Extracellular Vesicles in Lung Cancer: Prospects for Diagnostic and Therapeutic Applications

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis

(2021) Ming-Yue Li et al.   Molecular Cancer

Next-Generation Cancer Biomarkers: Extracellular Vesicle DNA as a Circulating Surrogate of Tumor DNA

(2021) Samuel Amintas et al.   Frontiers in Cell and Developmental Biology

Diverse Effects of Exosomes on COVID-19: A Perspective of Progress From Transmission to Therapeutic Developments

(2021) Sangiliyandi Gurunathan et al.   Frontiers in Immunology

Expression of Serum Exosomal miRNA 122 and Lipoprotein Levels in Dogs Naturally Infected by Leishmania infantum: A Preliminary Study

(2020) Antonio Di Loria et al.   Animals

Role of exosomal microRNAs in lung cancer biology and clinical applications

(2020) Chengping Hu et al.   CELL PROLIFERATION

The function and clinical application of extracellular vesicles in innate immune regulation

(2020) Xiaoxue Zhou et al.   Cellular & Molecular Immunology

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles

(2020) Jonathan M. Carnino et al.   Frontiers in Immunology

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

Origin of circulating free DNA in patients with lung cancer

(2020) Tomonori Abe et al.   PLoS One

Extracellular Vesicles Mediate B Cell Immune Response and Are a Potential Target for Cancer Therapy

(2020) Taketo Kato et al.   Cells

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

(2020) Karim Sidhom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Convergence of Extracellular Vesicle and GPCR Biology

(2020) Maarten P. Bebelman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Immunoregulatory Roles of Extracellular Vesicles and Associated Therapeutic Applications in Lung Cancer

(2020) Zhengrong Yin et al.   Frontiers in Immunology

Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee

(2020) Felix Royo et al.   Cells

Extracellular vesicle analysis allows for identification of invasive IPMN

(2020) Katherine S. Yang et al.   GASTROENTEROLOGY

miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer

(2020) Shen Zhong et al.   Translational Research

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

(2019) Peng Zhang et al.   Nature Biomedical Engineering

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Application of high-mannose-type glycan-specific lectin from Oscillatoria Agardhii for affinity isolation of tumor-derived extracellular vesicles

(2019) Mika Yamamoto et al.   ANALYTICAL BIOCHEMISTRY

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

(2019) Dong Ha Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Immunotherapy Based on Dendritic Cell-Targeted/-Derived Extracellular Vesicles—A Novel Strategy for Enhancement of the Anti-tumor Immune Response

(2019) Oleg Markov et al.   Frontiers in Pharmacology

Sequential phosphoproteomics and N-glycoproteomics of plasma-derived extracellular vesicles

(2019) Hillary Andaluz Aguilar et al.   Nature Protocols

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

Exosomal lipids for classifying early and late stage non-small cell lung cancer

(2018) Teresa W.M. Fan et al.   ANALYTICA CHIMICA ACTA

Exosome-Based Detection ofEGFRT790M in Plasma from Non–Small Cell Lung Cancer Patients

(2018) Elena Castellanos-Rizaldos et al.   CLINICAL CANCER RESEARCH

Tumor exosomes block dendritic cells maturation to decrease the T cell immune response

(2018) Yongling Ning et al.   IMMUNOLOGY LETTERS

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Molecular interactions at the surface of extracellular vesicles

(2018) Edit I. Buzás et al.   Seminars in Immunopathology

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

A Comparison of Traditional and Novel Methods for the Separation of Exosomes from Human Samples

(2018) Li-Li Yu et al.   Biomed Research International

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy

(2017) Uchini Kosgodage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

(2017) Feng Wei et al.   Molecular Cancer

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

(2017) Michael L. Merchant et al.   Nature Reviews Nephrology

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Droplet-Free Digital Enzyme-Linked Immunosorbent Assay Based on a Tyramide Signal Amplification System

(2016) Kenji Akama et al.   ANALYTICAL CHEMISTRY

STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells

(2016) Yi Liu et al.   CANCER LETTERS

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

(2016) Xiaoxia Li et al.   Journal of Hematology & Oncology

Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer

(2016) Birgitte Sandfeld-Paulsen et al.   Journal of Thoracic Oncology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lung cancer exosomes as drivers of epithelial mesenchymal transition

(2016) Mohammad A. Rahman et al.   Oncotarget

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells

(2016) Akhil Srivastava et al.   Scientific Reports

A novel affinity-based method for the isolation of highly purified extracellular vesicles

(2016) Wataru Nakai et al.   Scientific Reports

Acoustic Purification of Extracellular Microvesicles

(2015) Kyungheon Lee et al.   ACS Nano

Targeting Microparticle Biogenesis: A Novel Approach to the Circumvention of Cancer Multidrug Resistance

(2015) Ariane Roseblade et al.   CURRENT CANCER DRUG TARGETS

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles

(2015) Yi-Ge Zhou et al.   Small

Accessing Genetic Information with Liquid Biopsies

(2015) Xuyu Cai et al.   TRENDS IN GENETICS

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

(2014) Mei He et al.   LAB ON A CHIP

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

(2014) Hyungsoon Im et al.   NATURE BIOTECHNOLOGY

Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells via cGAS/STING Signaling

(2014) H. Zhang et al.   Cancer Immunology Research

Epidermal Growth Factor Receptor-Containing Exosomes Induce Tumor-Specific Regulatory T Cells

(2013) Shao-hong Huang et al.   CANCER INVESTIGATION

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

(2013) N. S. Jahchan et al.   Cancer Discovery

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Oncogenic extracellular vesicles in brain tumor progression

(2012) Esterina D’Asti et al.   Frontiers in Physiology

Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

(2011) Sanyukta Rana et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine

(2011) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Small Molecule Inhibitors of Acid Sphingomyelinase

(2010) Christoph Arenz   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

(2010) Katrin Strauss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE