Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Guaianolide Sesquiterpene Lactones from Centaurothamnus maximus

(2021) Taha A. Hussien et al.   MOLECULES

The Possible Anti-Inflammatory Effect of Dehydrocostus Lactone on DSS-Induced Colitis in Mice

(2020) Qing Zhou et al.   Evidence-based Complementary and Alternative Medicine

Human Gut Microbiota Metabolism of Dietary Sesquiterpene Lactones: Untargeted Metabolomics Study of Lactucopicrin and Lactucin Conversion In Vitro and In Vivo

(2020) Carlos J. García et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans

(2020) Hui Weng et al.   Nutrients

Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

(2020) Melanie S. Matos et al.   Nutrients

Costunolide inhibits matrix metalloproteinases expression and osteoarthritis via the NF‑κB and Wnt/β‑catenin signaling pathways

(2019) Yuzhe He et al.   Molecular Medicine Reports

Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile

(2019) Mounira Benteldjoune et al.   PLANTA MEDICA

Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin

(2019) Mohammed N. A. Khalil et al.   PLoS One

Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A mini-review

(2019) Jiangming Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway

(2019) Yijing Ren et al.   Scientific Reports

Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2

(2019) Lanlan Pan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppressive effects of dehydrocostus lactone on the toll-like receptor signaling pathways

(2019) Su Yeon Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

(2019) R. Sabel et al.   JOURNAL OF ETHNOPHARMACOLOGY

Costunolide suppresses an inflammatory angiogenic response in a subcutaneous murine sponge model

(2018) Sarita Saraswati et al.   APMIS

Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors

(2018) Adriana Coricello et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Five rare C 32 sesquiterpene lactone dimers with anti-inflammation activity from Vladimiria souliei

(2018) Zhi-li Wu et al.   FITOTERAPIA

Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

(2018) Jiang-Jiang Tang et al.   Scientific Reports

Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

(2018) Victor Fattori et al.   Frontiers in Pharmacology

Anti-inflammatory sesquiterpene lactones from Onopordum illyricum L. (Asteraceae), an Italian medicinal plant

(2017) Carmen Formisano et al.   FITOTERAPIA

The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

(2017) Ana C. Zarpelon et al.   INFLAMMATION

Anti-inflammatory and antioxidant potential of Guaianolide isolated from Cyathocline purpurea : Role of COX-2 inhibition

(2017) Urmila U. Tambewagh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis

(2017) Shuang Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues

(2017) Siwattra Choodej et al.   PLANTA MEDICA

Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types

(2017) Paula Zwicker et al.   TOXICOLOGY IN VITRO

Micheliolide suppresses LPS-induced neuroinflammatory responses

(2017) Zhaomeng Sun et al.   PLoS One

Sesquiterpene Lactones: More Than Protective Plant Compounds With High Toxicity

(2016) Guillermo Federico Padilla-Gonzalez et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Chemical modification of arglabin and biological activity of its new derivatives

(2016) S.M. Adekenov   FITOTERAPIA

Artemisinin inhibits monocyte adhesion to HUVECs through the NF-κB and MAPK pathways in vitro

(2016) YUE WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Unusual sesquiterpenes from Centaurea athoa DC

(2016) Serdar Demir et al.   Phytochemistry Letters

Micheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge

(2016) Xiangyang Qin et al.   Scientific Reports

Parthenolide inhibits LPS-induced inflammatory cytokines through the toll-like receptor 4 signal pathway in THP-1 cells

(2015) S. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet

(2015) A. Abderrazak et al.   CIRCULATION

Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone fromCota palaestinasubsp.syriaca

(2015) Rabih S. Talhouk et al.   Evidence-based Complementary and Alternative Medicine

Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of Radix Inulae Extract

(2015) Renjie Xu et al.   MOLECULES

Localization of sesquiterpene lactone biosynthesis in cells of capitate glandular trichomes of Helianthus annuus (Asteraceae)

(2015) Evelyn Amrehn et al.   PROTOPLASMA

A Sesquiterpene Lactone from a Medicinal Herb Inhibits Proinflammatory Activity of TNF-α by Inhibiting Ubiquitin-Conjugating Enzyme UbcH5

(2014) Li Liu et al.   CHEMISTRY & BIOLOGY

Inhibitory Effects of JEUD-38, a New Sesquiterpene Lactone from Inula japonica Thunb, on LPS-Induced iNOS Expression in RAW264.7 Cells

(2014) Xiaoqing Wang et al.   INFLAMMATION

Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

(2014) Emilie Viennois et al.   LABORATORY INVESTIGATION

Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis

(2014) HUA XU et al.   Molecular Medicine Reports

Bioactivity screening of fiveCentaureaspecies andin vivoanti-inflammatory activity ofC. athoa

(2014) Sura Baykan Erel et al.   PHARMACEUTICAL BIOLOGY

Inhibition of Inflammatory and Proliferative Responses of Human Keratinocytes Exposed to the Sesquiterpene Lactones Dehydrocostuslactone and Costunolide

(2014) Claudia Scarponi et al.   PLoS One

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging

(2013) Adriana A. Lopes et al.   CHEMICAL COMMUNICATIONS

Modulation of COX, LOX and NFκB activities by Xanthium spinosum L. root extract and ziniolide

(2013) Ammar Bader et al.   FITOTERAPIA

Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages

(2013) Hyung Gyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Sesquiterpenoids Lactones: Benefits to Plants and People

(2013) Martin Chadwick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model

(2013) Ana Beatriz Albino de Almeida et al.   JOURNAL OF ETHNOPHARMACOLOGY

Biosynthesis of Sesquiterpene Lactones in Pyrethrum (Tanacetum cinerariifolium)

(2013) Aldana M. Ramirez et al.   PLoS One

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

(2012) Chuan Bian Lim et al.   BMC Complementary and Alternative Medicine

Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells

(2012) Hyun-Gyu Choi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells

(2012) Jaemoo Chun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis

(2012) Chi-Chang Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Parthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-α and NF-κB Nuclear Translocation in BV-2 Microglia

(2012) Paolo Magni et al.   PHYTOTHERAPY RESEARCH

Anti-Inflammatory Sesquiterpene Lactones fromLychnophora trichocarphaSpreng. (Brazilian Arnica)

(2012) Fernanda C. Ferrari et al.   PHYTOTHERAPY RESEARCH

Perspectives on Sesquiterpene Lactones in Inflammation and Cancer

(2011) Irmgard Merfort   CURRENT DRUG TARGETS

Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats

(2011) Christoph Rummel et al.   CYTOKINE

NF-κB-mediated anti-inflammatory activity of the sesquiterpene lactone 7-hydroxyfrullanolide

(2011) Lyle C. Fonseca et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines

(2011) Mareike Maas et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes

(2011) Laryssa K. Rauh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.)

(2011) Mohammad Majdi et al.   PHYTOCHEMISTRY

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

(2011) Elena Butturini et al.   PLoS One

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

7-hydroxyfrullanolide, a sesquiterpene lactone, inhibits pro-inflammatory cytokine production from immune cells and is orally efficacious in animal models of inflammation

(2010) Lyle C. Fonseca et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6

(2010) Jongkyu Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sesquiterpene lactone fraction fromArtemisia khorassanicainhibits inducible nitric oxide synthase and cyclooxygenase-2 expression through the inactivation of NF-κB

(2010) Seyyed Ahmad Emami et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Recent developments in anti-inflammatory natural products

(2009) Raju Gautam et al.   MEDICINAL RESEARCH REVIEWS

Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms

(2009) Carsten Berges et al.   MOLECULAR IMMUNOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE