Gut Microbiota and Host Metabolism: From Proof of Concept to Therapeutic Intervention

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

(2021) Francesco Asnicar et al.   NATURE MEDICINE

Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists

(2021) Clara Depommier et al.   Cells

Do diet and microbes really ‘PREDICT’ cardiometabolic risks?

(2021) Patrice D. Cani et al.   Nature Reviews Endocrinology

The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism

(2021) Charlotte Lefort et al.   Cells

Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice

(2021) Tiphaine Le Roy et al.   GUT

Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss

(2020) Lina Lawenius et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

(2020) Julie Rodriguez et al.   GUT

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

(2020) Victoria Meslier et al.   GUT

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

(2020) Yu Xu et al.   Frontiers in Microbiology

Profile of the gut microbiota of adults with obesity: a systematic review

(2020) Louise Crovesy et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?

(2020) Fabien Magne et al.   Nutrients

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

(2020) Moira Marizzoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut microbial metabolites as multi-kingdom intermediates

(2020) Kimberly A. Krautkramer et al.   NATURE REVIEWS MICROBIOLOGY

Gut bacteria Akkermansia is associated with reduced risk of obesity: evidence from the American Gut Project

(2020) Qi Zhou et al.   Nutrition & Metabolism

Comparative Evaluation of Microbiota Engraftment Following Fecal Microbiota Transfer in Mice Models: Age, Kinetic and Microbial Status Matter

(2019) Tiphaine Le Roy et al.   Frontiers in Microbiology

A new genomic blueprint of the human gut microbiota

(2019) Alexandre Almeida et al.   NATURE

The gut microbiome influences host endocrine functions

(2019) Marialetizia Rastelli et al.   ENDOCRINE REVIEWS

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses

(2019) Sara Vieira-Silva et al.   Nature Microbiology

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

(2019) Emily R Leeming et al.   Nutrients

Akkermansia muciniphila reduces Porphyromonas gingivalis ‐induced inflammation and periodontal bone destruction

(2019) Olivier Huck et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

The gut microbiome and elevated cardiovascular risk in obesity and autoimmunity

(2018) Lora J. Kasselman et al.   ATHEROSCLEROSIS

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

(2018) Patrice D. Cani et al.   Nature Reviews Gastroenterology & Hepatology

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

(2018) Yan He et al.   NATURE MEDICINE

US Immigration Westernizes the Human Gut Microbiome

(2018) Pajau Vangay et al.   CELL

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

(2018) Elizabeth A. Kennedy et al.   Frontiers in Physiology

Akkermansia muciniphilainduces gut microbiota remodelling and controls islet autoimmunity in NOD mice

(2017) Arno Hänninen et al.   GUT

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation

(2017) Benoit Chassaing et al.   GUT

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes

(2017) Li Wen et al.   JOURNAL OF NUTRITION

Quantitative microbiome profiling links gut community variation to microbial load

(2017) Doris Vandeputte et al.   NATURE

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Gut microbiota — at the intersection of everything?

(2017) Patrice D. Cani   Nature Reviews Gastroenterology & Hepatology

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

(2017) Patrice D. Cani et al.   Frontiers in Microbiology

Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A Randomized, Double-blind, Controlled Crossover Trial

(2017) Xiuying Zhang et al.   Diabetes Therapy

Effects of Acarbose on the Gut Microbiota of Prediabetic Patients: A Randomized, Double-blind, Controlled Crossover Trial

(2017) Xiuying Zhang et al.   Diabetes Therapy

Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced HyperlipidemiaHighlights

(2016) Jing Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Human Microbiota-Associated Mice: A Model with Challenges

(2016) Marie-Claire Arrieta et al.   Cell Host & Microbe

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE

(2016) Jin Li et al.   CIRCULATION

Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation

(2016) Hilary P. Browne et al.   NATURE

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Cospeciation of gut microbiota with hominids

(2016) A. H. Moeller et al.   SCIENCE

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

(2016) Luisa Möhle et al.   Cell Reports

Characterization of the Gut Microbial Community of Obese Patients Following a Weight-Loss Intervention Using Whole Metagenome Shotgun Sequencing

(2016) Sandrine Louis et al.   PLoS One

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

(2015) Petia Kovatcheva-Datchary et al.   Cell Metabolism

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Relationships between diet-related changes in the gut microbiome and cognitive flexibility

(2015) K.R. Magnusson et al.   NEUROSCIENCE

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

(2012) Hachung Chung et al.   CELL

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight

(2012) Caroline L.J. Karlsson et al.   Obesity

A Core Human Microbiome as Viewed through 16S rRNA Sequence Clusters

(2012) Susan M. Huse et al.   PLoS One

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

(2010) E F Murphy et al.   GUT

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The role of pH in determining the species composition of the human colonic microbiota

(2009) Sylvia H. Duncan et al.   ENVIRONMENTAL MICROBIOLOGY

Microbial community profiling for human microbiome projects: Tools, techniques, and challenges

(2009) M. Hamady et al.   GENOME RESEARCH

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota

(2008) E G Zoetendal et al.   GUT

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA