Cell Replacement Therapy for Retinal and Optic Nerve Diseases: Cell Sources, Clinical Trials and Challenges

Stem cell therapies for retinal diseases: from bench to bedside

(2020) Yuening Shen   JOURNAL OF MOLECULAR MEDICINE-JMM

Human Mesenchymal Stem Cell Secretome Exhibits a Neuroprotective Effect over In Vitro Retinal Photoreceptor Degeneration

(2020) Ricardo Usategui-Martín et al.   Molecular Therapy-Methods & Clinical Development

Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis

(2020) Oliver W. Gramlich et al.   Translational Vision Science & Technology

HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration

(2020) Sunao Sugita et al.   Journal of Clinical Medicine

Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials

(2020) Yiqi Wang et al.   Cell Death & Disease

Stem‐cell‐based therapies for retinal degenerative diseases: Current challenges in the establishment of new treatment strategies

(2020) Hirofumi Uyama et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures

(2019) Sonia Labrador-Velandia et al.   EXPERIMENTAL EYE RESEARCH

Long-term neuronal survival, regeneration, and transient target reconnection after optic nerve crush and mesenchymal stem cell transplantation

(2019) Louise A. Mesentier-Louro et al.   Stem Cell Research & Therapy

Effects of a combinatorial treatment with gene and cell therapy on retinal ganglion cell survival and axonal outgrowth after optic nerve injury

(2019) Gabriel Nascimento-dos-Santos et al.   GENE THERAPY

Current Stem-Cell Approaches for the Treatment of Inherited Retinal Degenerations

(2019) David Terrell et al.   Seminars in Ophthalmology

Restoration of visual function by transplantation of optogenetically engineered photoreceptors

(2019) Marcela Garita-Hernandez et al.   Nature Communications

Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications

(2019) Lin Fu et al.   Biomed Research International

Intravitreal injection of mesenchymal stem cells evokes retinal vascular damage in rats

(2019) Hongpeng Huang et al.   FASEB JOURNAL

Gene therapy in optic nerve disease

(2018) Adam DeBusk et al.   CURRENT OPINION IN OPHTHALMOLOGY

Therapeutic avenues for hereditary forms of retinal blindness

(2018) Chitra Kannabiran et al.   JOURNAL OF GENETICS

A drug-tunable gene therapy for broad-spectrum protection against retinal degeneration

(2018) Clayton P. Santiago et al.   MOLECULAR THERAPY

Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

(2018) Lyndon da Cruz et al.   NATURE BIOTECHNOLOGY

Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration

(2018) Manjit S. Mehat et al.   OPHTHALMOLOGY

3D Microstructured Scaffolds to Support Photoreceptor Polarization and Maturation

(2018) Yei Hwan Jung et al.   ADVANCED MATERIALS

Efficacy and Safety of Autologous Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with Diabetic Retinopathy

(2018) Xianliang Gu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Application of CRISPR/Cas9 technologies combined with iPSCs in the study and treatment of retinal degenerative diseases

(2018) Bincui Cai et al.   HUMAN GENETICS

Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration

(2018) Yong Liu et al.   Cell Discovery

Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits

(2017) Sonia Labrador Velandia et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Progress of stem/progenitor cell-based therapy for retinal degeneration

(2017) Zhimin Tang et al.   Journal of Translational Medicine

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Retinal regeneration mechanisms linked to multiple cancer molecules: A therapeutic conundrum

(2017) Amanda Barber et al.   PROGRESS IN RETINAL AND EYE RESEARCH

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Regenerating optic pathways from the eye to the brain

(2017) Bireswar Laha et al.   SCIENCE

A Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors

(2017) Arturo Ortin-Martinez et al.   STEM CELLS

Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions

(2017) Sacha Reichman et al.   STEM CELLS

Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms

(2017) Ben Mead et al.   Stem Cells Translational Medicine

Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies

(2016) M.I.G. Lopez Sanchez et al.   PHARMACOLOGY & THERAPEUTICS

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

(2016) Sunao Sugita et al.   Stem Cell Reports

Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials

(2016) Sonia Labrador-Velandia et al.   World Journal of Stem Cells

Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells

(2016) Alexander G. Bassuk et al.   Scientific Reports

Personalized therapeutic strategies for patients with retinitis pigmentosa

(2015) Andrew Zheng et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Retinal pigment epithelium transplantation: concepts, challenges and future prospects

(2015) P Alexander et al.   EYE

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

(2015) Steven D Schwartz et al.   LANCET

Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice

(2015) Yumi Ueki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial)

(2015) Rubens C Siqueira et al.   Stem Cell Research & Therapy

Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients

(2015) Won Kyung Song et al.   Stem Cell Reports

Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells

(2015) Taku Tanaka et al.   Scientific Reports

Diagnosis and classification of neuromyelitis optica (Devic's Syndrome)

(2014) Tali Drori et al.   AUTOIMMUNITY REVIEWS

Stem Cell Therapies in the Management of Diabetic Retinopathy

(2014) Roly Megaw et al.   Current Diabetes Reports

CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype

(2014) E R Burnight et al.   GENE THERAPY

Intravitreal Autologous Bone Marrow CD34+ Cell Therapy for Ischemic and Degenerative Retinal Disorders: Preliminary Phase 1 Clinical Trial Findings

(2014) S. S. Park et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells

(2014) Nutan Prasain et al.   NATURE BIOTECHNOLOGY

Gene Therapy Using Stem Cells

(2014) E. R. Burnight et al.   Cold Spring Harbor Perspectives in Medicine

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

(2014) Hiroyuki Kamao et al.   Stem Cell Reports

Proof of concept for AAV2/5-mediated gene therapy in iPSC-derived retinal pigment epithelium of a choroideremia patient

(2014) Nicolas Cereso et al.   Molecular Therapy-Methods & Clinical Development

Randomized Trial of Ciliary Neurotrophic Factor Delivered by Encapsulated Cell Intraocular Implants for Retinitis Pigmentosa

(2013) David G. Birch et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Vascular Progenitors From Cord Blood–Derived Induced Pluripotent Stem Cells Possess Augmented Capacity for Regenerating Ischemic Retinal Vasculature

(2013) Tea Soon Park et al.   CIRCULATION

Retinal Pigmented Epithelial Cells Obtained from Human Induced Pluripotent Stem Cells Possess Functional Visual Cycle Enzymesin Vitroandin Vivo

(2013) Tadao Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

(2013) Ryoko Araki et al.   NATURE

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

(2013) Anai Gonzalez-Cordero et al.   NATURE BIOTECHNOLOGY

Correction: Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy

(2013) Thomas A. Mendel et al.   PLoS One

Enhancing the Function of CD34+ Cells by Targeting Plasminogen Activator Inhibitor-1

(2013) Sugata Hazra et al.   PLoS One

Developing Rods Transplanted into the Degenerating Retina of Crx-Knockout Mice Exhibit Neural Activity Similar to Native Photoreceptors

(2013) Kohei Homma et al.   STEM CELLS

Adult Human RPE Can Be Activated into a Multipotent Stem Cell that Produces Mesenchymal Derivatives

(2012) Enrique Salero et al.   Cell Stem Cell

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Emerging Therapy for Diabetic Neuropathy: Cell Therapy Targeting Vessels and Nerves

(2012) Hyongbum Kim et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

A Free Retinal Pigment Epithelium–Choroid Graft in Patients With Exudative Age-Related Macular Degeneration: Results up to 7 Years

(2011) Elsbeth J.T. van Zeeburg et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Retinitis Pigmentosa: Genes and Disease Mechanisms

(2011) Francesco Parmeggiani et al.   CURRENT GENOMICS

Protective effects of human umbilical cord blood stem cell intravitreal transplantation against optic nerve injury in rats

(2011) Tantai Zhao et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

(2011) Budd A. Tucker et al.   PLoS One

Four Steps to Optic Nerve Regeneration

(2010) Darcie L Moore et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice

(2009) Deepak A. Lamba et al.   Cell Stem Cell

Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats

(2008) Paula Castanheira et al.   ARQUIVOS BRASILEIROS DE OFTALMOLOGIA