Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists

Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models

(2021) Clara Depommier et al.   Cells

Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2‐arachidonoyl‐glycerol and its congeners in human myeloid leukocytes

(2020) Caroline Turcotte et al.   FASEB JOURNAL

Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study

(2020) Fabio Arturo Iannotti et al.   MOLECULES

Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function

(2020) Yachen Shen et al.   Cell Reports

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

(2020) Yu Xu et al.   Frontiers in Microbiology

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice

(2020) Clara Depommier et al.   Gut Microbes

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

(2020) Zhiqiang Pang et al.   Metabolites

Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat

(2020) Sophie Castonguay-Paradis et al.   Scientific Reports

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

(2019) Amandine Everard et al.   Nature Communications

Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach

(2019) Enrico D'Aniello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

(2019) Xiaoyuan Bian et al.   Frontiers in Microbiology

Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice

(2019) Fatemeh Ashrafian et al.   Frontiers in Microbiology

The Expanded Endocannabinoid System/Endocannabinoidome as a Potential Target for Treating Diabetes Mellitus

(2019) Alain Veilleux et al.   Current Diabetes Reports

Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome

(2019) Vincenzo Di Marzo et al.   Nutrients

A systematic review of the effects of oleoylethanolamide, a high‐affinity endogenous ligand of PPAR‐α, on the management and prevention of obesity

(2019) Helda Tutunchi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice

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Gut microbiota and obesity: Concepts relevant to clinical care

(2018) Maria Carlota Dao et al.   European Journal of Internal Medicine

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis

(2018) Shreekrishna Lamichane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

(2018) Marialetizia Rastelli et al.   Obesity

New approaches and challenges to targeting the endocannabinoid system

(2018) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα

(2017) Mustafa A. Karwad et al.   FASEB JOURNAL

Akkermansia muciniphilainduces gut microbiota remodelling and controls islet autoimmunity in NOD mice

(2017) Arno Hänninen et al.   GUT

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

Akkermansia muciniphila and its role in regulating host functions

(2017) Muriel Derrien et al.   MICROBIAL PATHOGENESIS

Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model

(2017) Wenrui Wu et al.   Frontiers in Microbiology

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

(2017) Patrice D. Cani et al.   Frontiers in Microbiology

Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity

(2017) Pegah Mehrpouya-Bahrami et al.   Scientific Reports

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

(2016) Joseph F. Pierre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced HyperlipidemiaHighlights

(2016) Jing Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE

(2016) Jin Li et al.   CIRCULATION

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation

(2016) Kathleen L. McCoy   MEDIATORS OF INFLAMMATION

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Talking microbes: When gut bacteria interact with diet and host organs

(2015) Patrice D. Cani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Endocannabinoids — at the crossroads between the gut microbiota and host metabolism

(2015) Patrice D. Cani et al.   Nature Reviews Endocrinology

The Endocannabinoid System and its Modulation by Phytocannabinoids

(2015) Vincenzo Di Marzo et al.   Neurotherapeutics

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

The endocannabinoid system and appetite: relevance for food reward

(2014) Gerry Jager et al.   NUTRITION RESEARCH REVIEWS

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

(2013) Peter M. Zygmunt et al.   PLoS One

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbes inside—from diversity to function: the case of Akkermansia

(2012) Clara Belzer et al.   ISME Journal

Double-check: validation of diagnostic statistics for PLS-DA models in metabolomics studies

(2011) Ewa Szymańska et al.   Metabolomics

Focused Principal Component Analysis: a graphical method for exploring dietary patterns

(2010) Raquel Canuto et al.   Cadernos de Saude Publica

The endocannabinoid system links gut microbiota to adipogenesis

(2010) Giulio G Muccioli et al.   Molecular Systems Biology

Biomarkers of Endocannabinoid System Activation in Severe Obesity

(2010) Jack C. Sipe et al.   PLoS One

Peroxisome Proliferator-Activated Receptor-α Control of Lipid and Glucose Metabolism in Human White Adipocytes

(2009) Carole Ribet et al.   ENDOCRINOLOGY

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects

(2009) Vincenzo Di Marzo et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Influence of assay-dependent variability of serum insulin levels on insulin sensitivity indices

(2008) Dana Borza et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors

(2008) V. Di Marzo et al.   DIABETOLOGIA

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Endocannabinoids, Adipose Tissue and Lipid Metabolism

(2008) C. Pagano et al.   JOURNAL OF NEUROENDOCRINOLOGY

The Endocannabinoid System and Energy Metabolism

(2008) L. Bellocchio et al.   JOURNAL OF NEUROENDOCRINOLOGY

Assay-dependent variability of serum insulin levels during oral glucose tolerance test: influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices

(2007) Maria Werner et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE