Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model

CX3CL1/CX3CR1-Mediated Microglia Activation Plays a Detrimental Role in Ischemic Mice Brain via p38MAPK/PKC Pathway

(2015) Yong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration

(2015) Kevin R Nash et al.   MOLECULAR THERAPY

Role of fractalkine–CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain

(2015) Idrish Ali et al.   NEUROBIOLOGY OF DISEASE

Excessive microglial activation aggravates olfactory dysfunction by impeding the survival of newborn neurons in the olfactory bulb of Niemann–Pick disease type C1 mice

(2014) Yoojin Seo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Plasma Signature of Neurological Disease in the Monogenetic Disorder Niemann-Pick Type C

(2014) Md. Suhail Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Donepezil Enhances Purkinje Cell Survival and Alleviates Motor Dysfunction by Inhibiting Cholesterol Synthesis in a Murine Model of Niemann Pick Disease Type C

(2014) Yoojin Seo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

(2014) Cristina Limatola et al.   Frontiers in Cellular Neuroscience

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

(2014) Rosa Chiara Paolicelli et al.   Frontiers in Cellular Neuroscience

Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

(2013) Urša Pečar Fonović et al.   BIOLOGICAL CHEMISTRY

Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation

(2013) J. A. Garcia et al.   JOURNAL OF IMMUNOLOGY

Cysteine Cathepsins in Neurological Disorders

(2013) Anja Pišlar et al.   MOLECULAR NEUROBIOLOGY

Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency

(2013) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Fractalkine mediates inflammatory pain through activation of satellite glial cells

(2013) G. R. Souza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

Altered Expression of CX3CL1 in Patients with Epilepsy and in a Rat Model

(2012) Yali Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Protect against Neuronal Cell Death and Ameliorate Motor Deficits in Niemann Pick Type C1 Mice

(2011) Yoojin Seo et al.   CELL TRANSPLANTATION

Microglial signalling mechanisms: Cathepsin S and Fractalkine

(2011) Anna K. Clark et al.   EXPERIMENTAL NEUROLOGY

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease

(2011) Mibel M Pabon et al.   Journal of Neuroinflammation

Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages

(2011) D. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

Brain cholesterol in normal and pathological aging

(2010) Mauricio Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Characterization of Synergistic Induction of CX3CL1/Fractalkine by TNF-  and IFN-  in Vascular Endothelial Cells: An Essential Role for TNF-  in Post-Transcriptional Regulation of CX3CL1

(2010) T. Matsumiya et al.   JOURNAL OF IMMUNOLOGY

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation

(2010) Qingyu Qin et al.   PLoS One

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

NEW evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease

(2009) Sun Shan et al.   NEUROBIOLOGY OF AGING

Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1

(2009) David Smith et al.   NEUROBIOLOGY OF DISEASE

Upregulation of cathepsin S in the aging and pathological nervous system of mice

(2008) Wiebke Wendt et al.   BRAIN RESEARCH

Impaired functions of neural stem cells by abnormal nitric oxide-mediated signaling in an in vitro model of Niemann-Pick type C disease

(2008) Sun-Jung Kim et al.   CELL RESEARCH

Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation

(2008) Patricia Hermand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

(2008) Ádám Dénes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM