Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity

Promotion of cancer cell stemness by Ras

(2021) Rohan Chippalkatti et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling

(2021) Farid Ahmad Siddiqui et al.   Cancers

Discovery and Optimization of Small Molecules Targeting the Protein–Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer

(2020) Lei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

(2019) Lei Wang et al.   Science Advances

Natural Occurrence, Bioactivity and Biosynthesis of Elaiophylin Analogues

(2019) Min Gui et al.   MOLECULES

Medium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay

(2019) Farid Ahmad Siddiqui et al.   SLAS Discovery

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

(2019) Farid A. Siddiqui et al.   ACS Omega

HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC

(2018) Jie Han et al.   Autophagy

Antiangiogenic Potential of Microbial Metabolite Elaiophylin for Targeting Tumor Angiogenesis

(2018) Haet Lim et al.   MOLECULES

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway

(2017) Takayuki Kimura et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1

(2017) Itziar M. D. Posada et al.   Scientific Reports

Cancer stem cell drugs target K-ras signaling in a stemness context

(2016) A K Najumudeen et al.   ONCOGENE

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering

(2016) Olga Blaževitš et al.   Scientific Reports

Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase

(2015) Yongjun Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin

(2015) Yongjun Zhou et al.   CHEMISTRY & BIOLOGY

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Maximizing the Therapeutic Potential of HSP90 Inhibitors

(2015) L. M. Butler et al.   MOLECULAR CANCER RESEARCH

Hsp90 regulates autophagy and plays a role in cancer therapy

(2015) Benli Wang et al.   TUMOR BIOLOGY

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation

(2014) Wei Huang et al.   Molecular Cancer

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Nonsteroidal Anti-inflammatory Drugs Alter the Spatiotemporal Organization of Ras Proteins on the Plasma Membrane

(2012) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Halichoblelides B and C, potent cytotoxic macrolides from a Streptomyces species separated from a marine fish

(2012) Takeshi Yamada et al.   TETRAHEDRON LETTERS

Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy

(2011) Joung Hyuck Joo et al.   MOLECULAR CELL

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

In vitro and in vivo antiprotozoal activities of bispolides and their derivatives

(2010) Kazuhiko Otoguro et al.   JOURNAL OF ANTIBIOTICS

Galectin-3 Promotes Chronic Activation of K-Ras and Differentiation Block in Malignant Thyroid Carcinomas

(2010) Ran Levy et al.   MOLECULAR CANCER THERAPEUTICS

Electrostatic Interactions Positively Regulate K-Ras Nanocluster Formation and Function

(2008) S. J. Plowman et al.   MOLECULAR AND CELLULAR BIOLOGY