Primary Amoebic Meningoencephalitis by Naegleria fowleri: Pathogenesis and Treatments

The type 2 statins, cerivastatin, rosuvastatin and pitavastatin eliminate Naegleria fowleri at low concentrations and by induction of programmed cell death (PCD)

(2021) Aitor Rizo-Liendo et al.   BIOORGANIC CHEMISTRY

Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae

(2020) Mohammad Ridwane Mungroo et al.   ACS Chemical Neuroscience

Activity of Auranofin against Multiple Genotypes of Naegleria fowleri and Its Synergistic Effect with Amphotericin B In Vitro

(2020) Jose Ignacio Escrig et al.   ACS Chemical Neuroscience

Epidemiology and Clinical Characteristics of Primary Amebic Meningoencephalitis Caused by Naegleria fowleri: A Global Review

(2020) Radhika Gharpure et al.   CLINICAL INFECTIOUS DISEASES

Identification of differential protein recognition pattern between Naegleria fowleri and Naegleria lovaniensis

(2020) Mara Gutiérrez‐Sánchez et al.   PARASITE IMMUNOLOGY

Battling brain-eating amoeba: Enigmas surrounding immunity to Naegleria fowleri

(2020) E. Ashley Moseman   PLoS Pathogens

Evaluation of Indolocarbazoles from Streptomyces sanyensis as a Novel Source of Therapeutic Agents against the Brain-Eating Amoeba Naegleria fowleri

(2020) Aitor Rizo-Liendo et al.   Microorganisms

Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae

(2020) Mohammad Ridwane Mungroo et al.   ACS Omega

Inhibition of Fatty Acid Oxidation as a New Target To Treat Primary Amoebic Meningoencephalitis

(2020) Maarten J. Sarink et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Azoles as Antiparasitic Remedies against Brain-Eating Amoebae

(2020) Ayaz Anwar et al.   Antibiotics-Basel

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri

(2020) Hye Jee Hahn et al.   ACS Chemical Neuroscience

Fluvastatin and atorvastatin induce programmed cell death in the brain eating amoeba Naegleria fowleri

(2020) Aitor Rizo-Liendo et al.   BIOMEDICINE & PHARMACOTHERAPY

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae

(2020) Christopher A. Rice et al.   PLoS Neglected Tropical Diseases

In Vitro Evaluation of Farnesyltransferase Inhibitor and its Effect in Combination with 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor against Naegleria fowleri

(2020) Hye Jee Hahn et al.   Pathogens

Isolation and Identification of Naegleria Species in Irrigation Channels for Recreational Use in Mexicali Valley, Mexico

(2020) Patricia Bonilla-Lemus et al.   Pathogens

Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids

(2019) Ayaz Anwar et al.   Scientific Reports

Enzymatic and structural characterization of the Naegleria fowleri glucokinase

(2019) Jillian E. Milanes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

trans-Cinnamic Acid Conjugated Gold Nanoparticles as Potent Therapeutics against Brain-Eating Amoeba Naegleria fowleri

(2019) Kavitha Rajendran et al.   ACS Chemical Neuroscience

Cellular characterization of actin gene concerned with contact‐dependent mechanisms in Naegleria fowleri

(2019) Hae‐Jin Sohn et al.   PARASITE IMMUNOLOGY

Oleic acid coated silver nanoparticles showed better in vitro amoebicidal effects against Naegleria fowleri than Amphotericin B

(2019) Kavitha Rajendran et al.   ACS Chemical Neuroscience

Naegleria fowleri

(2019) Jose E. Piñero et al.   TRENDS IN PARASITOLOGY

Killer amoebas

(2019) Amanda Marie Cooper et al.   JAAPA-Journal of the American Academy of Physician Assistants

In Vitro Activity of Statins against Naegleria fowleri

(2019) Aitor Rizo-Liendo et al.   Pathogens

Naegleria fowleri : Sources of infection, pathophysiology, diagnosis, and management; a review

(2019) Muhammad Jahangeer et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae Acanthamoeba castellanii and Naegleria fowleri

(2019) Areeba Anwar et al.   ACS Infectious Diseases

Acanthamoeba and its pathogenic role in granulomatous amebic encephalitis

(2019) Sonali K. Kalra et al.   EXPERIMENTAL PARASITOLOGY

Is Naegleria fowleri an Emerging Parasite?

(2019) Sutherland K. Maciver et al.   TRENDS IN PARASITOLOGY

Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri

(2018) Ingrid Zyserman et al.   EXPERIMENTAL PARASITOLOGY

The therapeutic strategies against Naegleria fowleri

(2018) Natália Karla Bellini et al.   EXPERIMENTAL PARASITOLOGY

An In Vitro Model of the Blood-Brain Barrier: Naegleria fowleri Affects the Tight Junction Proteins and Activates the Microvascular Endothelial Cells

(2018) Daniel Coronado-Velázquez et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

EFFECTS OF CULTURE MEDIA ON NAEGLERIA FOWLERI GROWTH AT DIFFERENT TEMPERATURES.

(2018) Silvere Dieudonne Zaongo et al.   JOURNAL OF PARASITOLOGY

Central Nervous System Infections

(2018) Richard A. Giovane et al.   PRIMARY CARE

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

(2018) Anjan Debnath et al.   Frontiers in Microbiology

The genome of Naegleria lovaniensis, the basis for a comparative approach to unravel pathogenicity factors of the human pathogenic amoeba N. fowleri

(2018) Nicole Liechti et al.   BMC GENOMICS

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

(2018) Wenxu Zhou et al.   PLoS Pathogens

Clinically Approved Drugs against CNS Diseases as Potential Therapeutic Agents To Target Brain-Eating Amoebae

(2018) Ayaz Anwar et al.   ACS Chemical Neuroscience

Phenotypic screens reveal posaconazole as rapidly cidal combination partner for treatment of Primary Amoebic Meningoencephalitis

(2018) Beatrice L Colon et al.   JOURNAL OF INFECTIOUS DISEASES

Production and characterization of monoclonal antibodies against cathepsin B and cathepsin B-Like proteins of Naegleria fowleri

(2017) Gi-Sang Seong et al.   EXPERIMENTAL PARASITOLOGY

Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome

(2017) Timothy Yu Yee Ong et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Efficient Liquid Media for Encystation of Pathogenic Free-Living Amoebae

(2017) Hae-Jin Sohn et al.   KOREAN JOURNAL OF PARASITOLOGY

Amphotericin B induces apoptosis-like programmed cell death in Naegleria fowleri and Naegleria gruberi

(2017) Roberto Cárdenas-Zúñiga et al.   MICROBIOLOGY-SGM

Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis

(2017) Melissa Jamerson et al.   MICROBIOLOGY-SGM

Expression of matrix metalloproteinases in Naegleria fowleri and their role in invasion of the central nervous system

(2017) Charlton Lam et al.   MICROBIOLOGY-SGM

Understanding host–parasite relationship: the immune central nervous system microenvironment and its effect on brain infections

(2017) Laura Adalid-Peralta et al.   PARASITOLOGY

Toll-like receptors participate in Naegleria fowleri recognition

(2017) Moisés Martínez-Castillo et al.   PARASITOLOGY RESEARCH

Surviving Naegleria fowleri infections: A successful case report and novel therapeutic approach

(2017) Travis W. Heggie et al.   Travel Medicine and Infectious Disease

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

(2017) Anjan Debnath et al.   PLoS Neglected Tropical Diseases

Naegleria fowleri: Diagnosis, Pathophysiology of Brain Inflammation, and Antimicrobial Treatments

(2016) J. Jeffrey Pugh et al.   ACS Chemical Neuroscience

Biology and pathogenesis of Naegleria fowleri

(2016) Ruqaiyyah Siddiqui et al.   ACTA TROPICA

NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri

(2016) Jong-Hyun Kim et al.   INFECTION AND IMMUNITY

Neutrophils extracellular traps damageNaegleria fowleritrophozoites opsonized with human IgG

(2016) A. Contis-Montes de Oca et al.   PARASITE IMMUNOLOGY

Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5 Years?

(2016) Jennifer R. Cope et al.   Current Infectious Disease Reports

Naegleria fowleri: Pathogenesis, Diagnosis, and Treatment Options

(2015) Eddie Grace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case: Table 1.

(2015) Jennifer R. Cope et al.   CLINICAL INFECTIOUS DISEASES

Lipid peroxidation in brain or spinal cord mitochondria after injury

(2015) Edward D. Hall et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Iron-Binding Protein Degradation by Cysteine Proteases ofNaegleria fowleri

(2015) Moisés Martínez-Castillo et al.   Biomed Research International

Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri

(2014) Denise C Zysset-Burri et al.   BMC GENOMICS

What do we know by now about the genus Naegleria?

(2014) Johan F. De Jonckheere   EXPERIMENTAL PARASITOLOGY

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

(2014) Hugo González et al.   Journal of Neuroinflammation

Vaccination with Lentiviral Vector Expressing thenfa1Gene Confers a Protective Immune Response to Mice Infected with Naegleria fowleri

(2013) Jong-Hyun Kim et al.   Clinical and Vaccine Immunology

Corifungin, a New Drug Lead against Naegleria, Identified from a High-Throughput Screen

(2012) Anjan Debnath et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pathogenic Naegleria fowleri and non-pathogenic Naegleria lovaniensis exhibit differential adhesion to, and invasion of, extracellular matrix proteins

(2012) M. Jamerson et al.   MICROBIOLOGY-SGM

IL-1β and IL-6 activate inflammatory responses of astrocytes against Naegleria fowleri infection via the modulation of MAPKs and AP-1

(2012) J.-H. Kim et al.   PARASITE IMMUNOLOGY

Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri

(2011) K.-J. SONG et al.   PARASITE IMMUNOLOGY

Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment*

(2010) Govinda S Visvesvara   CURRENT OPINION IN INFECTIOUS DISEASES

Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation

(2009) I. Cervantes-Sandoval et al.   MICROBIOLOGY-SGM

Effect of Therapeutic Chemical Agents In Vitro and on Experimental Meningoencephalitis Due to Naegleria fowleri

(2008) J.-H. Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic effect of rokitamycin in vitro and on experimental meningoencephalitis due to Naegleria fowleri

(2008) Jong-Hyun Kim et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Characterization of brain inflammation during primary amoebic meningoencephalitis

(2008) Isaac Cervantes-Sandoval et al.   PARASITOLOGY INTERNATIONAL

Heat shock protein 70 of Naegleria fowleri is important factor for proliferation and in vitro cytotoxicity

(2008) Kyoung-Ju Song et al.   PARASITOLOGY RESEARCH