Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

Choline Kinase Active Site Provides Features for Designing Versatile Inhibitors

(2015) L. Serran-Aguilera et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1

(2015) Francisco Fermín Castro-Navas et al.   Future Medicinal Chemistry

Targeting cancer with kinase inhibitors

(2015) Stefan Gross et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1

(2015) Lucía Serrán-Aguilera et al.   Molecular Informatics

Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting

(2015) J Xiong et al.   Blood Cancer Journal

Discovery of a New Binding Site on Human Choline Kinase α1: Design, Synthesis, Crystallographic Studies, and Biological Evaluation of Asymmetrical Bispyridinium Derivatives

(2014) Belén Rubio-Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Characterization of RSM-932A, a Novel Anticancer Drug Targeting the Human Choline Kinase Alpha, an Enzyme Involved in Increased Lipid Metabolism of Cancer Cells

(2014) J. C. Lacal et al.   MOLECULAR CANCER THERAPEUTICS

The Mechanism of Allosteric Coupling in Choline Kinase α1 Revealed by the Action of a Rationally Designed Inhibitor

(2013) María Sahún-Roncero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis

(2013) Elena Porcù et al.   ANGIOGENESIS

New non-symmetrical choline kinase inhibitors

(2013) Santiago Schiaffino-Ortega et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer

(2013) A Granata et al.   BRITISH JOURNAL OF CANCER

Determination of Potential Scaffolds for Human Choline Kinase α1 by Chemical Deconvolution Studies

(2013) María Sahún-Roncero et al.   CHEMBIOCHEM

Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

(2013) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors

(2013) Sebastian Trousil et al.   MedChemComm

The mutational landscape of phosphorylation signaling in cancer

(2013) Jüri Reimand et al.   Scientific Reports

Novel 4-Amino Bis-pyridinium and Bis-quinolinium Derivatives as Choline Kinase Inhibitors with Antiproliferative Activity against the Human Breast Cancer SKBR-3 Cell Line

(2012) Verónica Gómez-Pérez et al.   ChemMedChem

Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors

(2012) Belén Rubio-Ruíz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Balance of human choline kinase isoforms is critical for cell cycle regulation

(2012) Jens Gruber et al.   FEBS Journal

Protein kinase signaling networks in cancer

(2010) John Brognard et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT