Review
Chemistry, Medicinal
Gigi Adam, Ana-Maria Adam, Silvia Robu, Valeriu Harabor, Anamaria Harabor, Aurel Nechita, Denisa Batir Marin, Ionela-Daniela Morariu, Oana Cioanca, Ingrid-Andrada Vasilache, Monica Hancianu
Summary: Chronic renal disorders have significant comorbidities and require complex therapeutic management. Perilla frutescens has emerged as a promising therapeutic option. This study reviews the therapeutic effects of PF extracts on various models of IgA nephropathy through a systematic review and meta-analysis.
Review
Immunology
Jurgen Floege, Thomas Rauen, Sydney C. W. Tang
Summary: IgA nephropathy is the most common type of glomerulonephritis in Asia and the Western world. Optimal supportive care and cautious use of immunosuppression are mainstay treatments. The controversy surrounding immunosuppression and the importance of patient characteristics in treatment plans should be carefully considered.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Urology & Nephrology
Alexandra Cambier, Patrick J. Gleeson, Lilia Abbad, Fanny Canesi, Jennifer da Silva, Julie Bex-Coudrat, Georges Deschenes, Olivia Boyer, Marion Rabant, Tim Ulinski, Julien Hogan, Michel Peuchmaur, Laureline Berthelot, Renato C. Monteiro
Summary: Childhood IgA nephropathy (IgAN) is a complex disease with unclear pathogenesis. This study found that soluble CD89 plays a crucial role in the development of childhood IgAN and may serve as a potential biomarker and therapeutic target.
KIDNEY INTERNATIONAL
(2022)
Review
Transplantation
Claudia Seikrit, Thomas Rauen, Eleni Stamellou, Jurgen Floege
Summary: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide with complex pathophysiology and clinical presentations. Early identification and individualized therapies are crucial for predicting disease progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Pediatrics
Sophie Schroda, Martin Pohl
Summary: Childhood and adolescence-onset IgA nephritis often leads to chronic glomerulonephritis with declining renal function. Evidence-based treatment recommendations for this age group are lacking. A study reported that corticosteroid treatment according to the German Society of Pediatric Nephrology recommendations resulted in significant improvement in most cases.
Article
Transplantation
Kamila Bednarova, Geir Mjoen, Petra Hruba, Istvan Modos, Ludek Voska, Marek Kollar, Ondrej Viklicky
Summary: This study developed a multivariable Cox model based on clinical data and a web-based nomogram to predict the recurrence and graft loss in kidney transplant recipients with IgA nephropathy (IgAN). The nomogram was externally validated and identified age, gender, retransplantation status, proteinuria, and C4d positivity as independent risk factors. The nomogram showed good predictive performance in identifying IgAN patients at risk for premature graft loss.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Cynthia J. Willey, Rosanna Coppo, Franz Schaefer, Malgorzata Mizerska-Wasiak, Mohit Mathur, Michaela J. Schultz
Summary: This study determined the incidence and prevalence of immunoglobulin A nephropathy (IgAN) in Europe by analyzing high-quality data from national registries. The annual IgAN incidence was found to be 0.76 per 100,000 people, and the overall prevalence was 2.53 per 10,000 people.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Dita Maixnerova, Petra Hruba, Michaela Neprasova, Kamila Bednarova, Janka Slatinska, Miloslav Suchanek, Marek Kollar, Jan Novak, Vladimir Tesar, Ondrej Viklicky
Summary: This study evaluated clinical parameters and histological findings of 313 IgAN patients, identifying risk factors affecting the course of IgAN after kidney transplantation, such as histological recurrence of IgAN, antibody-mediated rejection, and the onset of microscopic hematuria and proteinuria within 1 year after kidney transplant. These factors were associated with worse graft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Mineaki Kitamura, Salem Almaani, Bindu Challa, Mohankumar Doraiswamy, Isabelle Ayoub, Laura Biederman, Samir V. Parikh, Ana Molovic-Kokovic, Jason Benedict, Nilesh Mhaskar, Zeid J. Khitan, Sergey V. Brodsky, Tibor Nadasdy, Anjali A. Satoskar
Summary: Glomerulonephritis with crescents and IgA deposits poses a diagnostic and therapeutic challenge due to various possibilities. A study was conducted to assess the clinicopathologic features and follow-up of these cases.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
A. Saghar, G. Klaus, B. Trutnau, M. Koemhoff, H. J. Groene, S. Weber
Summary: Immunoglobulin A dominant postinfectious glomerulonephritis (IgA PIGN) is a rare medical condition in pediatric patients, characterized by severe renal failure, heavy proteinuria, hypertension, and hypocomplementemia. It is usually associated with staphylococcal infections and diabetes mellitus. This case report presents a 3-year-old girl with IgA PIGN who showed acute renal failure and had a good clinical outcome after steroid therapy.
Article
Medicine, General & Internal
Guizhen Yu, Jun Cheng, Yan Jiang, Heng Li, Xiayu Li, Jianghua Chen
Summary: This study found that in patients with IgAN, systolic blood pressure (SBP) was independently associated with kidney failure events. Lowering SBP from <140- <120 mm Hg was renoprotective.
FRONTIERS IN MEDICINE
(2022)
Article
Transplantation
Bjoern Peters, Joachim Beige, Justyna Siwy, Michael Rudnicki, Ralph Wendt, Alberto Ortiz, Ana Belen Sanz, Harald Mischak, Heather N. Reich, Salmir Nasic, Dana Mahmood, Anders Persson, Anders Fernstroem, Maria Weiner, Bernd Stegmayr
Summary: The urine-based classifier IgAN237 can predict disease progression in IgA nephropathy and is useful in guiding patient management.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Tae Ryom Oh, Hong Sang Choi, Se Won Oh, Jieun Oh, Dong Won Lee, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Summary: Hypertension is a risk factor in IgA nephropathy (IgAN), but the relationship between early blood pressure control and renal prognosis after IgAN diagnosis remains unclear. This study found that despite well-controlled hypertension in the first year after IgAN diagnosis, it still increased the risk of IgAN progression.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Urology & Nephrology
Suceena Alexander, Santosh Varughese, Rajanbabu Franklin, Grace Rebekah, Sanjeet Roy, Sabina Yusuf, Athul Thomas, Jeethu Joseph Eapen, Elenjickal Elias John, Anna T. Valson, Vinoi George David, Mohamed R. Daha, John Feehally, Jonathan Barratt, George T. John
Summary: Introduction: Glomerular Research And Clinical Experiments-IgA Nephropathy in Indians (GRACE-IgANI) is the first prospective South Asian IgA nephropathy cohort with pre-specified objectives, protocolized longitudinal follow-up, and extensive biosample collection. The study identified important predictors for composite outcome, including specific clinical variables and annual decline in estimated glomerular filtration rate (eGFR).
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Medicine, General & Internal
Anais Romero, Fanny Drieux, Arnaud Francois, Alexandra Dervaux, Xiao Li Xu, Dimitri Titeca-Beauport, Dominique Bertrand, Dominique Guerrot
Summary: In adults with IgA vasculitis, glomerular C4d positivity was associated with the severity of the kidney disease at presentation, but not with subsequent renal function deterioration.
FRONTIERS IN MEDICINE
(2021)