Article
Ophthalmology
Simone Tzaridis, Tjebo Heeren, Clarissa Mai, Sarah Thiele, Frank G. Holz, Peter Charbel Issa, Philipp Herrmann
Summary: This study evaluated the role of right-angled vessels (RAVs) in disease progression in macular telangiectasia type 2 (MacTel). RAVs were detected early in the disease stages and shown to form connections to neovascular complexes, indicating their involvement in the development of secondary neovascularizations in MacTel.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Noam D. Rudnick, Filippos Vingopoulos, Jay C. Wang, Itika Garg, Ying Cui, Ying Zhu, Rongrong Le, Raviv Katz, Yifan Lu, Nimesh A. Patel, John B. Miller
Summary: This study used widefield swept-source optical coherence tomography angiography (WF SS OCTA) to characterize the morphology, location, and functional significance of macular and extramacular collateral vessels (CVs) in patients with a history of branch retinal vein occlusion (BRVO). The study found that a large fraction of CVs that form after BRVO are extramacular, and the morphology of CVs varies as a function of retinal location.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Weijie Jiang, Siqi He, Logen Liu, Xia Meng, Jing Lu, Juan Li, Tuo Chen, Ying Xu, Qiguo Xiao, Ling Qi, Jia Zhang
Summary: This review summarizes the roles of miRNAs in retinal Muller glial cell function, emphasizing the potential application of miRNAs in retinal repair and regeneration.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Kengadhevi Yogeswaran, Joao M. Furtado, Bahram Bodaghi, Janet M. Matthews, Justine R. Smith
Summary: Ocular toxoplasmosis is a common global infection. This study provides an overview of the current management approach for ocular toxoplasmosis based on a survey completed by uveitis-specialised ophthalmologists from 48 countries. The findings include clinical features, diagnostic methods, treatment options, and follow-up practices. The majority of respondents used clinical examination and serology for diagnosis, and oral trimethoprim-sulfamethoxazole was the most commonly used first-line therapy. Follow-up and prophylaxis against recurrence were also discussed.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Meng Tian, Guodong Zeng, Martin Zinkernagel, Christoph Tappeiner, Sebastian Wolf, Marion R. Munk
Summary: Swept-source wide-field OCTA was used to evaluate CC and choroidal vascular changes in patients with posterior uveitis. The results showed that the mean perfusion density in CC scans was significantly lower in uveitis patients compared to healthy controls, while no significant difference was found in choroidal scans. Patients in the active phase had higher mean perfusion density compared to the inactive phase in choroidal scans. Conclusion: OCTA provides valuable information in patients with posterior uveitis, and CC and choroidal metrics using SS-OCTA have potential in uveitis management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Hashem H. Ghoraba, Wataru Matsumiya, Christopher Or, Hasan Khojasteh, Prem Patel, Irmak Karaca, Jonathan Regenold, Moosa Zaidi, Jaclyn Hwang, Sherin Lajevardi, Negin Yavari, Ngoc Trong Tuong Than, Sung Who Park, Amir Akhavanrezayat, Gunay Uludag, Cigdem Yasar, Loh-Shan B. Leung, Quan Dong Nguyen
Summary: This study describes and correlates electroretinographic responses with clinical and angiographic findings in patients with retinal vasculitis (RV). The study found weak correlations between high FFA scores and vitreous haze grading and cone-generated ffERG responses.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Francesca Bosello, Mark Westcott, Giuseppe Casalino, Georgios Agorogiannis, Rocco Micciolo, Angela Rees, Carlos Pavesio
Summary: This retrospective study investigated the demographics and clinical course of patients with multiple evanescent white dot syndrome (MEWDS) and found that worse presenting vision and young age at presentation were associated with poorer final visual acuity outcomes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sofia Ajamil-Rodanes, Ilaria Testi, Joshua Luis, Anthony G. Robson, Mark Westcott, Carlos Pavesio
Summary: Iluvien implant shows potential therapeutic effects in managing vascular leakage, CMO, and retinal dysfunction in patients with Birdshot retinochoroiditis. However, choroidal lesions appear to persist without a detectable response to treatment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Carol Ren Lin, Abduqodir Toychiev, Reynolds Kwame Ablordeppey, Miduturu Srinivas, Alexandra Benavente-Perez
Summary: The integrity of the aged retinal microvasculature is affected by myopia-induced ocular growth, leading to changes in the number of string vessels and vessel branchpoints. These changes suggest an adaptive reorganization of the retinal microvascular structure during aging and myopia development.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xi Chen, Xiao Wang, Zedu Cui, Qian Luo, Zihua Jiang, Yuke Huang, Jingyi Jiang, Jin Qiu, Yan Li, Keming Yu, Jing Zhuang
Summary: Activation of microglia is crucial in neovascular retinal diseases and understanding its mechanisms can provide potential therapeutic strategies. Through single-cell RNA sequencing, this study reveals that M1 microglia-derived exosomes enhance activation and proangiogenic ability of resting microglia. The communication is mediated by miRNA miR-155-5p, which promotes microglial activation and initiates inflammatory cascade.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Mathematics
Muhammad Arsalan, Adnan Haider, Ja Hyung Koo, Kang Ryoung Park
Summary: Retinal blood vessels are important biomarkers for ophthalmic diseases, but the manual analysis of vascular changes is a tedious task. This study proposes a new network model called VSUL-Net, which accurately extracts retinal vasculature from images without the need for complex preprocessing.
