Autophagy and Mitochondrial Homeostasis During Infection: A Double-Edged Sword

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

(2021) Mohd Shariq et al.   Frontiers in Immunology

The Dual Regulation of Apoptosis by Flavivirus

(2021) Yuhong Pan et al.   Frontiers in Microbiology

Mitochondrial Functions in Infection and Immunity

(2020) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Overexpression of Toll-Like Receptor 4 Affects Autophagy, Oxidative Stress, and Inflammatory Responses in Monocytes of Transgenic Sheep

(2020) Sutian Wang et al.   Frontiers in Cell and Developmental Biology

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication

(2020) Chen Li et al.   Frontiers in Microbiology

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging

(2020) Megumi Inomata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Cell Death Responses to Non-typhoidal Salmonella Infection

(2019) Madeleine A. Wemyss et al.   Frontiers in Immunology

The ICP0 protein of herpes simplex virus 1 (HSV-1) down-regulates major autophagy adaptor proteins, sequestosome 1 (SQSTM1/p62) and optineurin (OPTN), during the early stages of HSV-1 infection.

(2019) Hope Waisner et al.   JOURNAL OF VIROLOGY

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

(2019) Renan V. H. de Carvalho et al.   Nature Communications

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

(2018) Soh Yamamoto et al.   Cell Reports

Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury

(2018) Mingxia Zhou et al.   EBioMedicine

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

(2018) Isaac Tamargo-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy benefits the replication of influenza A virus in vitro

(2018) Ruifang Wang et al.   JOURNAL OF VIROLOGY

Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2 sensing

(2018) Brandán Pedre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction

(2017) Ting Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

(2016) Laurent Chatel-Chaix et al.   Cell Host & Microbe

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus

(2016) Xiaojing Li et al.   Cell Death & Disease

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

(2016) Nari Kim et al.   Nature Communications

Mitochondrial damage contributes toPseudomonas aeruginosaactivation of the inflammasome and is downregulated by autophagy

(2015) Majid Sakhi Jabir et al.   Autophagy

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

(2015) Serge Ducommun et al.   CELLULAR SIGNALLING

Macrophage defense mechanisms against intracellular bacteria

(2015) Günter Weiss et al.   IMMUNOLOGICAL REVIEWS

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation

(2015) B. Ma et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

(2015) Yue Wu et al.   NATURE MEDICINE

Superoxide dismutase of Streptococcus suis serotype 2 plays a role in anti-autophagic response by scavenging reactive oxygen species in infected macrophages

(2015) Lihua Fang et al.   VETERINARY MICROBIOLOGY

Streptococcus pneumoniae Induces Autophagy through the Inhibition of the PI3K-I/Akt/mTOR Pathway and ROS Hypergeneration in A549 Cells

(2015) Pu Li et al.   PLoS One

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons

(2012) Tal Kramer et al.   Cell Host & Microbe

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

(2012) C. He et al.   DIABETES

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

cAMP and EPAC Are Key Players in the Regulation of the Signal Transduction Pathway Involved in the α-Hemolysin Autophagic Response

(2012) María Belén Mestre et al.   PLoS Pathogens

Selective autophagy and viruses

(2011) Rhea Sumpter et al.   Autophagy

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Differential Regulation of the PGC Family of Genes in a Mouse Model of Staphylococcus aureus Sepsis

(2010) Timothy E. Sweeney et al.   PLoS One

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

LPS induces inflammatory responses in human aortic vascular smooth muscle cells via Toll-like receptor 4 expression and nitric oxide production

(2008) S HEO et al.   IMMUNOLOGY LETTERS

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

(2008) Chong-Shan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL