupt the PD‐1/PD‐L1 Pathway for Efficient Cancer Immunotherapy

(2019) Zhanzhan Zhang et al.   ADVANCED MATERIALS

Methotrexate-conjugated chitosan-grafted pH- and thermo-responsive magnetic nanoparticles for targeted therapy of ovarian cancer

(2019) Marziyeh Fathi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

(2019) Zeenat Mirza et al.   SEMINARS IN CANCER BIOLOGY

Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy

(2019) Sibi Raj et al.   SEMINARS IN CANCER BIOLOGY

Protein corona impact on nanoparticle-cell interactions: toward an energy-based model of endocytosis

(2019) P Shadmani et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Nanomedicine in treatment of breast cancer – A challenge to conventional therapy

(2019) Muhammad Afzal et al.   SEMINARS IN CANCER BIOLOGY

Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer

(2018) Tingting Lv et al.   Acta Biomaterialia

Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer

(2018) Pranali Deshpande et al.   DRUG DELIVERY

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

(2018) Wei-Wei Zhang et al.   HUMAN GENE THERAPY

Thermo-sensitive chitosan copolymer-gold hybrid nanoparticles as a nanocarrier for delivery of erlotinib

(2018) Marziyeh Fathi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer

(2018) Chang Liu et al.   MOLECULAR PHARMACEUTICS

Precise targeting of cancer metastasis using multi-ligand nanoparticles incorporating four different ligands

(2018) P. M. Peiris et al.   Nanoscale

Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate

(2018) Manoj Saxena et al.   PLoS One

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

In vitro and in vivo evaluation of folate receptor-targeted a novel magnetic drug delivery system for ovarian cancer therapy

(2018) Güliz Ak et al.   Artificial Cells Nanomedicine and Biotechnology

Anti-proliferate and apoptosis triggering potential of methotrexate-transferrin conjugate encapsulated PLGA nanoparticles with enhanced cellular uptake by high-affinity folate receptors

(2018) Ankush Parmar et al.   Artificial Cells Nanomedicine and Biotechnology

The effects of surface charge on the intra-tumor penetration of drug delivery vehicles with tumor progression

(2018) Donglin Han et al.   Journal of Materials Chemistry B

Main trends of immune effects triggered by nanomedicines in preclinical studies

(2018) Blanka Halamoda-Kenzaoui et al.   International Journal of Nanomedicine

Enhanced endosomal escape by photothermal activation for improved small interfering RNA delivery and antitumor effect

(2018) Xi Yang et al.   International Journal of Nanomedicine

Tumor-specific delivery of therapeutic siRNAs by anti-EGFR immunonanoparticles

(2018) Jung Seok Kim et al.   International Journal of Nanomedicine

Stimuli-responsive nanoscale drug delivery systems for cancer therapy

(2018) Li Li et al.   JOURNAL OF DRUG TARGETING

Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

(2018) Francesco Roncato et al.   Nature Communications

Transferrin receptor-targeted HMSN for sorafenib delivery in refractory differentiated thyroid cancer therapy

(2018) You Ke et al.   International Journal of Nanomedicine

The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme

(2017) Dimitry A. Chistiakov et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

(2017) Fakhar ud Din et al.   International Journal of Nanomedicine

Targeted multidrug delivery system to overcome chemoresistance in breast cancer

(2017) Yuan Tang et al.   International Journal of Nanomedicine

Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy

(2017) Zahra Ranjbar-Navazi et al.   JOURNAL OF DRUG TARGETING

Chimeric antigen receptor T cells: a novel therapy for solid tumors

(2017) Shengnan Yu et al.   Journal of Hematology & Oncology

Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma

(2017) Shanshan Wang et al.   MOLECULAR THERAPY

Ligand-decorated click polypeptide derived nanoparticles for targeted drug delivery applications

(2017) Mohiuddin A. Quadir et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

(2017) Ayse Basak Engin et al.   Particle and Fibre Toxicology

Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona

(2017) Giulio Caracciolo et al.   TRENDS IN BIOTECHNOLOGY

Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics

(2017) Md. Habban Akhter et al.   Artificial Cells Nanomedicine and Biotechnology

An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin

(2017) Md. Habban Akhter et al.   Current Drug Delivery

Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer

(2017) Dan Pu et al.   MEDICAL SCIENCE MONITOR

Folate-conjugated pH-responsive nanocarrier designed for active tumor targeting and controlled release of doxorubicin

(2017) Lulu Wei et al.   Frontiers of Materials Science

Monocytes/Macrophages promote vascular CXCR4 expression via the ERK pathway in hepatocellular carcinoma

(2017) Ya-Ming Meng et al.   OncoImmunology

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

QSAR model for predicting cell viability of human embryonic kidney cells exposed to SiO 2 nanoparticles

(2016) Serena Manganelli et al.   CHEMOSPHERE

Protein corona: Opportunities and challenges

(2016) Saeid Zanganeh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tumor stroma-containing 3D spheroid arrays: A tool to study nanoparticle penetration

(2016) Dwi L. Priwitaningrum et al.   JOURNAL OF CONTROLLED RELEASE

Glioma-targeted therapy using Cilengitide nanoparticles combined with UTMD enhanced delivery

(2016) Ying-Zheng Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Ligand-targeted theranostic nanomedicines against cancer

(2016) Virginia J. Yao et al.   JOURNAL OF CONTROLLED RELEASE

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

(2016) Amrita Banerjee et al.   JOURNAL OF CONTROLLED RELEASE

Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates

(2016) Heather Donaghy   mAbs

Modification of the protein corona–nanoparticle complex by physiological factors

(2016) Nicholas J. Braun et al.   Materials Science & Engineering C-Materials for Biological Applications

Folate-Hapten–Mediated Immunotherapy Synergizes with Vascular Endothelial Growth Factor Receptor Inhibitors in Treating Murine Models of Cancer

(2016) N. Achini Bandara et al.   MOLECULAR CANCER THERAPEUTICS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

Building nanostructures with drugs

(2016) Wang Ma et al.   Nano Today

Emerging understanding of the protein corona at the nano-bio interfaces

(2016) Morteza Mahmoudi et al.   Nano Today

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Simultaneous targeting of Eph receptors in glioblastoma

(2016) Sara Ferluga et al.   Oncotarget

The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches

(2016) Pankita H. Pandya et al.   Journal of Immunology Research

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

(2015) Aaron C. Anselmo et al.   ACS Nano

Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid

(2015) Shaoping Yin et al.   Acta Biomaterialia

Targeted delivery of transferrin and TAT co-modified liposomes encapsulating both paclitaxel and doxorubicin for melanoma

(2015) Mingqing Yuan et al.   DRUG DELIVERY

It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

(2015) Consol Farrera et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Improving drug delivery to solid tumors: Priming the tumor microenvironment

(2015) Iftikhar Ali Khawar et al.   JOURNAL OF CONTROLLED RELEASE

Methotrexate-conjugated quantum dots: synthesis, characterisation and cytotoxicity in drug resistant cancer cells

(2015) Mohammad Johari-Ahar et al.   JOURNAL OF DRUG TARGETING

Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

(2015) Suraj Dixit et al.   Nanoscale

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

Designing a broad-spectrum integrative approach for cancer prevention and treatment

(2015) Keith I. Block et al.   SEMINARS IN CANCER BIOLOGY

Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids

(2015) Hongxu Lu et al.   Biomaterials Science

Engineering and functionalization of biomaterials via surface modification

(2015) Guosong Wu et al.   Journal of Materials Chemistry B

Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells

(2015) Jaleh Barar et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tumor Interstitial Fluid Formation, Characterization, and Clinical Implications

(2015) Marek Wagner et al.   Frontiers in Oncology

Bromelain Surface Modification Increases the Diffusion of Silica Nanoparticles in the Tumor Extracellular Matrix

(2014) Alessandro Parodi et al.   ACS Nano

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

(2014) Caoyun Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery

(2014) Ran Mo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted anticancer therapy: Overexpressed receptors and nanotechnology

(2014) Mohd Javed Akhtar et al.   CLINICA CHIMICA ACTA

Protein corona change the drug release profile of nanocarriers: The “overlooked” factor at the nanobio interface

(2014) Shahed Behzadi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Potentials and Challenges of Active Targeting at the Tumor Cells by Engineered Polymeric Nanoparticles

(2014) Biswajit Mukherjee et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Cancer stem cell: A rogue responsible for tumor development and metastasis

(2014) Sudhir Kumar et al.   INDIAN JOURNAL OF CANCER

Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging

(2014) Benjamin Theek et al.   JOURNAL OF CONTROLLED RELEASE

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Effect of Receptor Occupancy on Folate Receptor Internalization

(2014) N. Achini Bandara et al.   MOLECULAR PHARMACEUTICS

Hyaluronan: Towards novel anti-cancer therapeutics

(2014) Michał S. Karbownik et al.   Pharmacological Reports

Delivering Colloidal Nanoparticles to Mammalian Cells: A Nano-Bio Interface Perspective

(2014) Paolo Verderio et al.   Advanced Healthcare Materials

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models

(2013) Mohammad H. El-Dakdouki et al.   Nanoscale

Structural basis for molecular recognition of folic acid by folate receptors

(2013) Chen Chen et al.   NATURE

The Immunogenicity of Polyethylene Glycol: Facts and Fiction

(2013) Huub Schellekens et al.   PHARMACEUTICAL RESEARCH

Glioma IL13Rα2 Is Associated with Mesenchymal Signature Gene Expression and Poor Patient Prognosis

(2013) Christine E. Brown et al.   PLoS One

EGFRvIII Mediates Hepatocellular Carcinoma Cell Invasion by Promoting S100 Calcium Binding Protein A11 Expression

(2013) Xiaoying Luo et al.   PLoS One

Endocytosis and Cancer

(2013) I. Mellman et al.   Cold Spring Harbor Perspectives in Biology

The endocytosis and intracellular fate of nanomedicines: Implication for rational design

(2013) Longfa Kou et al.   Asian Journal of Pharmaceutical Sciences

Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates

(2012) Li Tang et al.   ACS Nano

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effect of interstitial pressure on tumor growth: Coupling with the blood and lymphatic vascular systems

(2012) Min Wu et al.   JOURNAL OF THEORETICAL BIOLOGY

Effect of PEGylation on Biodistribution and Gene Silencing of siRNA/Lipid Nanoparticle Complexes

(2012) Yanjie Bao et al.   PHARMACEUTICAL RESEARCH

Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

(2011) Vikash P. Chauhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma

(2011) Sarah Minner et al.   CANCER

Recent advances in ligand targeted therapy

(2011) Giuseppe Trapani et al.   JOURNAL OF DRUG TARGETING

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-induced Internalization and Recycling of the Human Neuropeptide Y2Receptor Is Regulated by Its Carboxyl-terminal Tail

(2010) Cornelia Walther et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

(2010) Pål Kristian Selbo et al.   JOURNAL OF CONTROLLED RELEASE

Receptor-targeted nanocarriers for therapeutic delivery to cancer

(2010) Bo Yu et al.   MOLECULAR MEMBRANE BIOLOGY

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Receptor Mediated Tumor Targeting: An Emerging Approach for Cancer Therapy

(2010) Chandana Mohanty et al.   Current Drug Delivery

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

(2010) Masako Ichihara et al.   Pharmaceutics

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

Effects of nanomaterial physicochemical properties on in vivo toxicity

(2009) Kristin L. Aillon et al.   ADVANCED DRUG DELIVERY REVIEWS

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Ligand-based targeted therapy for cancer tissue

(2009) Manasi Das et al.   Expert Opinion on Drug Delivery

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer

(2009) M. Trepel et al.   MOLECULAR CANCER THERAPEUTICS

The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors: Function and Therapeutic Targeting

(2008) J. Wykosky et al.   MOLECULAR CANCER RESEARCH

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

(2008) Michelle Longmire et al.   Nanomedicine