Potent therapeutic targets for treatment of Alzheimer's disease: Amyloid degrading enzymes

Redox-Active Metal Ions and Amyloid-Degrading Enzymes in Alzheimer’s Disease

(2021) Namdoo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure and Function of Human Matrix Metalloproteinases

(2020) Helena Laronha et al.   Cells

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Vitamin D Inhibits Activities of Metalloproteinase-9/-13 in Articular Cartilage In Vivo and In Vitro

(2019) Siwei LI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Crystal structure of peptide‐bound neprilysin reveals key binding interactions

(2019) Stephen Moss et al.   FEBS LETTERS

Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer’s Disease

(2018) Anna Więckowska et al.   ACS Chemical Neuroscience

Augmentation of glucagon-like peptide-1 receptor signalling by neprilysin inhibition: potential implications for patients with heart failure

(2018) Milton Packer   EUROPEAN JOURNAL OF HEART FAILURE

Interplay between Copper, Neprilysin, and N-Truncation of β-Amyloid

(2018) Mariusz Mital et al.   INORGANIC CHEMISTRY

Memantine protects against ischemia/reperfusion-induced brain endothelial permeability

(2018) Yingying Liu et al.   IUBMB LIFE

The Effect of Chronic Cerebral Hypoperfusion on Amyloid-β Metabolism in a Transgenic Mouse Model of Alzheimer’s Disease (PS1V97L)

(2018) Heyun Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes

(2018) Marta Martínez-Bonet et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High resolution crystal structure of substrate-free human neprilysin

(2018) Stephen Moss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Application of Ferulic Acid for Alzheimer’s Disease: Combination of Text Mining and Experimental Validation

(2018) Guilin Meng et al.   Frontiers in Neuroinformatics

Topical folinic acid enhances wound healing in rat model

(2018) Nilay Duman et al.   Advances in Medical Sciences

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Investigation of Matrix Metalloproteinases, MMP-2 and MMP-9, in Plasma Reveals a Decrease of MMP-2 in Alzheimer's Disease

(2018) Nastasia K.-H. Lim et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease

(2018) Amanda J. Stock et al.   Journal of Neuroinflammation

Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1–42

(2018) Gu-Ran Yu et al.   Neural Regeneration Research

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

(2018) Christian Klein et al.   Acta Neuropathologica Communications

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

(2017) Marcus Grimm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cognitive Decline in Preclinical Alzheimer’s Disease: Amyloid-Beta versus Tauopathy

(2017) Colin M. Huber et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Vitamin C, Aging and Alzheimer’s Disease

(2017) et al.   Nutrients

Old and new acetylcholinesterase inhibitors for Alzheimer’s disease

(2016) Daniela Galimberti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The neprilysin pathway in heart failure: a review and guide on the use of sacubitril/valsartan

(2016) Pardeep S Jhund et al.   HEART

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-  Alterations in a Monkey Model of Type 1 Diabetes

(2016) J. Morales-Corraliza et al.   JOURNAL OF NEUROSCIENCE

A Test in Context: Neprilysin

(2016) Antoni Bayes-Genis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

(2015) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Neprilysin Is Predictive of Cardiovascular Death and Heart Failure Hospitalization in Heart Failure Patients

(2015) Antoni Bayés-Genís et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A combination Alzheimer’s therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice

(2015) Latha Devi et al.   Molecular Brain

Mercury-induced amyloid-beta (Aβ) accumulation in the brain is mediated by disruption of Aβ transport

(2014) Dong-Kyeong Kim et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

(2013) Maria B. Goncalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells

(2013) S. K. Halder et al.   HUMAN REPRODUCTION

Green tea catechin leads to global improvement among Alzheimer's disease-related phenotypes in NSE/hAPP-C105 Tg mice

(2013) Hwa Ja Lim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impact of Vitamin D on Amyloid Precursor Protein Processing and Amyloid-β Peptide Degradation in Alzheimer's Disease

(2013) Marcus O.W. Grimm et al.   Neurodegenerative Diseases

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

(2013) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

(2012) Sang-Sun Yoon et al.   Biomolecules & Therapeutics

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1

(2012) Lisa A. Ridnour et al.   JOURNAL OF NEUROCHEMISTRY

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

(2011) H. Rheinallt Parri et al.   BIOCHEMICAL PHARMACOLOGY

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease

(2010) Solveig Horstmann et al.   INTERNATIONAL PSYCHOGERIATRICS

Vitamin A Upregulates Matrix Metalloproteinase-9 Activity by Murine Myeloid Dendritic Cells through a Nonclassical Transcriptional Mechanism

(2010) Denise E. Lackey et al.   JOURNAL OF NUTRITION

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Alteration of Aβ metabolism-related molecules in predementia induced by AlCl3 and d-galactose

(2009) Zong-Zheng Sun et al.   AGE

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation

(2009) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloprotease-9 Inhibition Improves Amyloid  -Mediated Cognitive Impairment and Neurotoxicity in Mice

(2009) H. Mizoguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis

(2009) M. Hasan Mohajeri et al.   NEUROCHEMICAL RESEARCH

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging

(2008) Emily L. Que et al.   CHEMICAL REVIEWS

Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease

(2008) Natalia Nalivaeva et al.   Current Alzheimer Research

Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Aβ levels

(2006) E. Hellström-Lindahl et al.   NEUROBIOLOGY OF AGING