Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

(2017) Anjan Debnath et al.   PLoS Neglected Tropical Diseases

Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts

(2017) Aabha I. Sharma et al.   Scientific Reports

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)

(2015) David C. Lamb et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Naegleria fowleri: Pathogenesis, Diagnosis, and Treatment Options

(2015) Eddie Grace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PotentIn VitroAntiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis

(2015) S. T. de Macedo-Silva et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case: Table 1.

(2015) Jennifer R. Cope et al.   CLINICAL INFECTIOUS DISEASES

Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri

(2014) Denise C Zysset-Burri et al.   BMC GENOMICS

Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory–secretory proteins and their biochemical properties

(2014) Jinyoung Lee et al.   PARASITOLOGY RESEARCH

Corifungin, a New Drug Lead against Naegleria, Identified from a High-Throughput Screen

(2012) Anjan Debnath et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IsoCor: correcting MS data in isotope labeling experiments

(2012) P. Millard et al.   BIOINFORMATICS

Sigma-1 Receptor Agonists as Therapeutic Drugs for Cognitive Impairment in Neuropsychiatric Diseases

(2012) Tomihisa Niitsu et al.   CURRENT PHARMACEUTICAL DESIGN

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Sink or swim: lipid rafts in parasite pathogenesis

(2012) Amanda M. Goldston et al.   TRENDS IN PARASITOLOGY

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity

(2011) Joshua Wollam et al.   AGING CELL

Novel sterol metabolic network ofTrypanosoma bruceiprocyclic and bloodstream forms

(2011) Craigen R. Nes et al.   BIOCHEMICAL JOURNAL

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

Origin and evolution of the worldwide distributed pathogenic amoeboflagellate Naegleria fowleri

(2011) Johan F. De Jonckheere   INFECTION GENETICS AND EVOLUTION

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature

(2009) Elie Desmond et al.   Genome Biology and Evolution

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS