ChoK-Full of Potential: Choline Kinase in B Cell and T Cell Malignancies

PET/CT in Multiple Myeloma: Beyond FDG

(2021) Federica Matteucci et al.   Frontiers in Oncology

18 F‐choline radiotracer positron emission tomography as a new means to monitor central nervous system lymphoma

(2021) Thomas Millard et al.   BRITISH JOURNAL OF HAEMATOLOGY

Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration

(2020) Mounia Beloueche-Babari et al.   BRITISH JOURNAL OF CANCER

Choline PET/CT in Multiple Myeloma

(2020) Charles Mesguich et al.   Cancers

Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition

(2020) Belén Rubio‐Ruiz et al.   MEDICINAL RESEARCH REVIEWS

Therapeutic potential of PI3K signaling in distinct entities of B-cell lymphoma

(2019) Ramona Wullenkord et al.   Expert Review of Hematology

Elevated Choline Kinase α–Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes

(2019) Samantha Gokhale et al.   JOURNAL OF IMMUNOLOGY

EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells

(2018) Elena Mariotto et al.   BIOCHEMICAL PHARMACOLOGY

Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway

(2018) Benet Pera et al.   EBioMedicine

Genetic Alterations of TRAF Proteins in Human Cancers

(2018) Sining Zhu et al.   Frontiers in Immunology

18F-Choline and 18F-FDG PET/CT in a Patient With Diffuse Large B-Cell Lymphoma and Recurrent Prostate Cancer

(2018) Nicolas De Leiris et al.   CLINICAL NUCLEAR MEDICINE

From yeast to humans - roles of the Kennedy pathway for phosphatidylcholine synthesis

(2017) Christopher R. McMaster   FEBS LETTERS

Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression

(2017) Xi-Meng Lin et al.   GASTROENTEROLOGY

Targeting personalized medicine in a non-Hodgkin lymphoma patient with 18F-FDG and 18F-choline PET/CT

(2017) Thalles H. Ribeiro et al.   Revista da Associacao Medica Brasileira

MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma

(2017) J Xiong et al.   Blood Cancer Journal

Serum Metabolomics of Burkitt Lymphoma Mouse Models

(2017) Fengmin Yang et al.   PLoS One

B-cell survival and development controlled by the coordination of NF- B family members RelB and cRel

(2016) J. V. Almaden et al.   BLOOD

Phosphatidylcholine as a metabolic cue for determining B cell fate and function

(2016) Joseph W. Brewer et al.   CELLULAR IMMUNOLOGY

Biochemical and Pathophysiological Premises to Positron Emission Tomography With Choline Radiotracers

(2016) Vincenzo Cuccurullo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells

(2016) Nilushi S. De Silva et al.   JOURNAL OF IMMUNOLOGY

Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer

(2016) Yi Kong et al.   ONCOLOGY REPORTS

Choline kinase alpha—Putting the ChoK-hold on tumor metabolism

(2016) Sean P. Arlauckas et al.   PROGRESS IN LIPID RESEARCH

Serum metabonomics of acute leukemia using nuclear magnetic resonance spectroscopy

(2016) Syed Ghulam Musharraf et al.   Scientific Reports

Targeting Phospholipid Metabolism in Cancer

(2016) Menglin Cheng et al.   Frontiers in Oncology

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

(2016) Santiago Schiaffino-Ortega et al.   Scientific Reports

Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer

(2015) Takashi Uehara et al.   ANNALS OF SURGICAL ONCOLOGY

Incidental Detection of a Hodgkin Lymphoma on 18F-Choline PET/CT and Comparison With 18F-FDG in a Patient With Prostate Cancer

(2015) Aurore Goineau et al.   CLINICAL NUCLEAR MEDICINE

Choline metabolism-based molecular diagnosis of cancer: an update

(2015) Kristine Glunde et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1

(2015) Francisco Fermín Castro-Navas et al.   Future Medicinal Chemistry

Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma

(2015) Fumiyuki Yamasaki et al.   JOURNAL OF NEUROSURGERY

Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival

(2015) Noriko Mori et al.   NMR IN BIOMEDICINE

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence

(2015) Eman Abdelzaher et al.   TUMOR BIOLOGY

Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting

(2015) J Xiong et al.   Blood Cancer Journal

Choline kinase alpha expression during RA-induced neuronal differentiation: Role of C/EBPβ

(2014) Pablo Domizi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Targeting PI3-kinase (PI3K), AKT and mTOR axis in lymphoma

(2014) James S. Blachly et al.   BRITISH JOURNAL OF HAEMATOLOGY

Status of PI3K/Akt/mTOR Pathway Inhibitors in Lymphoma

(2014) Jason R. Westin   Clinical Lymphoma Myeloma & Leukemia

Incidental Diagnosis of Diffuse Large B-Cell Lymphoma by 11C-Choline PET/CT in a Patient With Biochemical Recurrence of Prostate Cancer

(2014) JR Garcia Garzon et al.   CLINICAL NUCLEAR MEDICINE

Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits

(2014) Nicole Heise et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of putative target genes for amplification within 11q13.2 and 3q27.1 in esophageal squamous cell carcinoma

(2013) Z.-Z. Shi et al.   Clinical & Translational Oncology

Megaconial congenital muscular dystrophy due to loss-of-function mutations in choline kinase β

(2013) Satomi Mitsuhashi et al.   CURRENT OPINION IN NEUROLOGY

High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers

(2013) Katharina Grupp et al.   Molecular Oncology

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function

(2013) Sruti Krishna et al.   Frontiers in Immunology

Balance of human choline kinase isoforms is critical for cell cycle regulation

(2012) Jens Gruber et al.   FEBS Journal

Histone Deacetylase Inhibition Increases Levels of Choline Kinase   and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

(2011) M. Beloueche-Babari et al.   CANCER RESEARCH

Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia

(2011) Aditya Bansal et al.   JOURNAL OF LIPID RESEARCH

Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice

(2011) C R Moore et al.   LEUKEMIA

Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells

(2011) Judy S. Su et al.   NMR IN BIOMEDICINE

Choline kinase and its functionThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

(2010) Gengshu Wu et al.   Biochemistry and Cell Biology

Early detection of radiation therapy response in non-Hodgkin's lymphoma xenografts by in vivo1H magnetic resonance spectroscopy and imaging

(2010) Seung-Cheol Lee et al.   NMR IN BIOMEDICINE

Identification of Key Regions and Genes Important in the Pathogenesis of Sezary Syndrome by Combining Genomic and Expression Microarrays

(2009) E. Caprini et al.   CANCER RESEARCH

CTP:Phosphocholine Cytidylyltransferase α Is Required for B-cell Proliferation and Class Switch Recombination

(2009) Paolo Fagone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Nervous System Lymphoma Characterization by Diffusion-Weighted Imaging and MR Spectroscopy

(2009) T. Thomas Zacharia et al.   JOURNAL OF NEUROIMAGING

Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma

(2009) S Eckerle et al.   LEUKEMIA

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Proliferation Markers for the Differential Diagnosis of Tumor and Inflammation

(2008) Aren Waarde et al.   CURRENT PHARMACEUTICAL DESIGN

Roles of TRAF molecules in B lymphocyte function

(2008) Ping Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

Expression and function of fatty acid amide hydrolase in prostate cancer

(2008) Michael P. Endsley et al.   INTERNATIONAL JOURNAL OF CANCER

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis

(2008) Verena Brune et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivoMRS markers of response to CHOP chemotherapy in the WSU-DLCL2 human diffuse large B-cell lymphoma xenograft

(2008) Seung-Cheol Lee et al.   NMR IN BIOMEDICINE

In vivo1H MRS of WSU-DLCL2 human non-Hodgkin's lymphoma xenografts: response to rituximab and rituximab plus CHOP

(2008) Seung-Cheol Lee et al.   NMR IN BIOMEDICINE