Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

(2021) Ines L. Paraiso et al.   Frontiers in Pharmacology

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

(2020) Sidhartha R. Sinha et al.   Cell Host & Microbe

Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Transcriptome in Mice

(2020) Joe Jongpyo Lim et al.   TOXICOLOGICAL SCIENCES

Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family

(2019) Ilias Lagkouvardos et al.   Microbiome

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

(2019) Matthew H. Foley et al.   PLoS Pathogens

Antimicrobial and inflammatory properties of South African clinical Lactobacillus isolates and vaginal probiotics

(2019) Emily Chetwin et al.   Scientific Reports

Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

(2019) A. B. Granado-Serrano et al.   Scientific Reports

PBDEs and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice

(2019) David K Scoville et al.   DRUG METABOLISM AND DISPOSITION

Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease

(2019) Almut Heinken et al.   Microbiome

Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice

(2019) Roberta Caruso et al.   Cell Reports

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors

(2018) Lyne Gagnon et al.   AMERICAN JOURNAL OF PATHOLOGY

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice

(2018) Cindy Yanfei Li et al.   DRUG METABOLISM AND DISPOSITION

In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion

(2018) Kateřina Pěnčíková et al.   ENVIRONMENTAL POLLUTION

Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100)

(2018) Jun Miyoshi et al.   Evidence-based Complementary and Alternative Medicine

The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota

(2018) Zoya Alteber et al.   IMMUNOLOGY AND CELL BIOLOGY

Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress

(2018) Da Hye Kim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Targeting the PXR–TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis

(2018) Kezhen Huang et al.   PEDIATRIC RESEARCH

Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A

(2018) Patrick M. Ketter et al.   mBio

Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo

(2018) Thibault Allain et al.   Frontiers in Microbiology

Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?

(2018) Thibault Allain et al.   Frontiers in Microbiology

Acclimation and Institutionalization of the Mouse Microbiota Following Transportation

(2018) Dan R. Montonye et al.   Frontiers in Microbiology

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

(2018) Ning Ma et al.   Frontiers in Immunology

Propionate-producing bacteria in the intestine may associate with skewed responses of IL10-producing regulatory T cells in patients with relapsing polychondritis

(2018) Jun Shimizu et al.   PLoS One

Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice

(2018) Zi-Lun Lai et al.   Scientific Reports

Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis

(2018) Joseph L Dempsey et al.   TOXICOLOGICAL SCIENCES

Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation

(2018) Mingyi Chen et al.   Frontiers in Microbiology

The immune response to Prevotella bacteria in chronic inflammatory disease

(2017) Jeppe Madura Larsen   IMMUNOLOGY

Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling

(2017) T Pallister et al.   INTERNATIONAL JOURNAL OF OBESITY

TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells

(2017) Natalia Yanguas-Casás et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PXR: More Than Just a Master Xenobiotic Receptor

(2017) Peter O. Oladimeji et al.   MOLECULAR PHARMACOLOGY

Meta-Analysis of Fecal Microbiota and Metabolites in Experimental Colitic Mice during the Inflammatory and Healing Phases

(2017) Toshifumi Osaka et al.   Nutrients

Comparative Genomic Analysis Reveals Ecological Differentiation in the Genus Carnobacterium

(2017) Christelle F. Iskandar et al.   Frontiers in Microbiology

Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model

(2017) Wenrui Wu et al.   Frontiers in Microbiology

Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages

(2017) L. M. Rocha-Ramírez et al.   Journal of Immunology Research

Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

(2017) Jose A. Caparrós-Martín et al.   Microbiome

To Group or Not to Group? Good Practice for Housing Male Laboratory Mice

(2017) Sarah Kappel et al.   Animals

PXR- and CAR-mediated herbal effect on human diseases

(2016) Chenshu Xu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

(2016) Julia Yue Cui et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Akkermansia muciniphilaimproves metabolic profiles by reducing inflammation in chow diet-fed mice

(2016) Shaoqian Zhao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hypocholesterolemic Properties and Prebiotic Effects of Mexican Ganoderma lucidum in C57BL/6 Mice

(2016) María E. Meneses et al.   PLoS One

Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

(2016) Josué Castro-Mejía et al.   Gastroenterology Research and Practice

Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4

(2016) Zhijuan Qiu et al.   Scientific Reports

Signatures of early frailty in the gut microbiota

(2016) Matthew A. Jackson et al.   Genome Medicine

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer

(2015) Justus Reunanen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Targeting xenobiotic receptors PXR and CAR in human diseases

(2015) Monimoy Banerjee et al.   DRUG DISCOVERY TODAY

Anticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34

(2015) Kyoung Jun Han et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

(2015) Felcy Pavithra Selwyn et al.   TOXICOLOGICAL SCIENCES

Effects of Vendor and Genetic Background on the Composition of the Fecal Microbiota of Inbred Mice

(2015) Aaron C. Ericsson et al.   PLoS One

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway

(2014) Wei Dou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

Secondary bile acids: an underrecognized cause of colon cancer

(2014) Hana Ajouz et al.   World Journal of Surgical Oncology

Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis

(2014) Tessalia Luerce et al.   Gut Pathogens

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Sex Differences in the Circadian Variation of Cytochrome P450 Genes and Corresponding Nuclear Receptors in Mouse Liver

(2013) Yuan-Fu Lu et al.   CHRONOBIOLOGY INTERNATIONAL

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

(2013) Morgan G I Langille et al.   NATURE BIOTECHNOLOGY

Flame Retardant BDE-47 Effectively Activates Nuclear Receptor CAR in Human Primary Hepatocytes

(2013) Tatsuya Sueyoshi et al.   TOXICOLOGICAL SCIENCES

Virulence factors ofEnterococcusstrains isolated from patients with inflammatory bowel disease

(2013) Edyta Golińska   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular cloning, characterization and comparison of bile salt hydrolases fromLactobacillus johnsoniiPF01

(2012) J.P. Chae et al.   JOURNAL OF APPLIED MICROBIOLOGY

Chronic Exposure to Rifaximin Causes Hepatic Steatosis in Pregnane X Receptor-Humanized Mice

(2012) Jie Cheng et al.   TOXICOLOGICAL SCIENCES

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

(2012) Jie Cheng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances

(2012) B. L. Williams et al.   mBio

Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease

(2012) Kirsty Brown et al.   Nutrients

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Lactobacillus paracaseiReduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis

(2011) Manuel Oliveira et al.   Clinical & Developmental Immunology

Responses of Gut Microbiota to Diet Composition and Weight Loss in Lean and Obese Mice

(2011) Yann Ravussin et al.   Obesity

Hepatic FXR: key regulator of whole-body energy metabolism

(2011) João Soeiro Teodoro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Interleukin-2 in the development and control of inflammatory disease

(2009) Katrina K. Hoyer et al.   IMMUNOLOGICAL REVIEWS

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Intestinal flora induces the expression of Cyp3a in the mouse liver

(2009) T. Toda et al.   XENOBIOTICA

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

IL-12 family members in experimental colitis

(2008) M F Neurath   Mucosal Immunology