Aberrantly Glycosylated IgA1 in IgA Nephropathy: What We Know and What We Don’t Know

Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy

(2021) Zina Moldoveanu et al.   JOURNAL OF AUTOIMMUNITY

C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin a nephropathy

(2020) Yue Xing et al.   BMC Nephrology

Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation

(2020) Yukako Ohyama et al.   Scientific Reports

Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy

(2020) Lu Zhao et al.   CLINICAL IMMUNOLOGY

Small RNA deep sequencing reveals novel miRNAs in peripheral blood mononuclear cells from patients with IgA nephropathy

(2020) Ziyan Wang et al.   Molecular Medicine Reports

Comprehensive analysis of circRNA expression profiles and circRNA-associated competing endogenous RNA networks in IgA nephropathy

(2020) Haiyang Liu et al.   PeerJ

microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA Nephropathy

(2020) Chan Liu et al.   Frontiers in Immunology

Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression

(2019) Dita Maixnerova et al.   PLoS One

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics

(2019) Yoshiki Narimatsu et al.   MOLECULAR & CELLULAR PROTEOMICS

Distinct Fc alpha receptor N-glycans modulate the binding affinity to immunoglobulin A (IgA) antibodies

(2019) Kathrin Göritzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunostaining for galactose-deficient immunoglobulin A is not specific for primary immunoglobulin A nephropathy

(2019) Clarissa A Cassol et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Glomerular Immunodeposits of Patients with IgA Nephropathy Are Enriched for IgG Autoantibodies Specific for Galactose-Deficient IgA1

(2019) Dana V. Rizk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6–mediated pathways in IgA nephropathy

(2019) Yuko Makita et al.   KIDNEY INTERNATIONAL

Sweet Control: MicroRNA Regulation of the Glycome

(2019) Chu T. Thu et al.   BIOCHEMISTRY

The role of complement in IgA nephropathy

(2019) Agustin Tortajada et al.   MOLECULAR IMMUNOLOGY

IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis

(2018) Hitoshi Suzuki et al.   KIDNEY INTERNATIONAL

Recent advances in the physiopathology of IgA nephropathy

(2018) Renato C. Monteiro   Nephrologie & Therapeutique

Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy

(2018) William J. Placzek et al.   PLoS One

Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients

(2018) Colin Reily et al.   BIOTECHNIQUES

Aberrant Glycosylation of the IgA1 Molecule in IgA Nephropathy

(2018) Jan Novak et al.   SEMINARS IN NEPHROLOGY

Difference in IgA1 O-glycosylation between IgA deposition donors and IgA nephropathy recipients

(2018) Shigeaki Nakazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy

(2018) Yukihiro Wada et al.   PLoS One

Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1

(2017) Daniel P. Gale et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

β1,4-galactosyltransferase 1 is a novel receptor for IgA in human mesangial cells

(2017) Karen Molyneux et al.   KIDNEY INTERNATIONAL

A Novel Biomarker for Post-Transplant Recurrent IgA Nephropathy

(2017) S. Temurhan et al.   TRANSPLANTATION PROCEEDINGS

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

(2017) Krzysztof Kiryluk et al.   PLoS Genetics

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Toll-Like Receptor 9 Stimulation Induces Aberrant Expression of a Proliferation-Inducing Ligand by Tonsillar Germinal Center B Cells in IgA Nephropathy

(2016) Masahiro Muto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction

(2016) Richard A. Lafayette et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy

(2016) Grazia Serino et al.   KIDNEY INTERNATIONAL

The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy

(2016) Barbora Knoppova et al.   Frontiers in Immunology

Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review

(2016) Qiang Sun et al.   PLoS One

DEFA gene variants associated with IgA nephropathy in a Chinese population

(2015) Y Y Qi et al.   GENES AND IMMUNITY

Current Understanding of the Role of Complement in IgA Nephropathy

(2015) N. Maillard et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes

(2015) Laureline Berthelot et al.   KIDNEY INTERNATIONAL

Role of let-7b in the regulation ofN-acetylgalactosaminyltransferase 2 in IgA nephropathy

(2015) Grazia Serino et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Novel lectin-independent approach to detect galactose-deficient IgA1 in IgA nephropathy

(2015) Junichi Yasutake et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy

(2014) Yusuke Suzuki et al.   Clinical and Experimental Nephrology

Cytokines Alter IgA1O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes

(2014) Hitoshi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of two monoclonal antibodies against a synthetic glycopeptide, an analogue to the hypo-galactosylated IgA1 hinge region

(2014) Yoshiyuki Hiki et al.   JOURNAL OF NEPHROLOGY

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

(2014) Krzysztof Kiryluk et al.   NATURE GENETICS

Enzymatic Sialylation of IgA1 O-Glycans: Implications for Studies of IgA Nephropathy

(2014) Kazuo Takahashi et al.   PLoS One

Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease

(2014) Colin Reily et al.   Journal of Immunology Research

Th1/Th2 polarization in tonsillar lymphocyte form patients with IgA nephropathy

(2013) Liyu He et al.   RENAL FAILURE

IgA Nephropathy: Molecular Mechanisms of the Disease

(2012) Jiri Mestecky et al.   Annual Review of Pathology-Mechanisms of Disease

Quantitative change of IgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA nephropathy

(2012) Hirotsugu Iwatani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohnʼs disease

(2012) Takahiro Inoue et al.   INFLAMMATORY BOWEL DISEASES

Integrin α1/β1 and α2/β1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy

(2012) Yoshikatsu Kaneko et al.   INTERNATIONAL IMMUNOLOGY

Transglutaminase is essential for IgA nephropathy development acting through IgA receptors

(2012) Laureline Berthelot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy

(2012) G. Serino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An update on the pathogenesis and treatment of IgA nephropathy

(2012) Joanna K. Boyd et al.   KIDNEY INTERNATIONAL

The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression

(2012) Na Zhao et al.   KIDNEY INTERNATIONAL

Pathogenesis of IgA nephropathy

(2012) Kar Neng Lai   Nature Reviews Nephrology

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

(2012) Jan Novak et al.   Seminars in Immunopathology

The Pathogenesis of IgA Nephropathy: What Is New and How Does It Change Therapeutic Approaches?

(2011) Jürgen Floege   AMERICAN JOURNAL OF KIDNEY DISEASES

Dysfunctions of the Iga system: a common link between intestinal and renal diseases

(2011) Christina Papista et al.   Cellular & Molecular Immunology

The pathogenesis of IgA nephropathy

(2011) Richard J Glassock   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation

(2011) Kazuo Takahashi et al.   JOURNAL OF PROTEOME RESEARCH

The Pathophysiology of IgA Nephropathy

(2011) H. Suzuki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch–Schönlein purpura nephritis

(2011) Krzysztof Kiryluk et al.   KIDNEY INTERNATIONAL

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy

(2011) Xue-Qing Yu et al.   NATURE GENETICS

Genome-wide association study identifies susceptibility loci for IgA nephropathy

(2011) Ali G Gharavi et al.   NATURE GENETICS

IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells

(2011) Jan Novak et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Recognition of Galactose-DeficientO-Glycans in the Hinge Region of IgA1 byN-Acetylgalactosamine-Specific Snail Lectins: A Comparative Binding Study

(2010) Michelle M. Gomes et al.   BIOCHEMISTRY

In vivo activation of complement by IgA in a rat model

(2010) R. K STAD et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

An acute model for IgA-mediated glomerular inflammation in rats induced by monoclonal polymeric rat IgA antibodies

(2010) R. K. STAD et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy

(2010) A. C. ALLEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy

(2010) Tatsuyuki Inoue et al.   CLINICAL IMMUNOLOGY

Galactose-Deficient IgA1 in African Americans with IgA Nephropathy: Serum Levels and Heritability

(2010) M. C. Hastings et al.   Clinical Journal of the American Society of Nephrology

Quantitation of Saccharide Compositions ofO-glycans by Mass Spectrometry of Glycopeptides and Its Application to Rheumatoid Arthritis

(2010) Yoshinao Wada et al.   JOURNAL OF PROTEOME RESEARCH

ClusteredO-Glycans of IgA1

(2010) Kazuo Takahashi et al.   MOLECULAR & CELLULAR PROTEOMICS

Glomerulonephritis after hematopoietic cell transplantation: IgA nephropathy with increased excretion of galactose-deficient IgA1

(2010) S. L. Hu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Down-regulation of core 1  1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1

(2010) K. Yamada et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

O-linked oligosaccharides of the IgA1 hinge region: roles of its aberrant structure in the occurrence and/or progression of IgA nephropathy

(2009) Yoshiyuki Hiki   Clinical and Experimental Nephrology

Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity

(2009) Hitoshi Suzuki et al.   JOURNAL OF CLINICAL INVESTIGATION

Macromolecular IgA1 taken from patients with familial IgA Nephropathy or their asymptomatic relatives have higher reactivity to mesangial cells in vitro

(2009) Ka Ying Tam et al.   KIDNEY INTERNATIONAL

Interaction between variants of two glycosyltransferase genes in IgA nephropathy

(2009) Li Zhu et al.   KIDNEY INTERNATIONAL

Gluten sensitivity in patients with IgA nephropathy

(2009) H. K. Smerud et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy

(2009) X. Lin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy

(2008) Ichiei Narita et al.   Clinical and Experimental Nephrology

IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1

(2008) Hitoshi Suzuki et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrant IgA1 Glycosylation Is Inherited in Familial and Sporadic IgA Nephropathy

(2008) A. G. Gharavi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

B-cell O-galactosyltransferase activity, and expression of O-glycosylation genes in bone marrow in IgA nephropathy

(2008) K.S. Buck et al.   KIDNEY INTERNATIONAL

No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients

(2008) F. Malycha et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Serum under-galactosylated IgA1 is increased in Japanese patients with IgA nephropathy

(2008) S. Shimozato et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Glomerular Response to IgA Deposition in IgA Nephropathy

(2008) Ivan C. Moura et al.   SEMINARS IN NEPHROLOGY

Secondary IgA Nephropathy

(2008) Shideh Pouria et al.   SEMINARS IN NEPHROLOGY

IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy

(2008) Jan Novak et al.   SEMINARS IN NEPHROLOGY