Article
Biochemistry & Molecular Biology
Yao-Tseng Wen, Yu-Chieh Ho, Yueh-Chang Lee, Dah-Ching Ding, Pei-Kang Liu, Rong-Kung Tsai
Summary: Research on the safety and efficacy of mesenchymal stem cell (MSC) application in the eye showed that MSC transplantation could cause retinal distortion and injury, while MSC-derived conditioned medium (MDCM) had neuroprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jose C. Pastor, Salvador Pastor-Idoate, Marina Lopez-Paniagua, Marta Para, Francisco Blazquez, Esther Murgui, Veronica Garcia, Rosa M. Coco-Martin
Summary: This study reports the results of a clinical trial on patients with acute non-arteritic optic neuropathy (NA-AION) treated with an intravitreal injection of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs). The study found that the intravitreal application of allogeneic BM-MSCs appeared to be well tolerated and resulted in visual improvement in some patients.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Dongli Li, Yuanyuan Gong
Summary: NAION is a major cause of permanent visual impairment in individuals over 50 years old, with no established treatment plan. MSC-exosome shows potential as a therapeutic approach by promoting angiogenesis and neuro-regeneration. Questions regarding dosing, injection frequency, and treatment duration need to be addressed before clinical testing.
CURRENT STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Anita S. Y. Chan, Sai B. B. Tun, Myoe N. Lynn, Candice Ho, Tin A. Tun, Michael J. A. Girard, Rehena Sultana, Veluchamy A. Barathi, Tin Aung, Makoto Aihara
Summary: Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes. This study found that intravitreal Ngb treatment reduced thinning of the peripapillary minimum rim width, retinal nerve fiber layer thickness, and optic nerve head cupping in a primate model of glaucoma.
Article
Neurosciences
Lai-Yang Zhou, Di Chen, Xin-Ran Guo, Yu-Qian Niu, Yong-Sai Xu, Dong-Fu Feng, Tie-Chen Li
Summary: Traumatic optic neuropathy (TON) causes loss of retinal ganglion cells (RGCs) and their axonal fibers, leading to visual insufficiency. This study investigated the potential neuroprotective effects of Huperzine A (HupA) extracted from a Chinese herb and its ability to enhance neuronal regeneration after optic nerve crush (ONC). The study found that intravitreal injection of HupA promoted RGC survival and axonal regeneration after ONC, through the mTOR pathway, and these effects were blocked by rapamycin. Therefore, HupA shows promise for the clinical treatment of traumatic optic neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Reed Berlet, Stefan Anthony, Beverly Brooks, Zhen-Jie Wang, Nadia Sadanandan, Alex Shear, Blaise Cozene, Bella Gonzales-Portillo, Blake Parsons, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Cesario Borlongan
Summary: Combining stem cell transplantation with rehabilitation therapy presents a promising approach in treating stroke, with potential for better functional outcomes for patients. This comprehensive review assesses the advantages and disadvantages of using this combined therapy to mitigate the devastating effects of stroke.
Article
Cell Biology
Beverly Brooks, Dominique Ebedes, Ahsan Usmani, Joaquin Vega Gonzales-Portillo, Daniel Gonzales-Portillo, Cesario Borlongan
Summary: Ischemic brain injury is a major cause of death worldwide with limited treatment options. Stem cell-based regenerative therapies, specifically mesenchymal stromal cells, show promise in stroke treatment, but further research is needed to fully understand their cell function.
Review
Biochemistry & Molecular Biology
Chikako Nito, Satoshi Suda, Yuko Nitahara-Kasahara, Takashi Okada, Kazumi Kimura
Summary: Regenerative medicine aims to restore human functions by regenerating organs and tissues using stem cells or living tissues. Mesenchymal stem cell therapy, specifically, shows potential in treating cerebral infarction. Dental pulp stem cell therapy, as a cellular therapy strategy, appears promising for patients with ischemic brain injury.
Article
Medicine, General & Internal
Nasser A. Fugara, Zaineh A. Shawareb, Nancy K. Rakkad, Manar L. Barhoum, Bana A. Shawareb, Myrna M. Al-Madani, Mousa V. Al-Madani
Summary: This study aims to report the incidence of non-arteritic ischemic optic neuropathy in diabetic patients treated with intravitreal bevacizumab injection. The study found that intravitreal bevacizumab in diabetic patients may increase the risk of non-arteritic ischemic optic neuropathy, especially in patients receiving more than three injections.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Kai-Chun Cheng, Chien-Chih Chiu, Kuo-Jen Chen, Yo-Chen Chang
Summary: This study aimed to investigate the safety and effectiveness of intravitreal aflibercept in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION). The results showed that intravitreal aflibercept significantly improved visual acuity and resolved disc edema in patients with acute NAION, suggesting it may be an alternative treatment. However, further large-scale investigations are needed to evaluate the long-term therapeutic benefit and safety.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Fatemeh Sanie-Jahromi, Ahmad Mahmoudi, Mohammad Reza Khalili, M. Hossein Nowroozzadeh
Summary: This study reviews recent clinical, animal, and laboratory experiments on the regeneration of RGC using stem cell-derived secretome. Compared to cell transplant, the application of stem cell-derived secretome minimizes immunogenicity while preserving efficacy through its rich content of growth factors.
CURRENT EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tu-Wen Chen, Po-Ying Wu, Yao-Tseng Wen, Tushar Dnyaneshwar Desai, Chin-Te Huang, Pei-Kang Liu, Rong-Kung Tsai
Summary: Supplementing with vitamin B3 has been found to protect retinal ganglion cells from damage and has multiple neuroprotective properties.
Article
Cell Biology
En-Tung Tsai, Shih-Yuan Peng, You-Ren Wu, Tai-Chi Lin, Chih-Ying Chen, Yu-Hao Liu, Yu-Hsin Tseng, Yu-Jer Hsiao, Huan-Chin Tseng, Wei-Yi Lai, Yi-Ying Lin, Yi-Ping Yang, Shih-Hwa Chiou, Shih-Pin Chen, Yueh Chien
Summary: This study generated iMSCs through HLA homozygous iPSCs and examined their therapeutic potential in LHON models. The results showed that iMSCs protected RGCs and improved retinal architecture and electrophysiology in vitro and in vivo.
Article
Cell & Tissue Engineering
Almir Jordao da Silva-Junior, Louise Alessandra Mesentier-Louro, Gabriel Nascimento-dos-Santos, Leandro Coelho Teixeira-Pinheiro, Juliana F. Vasques, Luiza Chimeli-Ormonde, Victor Bodart-Santos, Luiza Rachel Pinheiro de Carvalho, Marcelo Felippe Santiago, Rosalia Mendez-Otero
Summary: Human umbilical Wharton's jelly-derived MSCs and their extracellular vesicles showed sustained neuroprotective effects and promoted regeneration of RGCs in a rat model of optic nerve crush. This highlights the potential of cell therapy using human MSCs for neuroprotection and axon regeneration after optic nerve injury.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell & Tissue Engineering
Jian-feng Zhou, Yu Xiong, Xiaodong Kang, Zhigang Pan, Qiangbin Zhu, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng, Pantelis Stavrinou
Summary: Intracerebral hemorrhage is a highly destructive brain disease with main risk factors such as hypertension and drug abuse. Stem cells and exosomes are considered as new methods for treatment, but more clinical studies are needed to confirm their safety and efficacy.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pharmacology & Pharmacy
Deyanira Barbosa-Alfaro, Vanessa Andres-Guerrero, Ivan Fernandez-Bueno, Maria Teresa Garcia-Gutierrez, Esther Gil-Alegre, Irene Teresa Molina-Martinez, Jose Carlos Pastor-Jimeno, Rocio Herrero-Vanrell, Irene Bravo-Osuna
Summary: In this study, dexamethasone-loaded PLGA microspheres were successfully prepared and showed sustained release in vitro and good ocular tolerance in vivo. This provides a promising alternative for treating chronic diseases of the posterior segment of the eye.
Article
Clinical Neurology
Andres da Silva-Candal, Antia Custodia, Iria Lopez-Dequidt, Manuel Rodriguez-Yanez, Maria Luz Alonso-Alonso, Paulo Avila-Gomez, Jose M. Pumar, Jose Castillo, Tomas Sobrino, Francisco Campos, Ramon Iglesias-Rey, Pablo Hervella
Summary: The aim of this study was to investigate the frequency and intensity of leukoaraiosis (LA) in symptomatic patients compared to asymptomatic subjects, and its association with soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK). The results showed a higher prevalence and intensity of LA in symptomatic patients, and a significant correlation between LA degree and sTWEAK levels.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Ramon Iglesias-Rey, Antia Custodia, Maria Luz Alonso-Alonso, Iria Lopez-Dequidt, Manuel Rodriguez-Yanez, Jose M. Pumar, Jose Castillo, Tomas Sobrino, Francisco Campos, Andres da Silva-Candal, Pablo Hervella
Summary: This study aimed to investigate the association between smoking habit and the functional outcome of patients with acute ischemic stroke undergoing reperfusion treatment. The results showed that smoking was associated with a good functional outcome, and the decrease in sTWEAK levels was also associated with a good functional outcome in smoker patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Manuel Rodriguez-Yanez, Iria Lopez-Dequidt, Jose M. Pumar, Antonio J. Mosqueira, Alberto Ouro, Paulo Avila-Gomez, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: Research on malignant infarction of the middle cerebral artery found that an increase in body temperature within the first 24 hours is an independent predictor of poor outcomes, while antihyperthermic treatment is associated with better outcomes and higher survival rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Alberto Ouro, Clara Correa-Paz, Elena Maqueda, Antia Custodia, Marta Aramburu-Nunez, Daniel Romaus-Sanjurjo, Adrian Posado-Fernandez, Maria Candamo-Lourido, Maria Luz Alonso-Alonso, Pablo Hervella, Ramon Iglesias-Rey, Jose Castillo, Francisco Campos, Tomas Sobrino
Summary: Ischemic stroke is a major cause of disability worldwide, and there is currently a lack of successful neuroprotective drugs and recovery strategies. Therefore, it is necessary to further study and explore new therapeutic approaches. Sphingolipid metabolism plays an important role in the occurrence and progression of stroke.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Clinical Neurology
Pablo Hervella, Maria Luz Alonso-Alonso, Maria Perez-Mato, Manuel Rodriguez-Yanez, Susana Arias-Rivas, Iria Lopez-Dequidt, Jose M. Pumar, Tomas Sobrino, Francisco Campos, Jose Castillo, Ramon Iglesias-Rey
Summary: Inflammatory biomarkers are strongly associated with wake-up ischemic stroke episodes, while wake-up ischemic stroke is associated with lower levels of vitamin D. These findings suggest that vitamin D deficiency could be a therapeutic target to reduce the occurrence of wake-up ischemic stroke events.
Review
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Alberto Ouro, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: Blood-brain barrier dysfunction is closely associated with cerebrovascular disease, but its detrimental or reparative effects depend on the stage of stroke. Understanding the structure, function, and chronic alterations of the BBB related to ischemic stroke is important for new drug development and clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Maria Luz Alonso-Alonso, Maria Perez-Mato, Ana Sampedro-Viana, Clara Correa-Paz, Paulo Avila-Gomez, Tomas Sobrino, Francisco Campos, Jose Castillo, Ramon Iglesias-Rey, Pablo Hervella
Summary: In this study, a new dual MRI nanoparticle was developed to predict the efficacy of recanalization treatment and improve the triage of ischemic stroke patients by targeting the fibrin content of blood clots.
Article
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Manuel Rodriguez-Yanez, Iria Lopez-Dequidt, Jose M. Pumar, Antonio J. Mosqueira, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: The circadian system has an influence on body temperature and stroke onset. This study explores the impact of temperature chronobiology on stroke onset and functional outcomes, as well as the variation of blood biomarkers based on stroke onset time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Irene Andres-Blasco, Alex Gallego-Martinez, Ximena Machado, Javier Cruz-Espinosa, Salvatore Di Lauro, Ricardo Casaroli-Marano, Victor Alegre-Ituarte, Jose Fernando Arevalo, Maria Dolores Pinazo-Duran
Summary: The study aimed to evaluate the molecules related to oxidative stress, inflammation, angiogenesis, and apoptosis in patients with proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). By investigating their correlation in the plasma and vitreous body, as well as examining ophthalmological examination data, the study found that oxidative stress and inflammation were increased in the plasma and vitreous samples from patients with PDR/DME, while antioxidant capacity was decreased. The study suggests that exploring the relationship between these potential biomarkers in the plasma and vitreous may help detect early molecular changes in PDR/DME and monitor therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Rafael Gabriel, Nisa Boukichou-Abdelkader, Aleksandra Gilis-Januszewska, Konstantinos Makrilakis, Ricardo Gomez-Huelgas, Zdravko Kamenov, Bernhard Paulweber, Ilhan Satman, Predrag Djordjevic, Abdullah Alkandari, Asimina Mitrakou, Nebojsa Lalic, Jesus Egido, Sebastian Mas-Fontao, Jean Henri Calvet, Jose Carlos Pastor, Jaana Lindstrom, Marcus Lind, Tania Acosta, Luis Silva, Jaakko Tuomilehto
Summary: The objective of this study was to compare the impact of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. The results showed that the use of metformin alone, linagliptin alone, or the combination of both reduced the risk of small fiber peripheral neuropathy and slowed down the decrease in estimated glomerular filtration rate compared to the placebo. These findings suggest that treatment with metformin and linagliptin, either alone or in combination, can effectively protect prediabetes patients from developing peripheral nerve diseases and maintain kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jimena Fernandez-Carneado, Ana Almazan-Moga, Dolores T. Ramirez-Lamelas, Cristina Cusco, Jose Ignacio Alonso de la Fuente, J. Carlos Pastor, Maria Isabel Lopez Galvez, Berta Ponsati
Summary: This study aimed to investigate whether the quantification of microaneurysms (MAs), hemorrhages (Hmas), and hard exudates (HEs) in the central retinal field could predict the severity of diabetic retinopathy (DR). The results showed that the number of MAs, Hmas, and HEs increased as the severity of DR progressed. These findings suggest that analyzing retinal lesions in the central field can provide valuable information on the severity level of DR and serve as a clinical tool for assessing DR grading in routine eyecare.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Salvador Pastor-Idoate, Milagros Mateos-Olivares, Eva Maria Sobas, Miguel Marcos, Alfredo Toribio, Jose Carlos Pastor, Ricardo Usategui Martin
Summary: This study aims to assess the effects of melatonin and blocking filters on patients with RP and their effectiveness in improving stress and sleep problems. The study is still at the protocol stage and has not yet started.
JMIR RESEARCH PROTOCOLS
(2023)
Review
Cell & Tissue Engineering
Maria Luz Alonso-Alonso, Laura Garcia-Posadas, Yolanda Diebold
Summary: Interest in AT-MSC-EVs for therapeutic potential has grown, with numerous proteins and miRNAs identified within, primarily involved in binding function and participating in processes like signal transduction and gene silencing. The therapeutic effects of AT-MSC-EVs are highlighted in biological processes such as inflammation, angiogenesis, and apoptosis.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Ophthalmology
Marta Para-Prieto, Raul Martin, Sara Crespo, Laura Mena-Garcia, Andres Valisena, Lisandro Cordero, Gloria Gonzalez Fernandez, Juan F. Arenillas, Nieves Tellez, Jose Carlos Pastor
Summary: The study evaluated the agreement of pRNFL and FT measurements among different SD-OCT instruments in MS patients and healthy controls. MS eyes with a history of ON showed thinner pRNFL and FT, while healthy subjects and MS eyes without ON had similar thickness. Devices like PRIMUS and CIRRUS OCT showed better agreement compared to 3D OCT.
CLINICAL OPHTHALMOLOGY
(2021)