Article
Ophthalmology
Rachael L. Niederer, Priya D. Samalia, Yi-Hsing Chen, Jonathan K. S. Goh, Elisa Eleanor Cornish, Stephen Guest, Peter J. McCluskey, Lyndell L. Lim, Joanne L. Sims, Susan Lightman, Oren Tomkins-Netzer
Summary: Acute posterior multifocal placoid pigment epitheliopathy is a rare but important disease associated with life-threatening complications. The study aimed to determine the incidence of neurological complications and risk factors for stroke and TIA associated with this disease. Results showed that stroke and TIA occurred in 11.7% of subjects, with older age being the only significant risk factor. Vision loss occurred in 7 eyes, and recurrence was observed in 16.7% of patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Alessandro Marchese, Aniruddha Kishandutt Agarwal, Stefano Erba, Antonio Scialdone, Elisabetta Miserocchi, Francesco Bandello, Ugo Introini, Lee M. Jampol, Giuseppe Casalino
Summary: Placoid lesions of the retina can be caused by various inflammatory conditions, making clinical diagnosis and treatment challenging. A systematic approach to differentiate between infectious and non-infectious etiologies, along with in-depth imaging and investigations, is crucial in reaching a correct diagnosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Computer Science, Information Systems
Sangeeta Biswas, Johan Rohdin, Andrii Kavetskyi, Gabriel Saraiva, Angkan Biswas, Martin Drahansky
Summary: The research investigates the bilateral similarity of central retinal blood vessels in the left and right retinas for biometric identification. The performance of human- and deep neural network-based bilateral verification is evaluated and analyzed through experiments on publicly available datasets.
Article
Ophthalmology
Kiran Chandran, Anantharaman Giridhar, Mahesh Gopalakrishnan, Sobha Sivaprasad
Summary: This study found that changes in the interdigitation zone (IDZ) are associated with right-angle vessel (RAV) and can predict the loss of ellipsoid zone (EZ) in Macular Telangiectasia Type-2 (MacTel).
Article
Endocrinology & Metabolism
K. Wongchai, A. Schlotterer, J. Lin, P. M. Humpert, T. Klein, H-P. Hammes, M. Morcos
HORMONE AND METABOLIC RESEARCH
(2016)
Review
Endocrinology & Metabolism
M. Kolibabka, P. Friedrichs, N. Dietrich, T. Fleming, A. Schlotterer, H. -P. Hammes
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2016)
Article
Endocrinology & Metabolism
Michael Mendler, Christin Riedinger, Andrea Schlotterer, Nadine Volk, Thomas Fleming, Stephan Herzig, Peter P. Nawroth, Michael Morcos
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Christin Riedinger, Michael Mendler, Andrea Schlotterer, Thomas Fleming, Juergen Okun, Hans-Peter Hammes, Stephan Herzig, Peter P. Nawroth
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Andrea Schlotterer, Matthias Kolibabka, Jihong Lin, Kuebra Acunman, Nadine Dietrich, Carsten Sticht, Thomas Fleming, Peter Nawroth, Hans-Peter Hammes
Article
Endocrinology & Metabolism
Andrea Schlotterer, Benan Masri, M. Humpert, Bernhard Karl Kraemer, Hans-Peter Hammes, Michael Morcos
Summary: Caenorhabditis elegans is a model organism in neurodegeneration and aging research. SFN and vitamin E have protective effects against glucotoxic damages to the neuronal system and lifespan in C. elegans by preventing the increase in ROS, AGEs, and preserving neuronal structure and function. This highlights the potential therapeutic options of indirect and direct antioxidants in preventing glucotoxic pathologies.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Endocrinology & Metabolism
Sandro Altamura, Katja Muedder, Andrea Schlotterer, Thomas Fleming, Elena Heidenreich, Ruiyue Qiu, Hans-Peter Hammes, Peter Nawroth, Martina U. Muckenthaler
Summary: The study reveals that hepatic iron accumulation may exacerbate symptoms related to metabolic syndrome and type 2 diabetes. It suggests that iron depletion strategies in combination with anti-diabetic drugs could potentially improve insulin resistance and diabetic late complications.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Ying Chen, Jihong Lin, Andrea Schlotterer, Luke Kurowski, Sigrid Hoffmann, Seddik Hammad, Steven Dooley, Malte Buchholz, Jiong Hu, Ingrid Fleming, Hans-Peter Hammes
Summary: miR-124 regulates retinal vasoregression and neuroretinal function in the PKD rat model by inhibiting microglial activation and polarization, reducing pericyte loss, and shifting microglial polarization from a proinflammatory phenotype to an anti-inflammatory phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Fabiola Garcia Cortizo, Daniel Pfaff, Angela Wirth, Andrea Schlotterer, Rebekka Medert, Jakob Morgenstern, Tobias Weber, Hans-Peter Hammes, Thomas Fleming, Peter Paul Nawroth, Marc Freichel, Aurelio A. Teleman
Summary: The study demonstrates that post-translational modifications, specifically the phosphorylation of Glo1 at Tyrosine 136, can enhance Glo1 activity for detoxifying MG. However, high glucose levels lead to decreased Glo1 activity, resulting in elevated MG levels and potentially initiating a detrimental positive feedback loop contributing to diabetic complications.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Katharina Murillo, Azat Samigullin, Per M. Humpert, Thomas Fleming, Kuebra Oezer, Andrea Schlotterer, Hans-Peter Hammes, Michael Morcos
Summary: C. elegans is used to study the molecular pathways linking high glucose levels to diabetic complications. Transient high glucose exposure has positive effects on lifespan and neuronal function in C. elegans, while persistent exposure leads to neuronal damage and decreased lifespan.
Article
Neurosciences
Matthias Kolibabka, Marcus Dannehl, Kuebra Oezer, Katharina Murillo, Hongpeng Huang, Sarah Riemann, Sigrid Hoffmann, Norbert Gretz, Andrea Schlotterer, Yuxi Feng, Hans-Peter Hammes
Summary: Diabetic retinopathy, a microvascular complication of diabetes mellitus, affects the entire neuro-vascular unit, showing specific abnormalities in each compartment. Neurodegeneration, glial activation, and vaso-regression are consistently observed in models of diabetic retinopathy but vary in severity and order.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ying Chen, Andrea Schlotterer, Luke Kurowski, Lin Li, Marcus Dannehl, Hans-Peter Hammes, Jihong Lin
Summary: miR-124 plays a protective role in diabetic retinopathy by reducing vasoregression, glial activation, and inflammatory responses, and improving neuroretinal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jihong Lin, Jiong Hu, Andrea Schlotterer, Jing Wang, Matthias Kolibabka, Khader Awwad, Nadine Dietrich, Kristin Breitschopf, Paulus Wohlfart, Aimo Kannt, Katrin Lorenz, Yuxi Feng, Ruediger Popp, Sigrid Hoffmann, Ingrid Fleming, Hans Peter Hammes
Article
Endocrinology & Metabolism
Patrick Friedrichs, Andrea Schlotterer, Carsten Sticht, Matthias Kolibabka, Paulus Wohlfart, Axel Dietrich, Thomas Linn, Grietje Molema, Hans-Peter Hammes
