Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases

Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis

(2021) Fang-tian Bu et al.   Molecular Therapy-Nucleic Acids

Long non‐coding RNA H19: A key player in liver diseases

(2021) Yanyan Wang et al.   HEPATOLOGY

Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4

(2021) Huawei Xiong et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

A comprehensive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease

(2021) Arezoo Gowhari Shabgah et al.   Nutrition & Metabolism

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

(2021) Fanwu Chi et al.   Frontiers in Oncology

Circular RNA Microarray Analyses in Hepatic Ischemia-Reperfusion Injury With Ischemic Preconditioning Prevention

(2021) Xinyao Tian et al.   Frontiers in Medicine

Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3

(2020) Dong Ji et al.   Aging-US

Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR‐146a‐5p

(2020) Yuhan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circular RNA TUBD1 Acts as the miR-146a-5p Sponge to Affect the Viability and Pro-Inflammatory Cytokine Production of LX-2 Cells through the TLR4 Pathway

(2020) Hao Niu et al.   RADIATION RESEARCH

Antagonizing circRNA_002581–miR-122–CPEB1 axis alleviates NASH through restoring PTEN–AMPK–mTOR pathway regulated autophagy

(2020) Xi Jin et al.   Cell Death & Disease

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

(2020) Zhicong Zhao et al.   JOURNAL OF HEPATOLOGY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Circular RNA hsa_circ_0004812 impairs IFN-induced immune response by sponging miR-1287-5p to regulate FSTL1 in chronic hepatitis B

(2020) Liangdong Zhang et al.   Virology Journal

Epigenetics factors in nonalcoholic fatty liver disease

(2020) Carlos Jose Pirola et al.   Expert Review of Gastroenterology & Hepatology

Circular RNA HIPK3: A Key Circular RNA in a Variety of Human Cancers

(2020) Jingyuan Wen et al.   Frontiers in Oncology

The knowns and unknowns of treatment for alcoholic hepatitis

(2020) Tejasav S Sehrawat et al.   Lancet Gastroenterology & Hepatology

hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis

(2020) Shan Li et al.   Aging-US

The Role of the Liver-Specific microRNA, miRNA-122 in the HCV Replication Cycle

(2020) Rasika D. Kunden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs

(2020) Lele Zhang et al.   Molecular Cancer

Novel insights into the interplay between m6A modification and noncoding RNAs in cancer

(2020) You-Cai Yi et al.   Molecular Cancer

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells

(2020) Tzu-Chun Chen et al.   PLoS Pathogens

Gut microbiota regulate tumor metastasis via circRNA/miRNA networks

(2020) Zhuxian Zhu et al.   Gut Microbes

Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis

(2020) Hui Jin et al.   Frontiers in Cell and Developmental Biology

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

RNA-seq Used to Explore circRNA Expression and Identify Key circRNAs During the DNA Synthesis Phase of Mice Liver Regeneration

(2020) Jinfu Zhang et al.   DNA AND CELL BIOLOGY

Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid‐related diseases

(2020) Chen Chen et al.   FEBS Journal

Comprehensive analysis of circular RNAs from steatotic livers after ischemia and reperfusion injury by next‐generation RNA sequencing

(2020) Xiaoye Qu et al.   FEBS LETTERS

Circular RNAs associated with a mouse model of concanavalin A‐induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis

(2020) Yang Liu et al.   FEBS Open Bio

Circular RNAs: Rising stars in lipid metabolism and lipid disorders

(2020) Guangli Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data

(2020) Xinlu Yuan et al.   Journal of Translational Medicine

Circular RNAs in liver diseases: Mechanisms and therapeutic targets

(2020) Li-Yun Fu et al.   LIFE SCIENCES

Alcohol, liver disease and the gut microbiota

(2019) Jasmohan S. Bajaj   Nature Reviews Gastroenterology & Hepatology

Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury

(2019) Pengpeng Zhang et al.   Scientific Reports

Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis

(2019) Qiang Ou et al.   Molecular Medicine Reports

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

Intercellular Communication between Hepatic Cells in Liver Diseases

(2019) Keisaku Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Circbank: a comprehensive database for circRNA with standard nomenclature

(2019) Ming Liu et al.   RNA Biology

Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks

(2019) Mingzhe Zhu et al.   BMC Complementary and Alternative Medicine

Past, present, and future of circ RNA s

(2019) Ines Lucia Patop et al.   EMBO JOURNAL

CircMTO1 inhibits liver fibrosis via regulation of miR‐17‐5p and Smad7

(2019) Wei Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Advances in epigenetics link genetics to the environment and disease

(2019) Giacomo Cavalli et al.   NATURE

Roles of circular RNAs in immune regulation and autoimmune diseases

(2019) Zheng Zhou et al.   Cell Death & Disease

Role of identified RNA N6-methyladenosine methylation in liver

(2019) Kechen Xu et al.   ANALYTICAL BIOCHEMISTRY

Circular RNA 4099 aggravates hydrogen peroxide-induced injury by down-regulating microRNA-706 in L02 cells

(2019) Yuling Li et al.   LIFE SCIENCES

Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms

(2019) Lipeng Qiu et al.   LIFE SCIENCES

Molecular mechanisms of circular RNAs, transforming growth factor‐ β , and long noncoding RNAs in hepatocellular carcinoma

(2019) Wenkang Shang et al.   Cancer Medicine

TGF-β- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223

(2019) Wentao Liu et al.   Aging-US

Non-coding RNA associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis

(2019) Farooq Riaz et al.   CURRENT GENE THERAPY

Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis

(2019) Hongwu Meng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CircularRNA as novel biomarkers in liver diseases

(2019) Yueh Chien et al.   Journal of the Chinese Medical Association

Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease

(2019) Xinyi Lu et al.   TOXICOLOGY LETTERS

RNA Sequencing Reveals a Comprehensive Circular RNA Expression Profile in a Mouse Model of Alcoholic Liver Disease

(2019) Xiaobing Dou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Role of miRNA sponges in hepatocellular carcinoma

(2019) Dandan Li et al.   CLINICA CHIMICA ACTA

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice

(2018) Jun Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease

(2018) Abhishek Satishchandran et al.   GASTROENTEROLOGY

Is miR-21 a potent target for liver fibrosis?

(2018) Sanchuan Lai et al.   HEPATOLOGY

Circular RNAs are differentially expressed in liver ischemia/reperfusion injury model

(2018) Zhiqiang Ye et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Differential expression profile of hepatic circular RNAs in chronic hepatitis B

(2018) T.-C. Zhou et al.   JOURNAL OF VIRAL HEPATITIS

Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges

(2018) Isabelle Jost et al.   RNA Biology

circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

(2018) Xing-Ya Guo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels

(2018) Kazuma Sekiba et al.   Oncotarget

The Emerging Role of Circular RNAs in Hepatocellular Carcinoma

(2018) Li-Peng Qiu et al.   Journal of Cancer

Circular RNAs in hepatocellular carcinoma: Functions and implications

(2018) Liyun Fu et al.   Cancer Medicine

Hepatitis B virus infection

(2018) Man-Fung Yuen et al.   Nature Reviews Disease Primers

CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway

(2018) Peifei Li et al.   DIGESTIVE DISEASES AND SCIENCES

Preliminary screening and functional analysis of circular RNAs associated with hepatic stellate cell activation

(2018) Yuping Zhou et al.   GENE

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Circular RNAs: Characteristics, Function and Clinical Significance in Hepatocellular Carcinoma

(2018) Man Wang et al.   Cancers

The genetics of primary biliary cholangitis

(2018) Atsushi Tanaka et al.   CURRENT OPINION IN GASTROENTEROLOGY

Relationship between Telomere Maintenance and Liver Disease

(2018) Abbey Barnard et al.   Gut and Liver

Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes

(2018) Yuping Zhou et al.   HEPATOLOGY RESEARCH

Chronic hepatitis B virus infection

(2018) Wai-Kay Seto et al.   LANCET

The roles of lncRNA in hepatic fibrosis

(2018) Hu Peng et al.   Cell and Bioscience

Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation

(2017) Yuhan Chen et al.   GENE

Circular RNAs: Biogenesis, properties, roles, and their relationships with liver diseases

(2017) Ting Yao et al.   HEPATOLOGY RESEARCH

Progress and prospects of circular RNAs in Hepatocellular carcinoma: Novel insights into their function

(2017) Ji Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis

(2017) Xing-Ya Guo et al.   Oxidative Medicine and Cellular Longevity

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis

(2017) Xing-Ya Guo et al.   Biomed Research International

Current Research on Non-Coding Ribonucleic Acid (RNA)

(2017) Jing Wang et al.   Genes

Circular RNAs (circRNAs) in Health and Disease

(2017) et al.   Genes

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Stem/progenitor cells in liver regeneration

(2016) Tohru Itoh   HEPATOLOGY

Sinusoidal communication in liver fibrosis and regeneration

(2016) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

Messenger RNA modifications: Form, distribution, and function

(2016) W. V. Gilbert et al.   SCIENCE

Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122

(2016) Peter Sarnow et al.   Annual Review of Virology

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

(2016) Erika Lasda et al.   PLoS One

Comparison of circular RNA prediction tools

(2015) Thomas B. Hansen et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs in Alcoholic Liver Disease

(2015) Abhishek Satishchandran et al.   SEMINARS IN LIVER DISEASE

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

(2014) Ali A Mokdad et al.   BMC Medicine

Epigenetics in liver disease

(2014) Derek A. Mann   HEPATOLOGY

Long noncoding RNA in liver diseases

(2014) Kenji Takahashi et al.   HEPATOLOGY

The global burden of liver disease: The major impact of China

(2014) Fu-Sheng Wang et al.   HEPATOLOGY

Regulation of the Extrinsic Apoptotic Pathway by MicroRNA-21 in Alcoholic Liver Injury

(2014) Heather Francis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

(2013) Carmen Peralta et al.   JOURNAL OF HEPATOLOGY

Autoimmune liver disease, autoimmunity and liver transplantation

(2013) Marco Carbone et al.   JOURNAL OF HEPATOLOGY

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Gastrointestinal and liver diseases: genetic and epigenetic markers

(2011) H. E. Blum   GUT

Lipins: Multifunctional Lipid Metabolism Proteins

(2010) Lauren S. Csaki et al.   Annual Review of Nutrition

A review of mast cells and liver disease: What have we learned?

(2010) Heather Francis et al.   DIGESTIVE AND LIVER DISEASE

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS