COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity

Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

(2021) Kathryn A. Ryan et al.   Nature Communications

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

(2021) Jing-Hui Tian et al.   Nature Communications

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

(2021) Agnes Bonifacius et al.   IMMUNITY

Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

(2021) Jianmin Zuo et al.   NATURE IMMUNOLOGY

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

(2021) Joshua G. Liang et al.   Nature Communications

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials

(2021) Shilong Yang et al.   LANCET INFECTIOUS DISEASES

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

(2021) Prabhu S. Arunachalam et al.   NATURE

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

(2021) Chia-En Lien et al.   Scientific Reports

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Evaluation of Four Commercial Kits for SARS-CoV-2 Real-Time Reverse-Transcription Polymerase Chain Reaction Approved by Emergency-Use-Authorization in Korea

(2020) Kyu-Hwa Hur et al.   Frontiers in Medicine

Genomic evidence for reinfection with SARS-CoV-2: a case study

(2020) Richard L Tillett et al.   LANCET INFECTIOUS DISEASES

Animal models for COVID-19

(2020) César Muñoz-Fontela et al.   NATURE

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

(2020) Erik Volz et al.   CELL

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

(2020) Tsun-Yung Kuo et al.   Scientific Reports

Vaccination of special populations: Protecting the vulnerable

(2016) Mark Doherty et al.   VACCINE

Combination of TLR1/2 and TLR3 ligands enhances CD4+ T cell longevity and antibody responses by modulating type I IFN production

(2016) Bo Ryeong Lee et al.   Scientific Reports

Ferret models of viral pathogenesis

(2015) T. Enkirch et al.   VIROLOGY

Feasibility of utilizing the patellar ligament angle for assessing cranial cruciate ligament rupture in dogs

(2014) Jung-ha Lee et al.   Journal of Veterinary Science

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect

(2013) Samuele Calabro et al.   VACCINE

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

(2012) Nathalie Garçon et al.   Expert Review of Vaccines

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Use of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens and a Powerful Adjuvant To Develop an Immune Therapy for Chronic Hepatitis B Virus Infection

(2011) Jung Sun Yum et al.   Clinical and Vaccine Immunology

The immune responses of HLA-A*0201 restricted SARS-CoV S peptide-specific CD8+ T cells are augmented in varying degrees by CpG ODN, PolyI:C and R848

(2011) Kai Zhao et al.   VACCINE

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection

(2009) Karen Smith Korsholm et al.   IMMUNOLOGY

Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal  -Glucans and Toll-Like Receptor Agonists

(2009) H. Huang et al.   INFECTION AND IMMUNITY

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Different Immunization Protocols and Adjuvant on Antibody Responses to Inactivated SARS-CoV Vaccine

(2008) Weiwei Gai et al.   VIRAL IMMUNOLOGY