Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice

Interplay Between NLRP3 Inflammasome and Autophagy

(2020) Monika Biasizzo et al.   Frontiers in Immunology

The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

(2019) Rhiannon I. Campden et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice

(2018) Seiji Watanabe et al.   JOURNAL OF NEUROCHEMISTRY

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches

(2017) Silvano Esposito et al.   Journal of Global Antimicrobial Resistance

Legumain is activated in macrophages during pancreatitis

(2016) Laura E. Edgington-Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of inflammasomes by autophagy

(2016) Tatsuya Saitoh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis

(2016) Wei Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The protease inhibitor cystatin C down-regulates the release of IL-β and TNF-α in lipopolysaccharide activated monocytes

(2016) Susanne Thiesen Gren et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

(2015) Gregory M. Orlowski et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

(2015) Prajwal Gurung et al.   Scientific Reports

Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways

(2014) Katarina Maher et al.   FEBS LETTERS

A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia

(2014) Katarina Maher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

(2014) S Watanabe et al.   Cell Death & Disease

Role of p38 MAPK and STAT3 in lipopolysaccharide-stimulated mouse alveolar macrophages

(2014) AIHONG MENG et al.   Experimental and Therapeutic Medicine

Caspase-11: The driving factor for noncanonical inflammasomes

(2013) Elena Viganò et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cystatin C Properties Crucial for Uptake and Inhibition of Intracellular Target Enzymes

(2013) Hanna Wallin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Cystatins in Immune System

(2013) Špela Magister et al.   Journal of Cancer

Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion

(2012) Pei-Chun Liao et al.   INFLAMMATION RESEARCH

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

(2011) Christian Klotz et al.   PLoS Pathogens

Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy

(2010) Gurjinder Kaur et al.   AMERICAN JOURNAL OF PATHOLOGY

Cystatin cures visceral leishmaniasis by NF-κB-mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tpl2-ERK pathway

(2010) Susanta Kar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

(2010) Belen Tizon et al.   PLoS One

Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: Involvement of ERK1/2, NF-κB and JAK/STAT pathways

(2009) Susanta Kar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage responses to interferon-γ are dependent on cystatin C levels

(2009) Katarina H. Frendéus et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Internalization of cystatin C in human cell lines

(2008) Ulf Ekström et al.   FEBS Journal

Cystatins: Biochemical and structural properties, and medical relevance

(2008) ">Vito Turk   Frontiers in Bioscience-Landmark

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON