Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

Exposure to the plasticizer, Di-(2-ethylhexyl) phthalate during juvenile period exacerbates autism-like behavior in adult BTBR T + tf/J mice due to DNA hypomethylation and enhanced inflammation in brain and systemic immune cells

(2021) Ahmed Nadeem et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

(2020) Aoife M. McGinley et al.   IMMUNITY

Bruton’s tyrosine kinase inhibitor suppresses imiquimod-induced psoriasis-like inflammation in mice through regulation of IL-23/IL-17A in innate immune cells

(2020) Ahmed Nadeem et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination

(2020) Hsueh Chung Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells

(2020) Naif O. Al-Harbi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting STAT3 in cancer and autoimmune diseases

(2020) Tohid Gharibi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

(2020) Mirre De Bondt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Icariin ameliorates the progression of experimental autoimmune encephalomyelitis by down-regulating the major inflammatory signal pathways in a mouse relapse-remission model of multiple sclerosis

(2020) Hengri Cong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

(2019) Jonathan J. Cho et al.   Nature Communications

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis

(2019) Zhi-Hui Li et al.   Aging-US

Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

(2018) Kathryn Prame Kumar et al.   CELL AND TISSUE RESEARCH

Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients

(2018) Ester Canto et al.   Journal of Neuroinflammation

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-Derived Nitrative Damage

(2018) Wenting Li et al.   Frontiers in Physiology

Recent advances on the crosstalk between neutrophils and B or T lymphocytes

(2018) Sara Costa et al.   IMMUNOLOGY

New Insights into the Role of IL-1β in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2017) Chih-Chung Lin et al.   JOURNAL OF IMMUNOLOGY

STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model

(2017) Tsubasa Yokota et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Differentiation and Transmigration of CD4 T Cells in Neuroinflammation and Autoimmunity

(2017) Sandip Ashok Sonar et al.   Frontiers in Immunology

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

(2016) A. C. Gavino et al.   ALLERGY

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

(2016) Sébastien A. Lévesque et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice

(2015) Lindsay J. Edwards et al.   CLINICAL IMMUNOLOGY

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation

(2015) M. Paterka et al.   EMBO JOURNAL

Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain barrier integrity and ameliorates disease severity

(2015) Hao Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

(2015) Laura Hertwig et al.   Multiple Sclerosis Journal

Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica

(2015) Laura Hertwig et al.   Multiple Sclerosis Journal

Loss of STAT3 in CD4 + T Cells Prevents Development of Experimental Autoimmune Diseases

(2014) Xuebin Liu et al.   JOURNAL OF IMMUNOLOGY

Airway and systemic oxidant-antioxidant dysregulation in asthma: A possible scenario of oxidants spill over from lung into blood

(2014) A. Nadeem et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs

(2013) K. Steinbach et al.   JOURNAL OF IMMUNOLOGY

Gene expression analysis of relapsing–remitting, primary progressive and secondary progressive multiple sclerosis

(2013) R Ratzer et al.   Multiple Sclerosis Journal

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Neutrophils in multiple sclerosis are characterized by a primed phenotype

(2011) Matthias Naegele et al.   JOURNAL OF NEUROIMMUNOLOGY

Independent replication of STAT3 association with multiple sclerosis risk in a large German case–control sample

(2011) Christina M. Lill et al.   NEUROGENETICS

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

(2010) Eveliina Jakkula et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Th17 cells in autoimmune demyelinating disease

(2010) Benjamin Matthew Segal   Seminars in Immunopathology

Innate and Adaptive Autoimmunity Directed to the Central Nervous System

(2009) Roopa Bhat et al.   NEURON

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis

(2008) Giovanni Frisullo et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET