Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes

Reduced skeletal muscle endurance and ventilatory efficiency during exercise in adult smokers without airflow obstruction

(2021) Ahmed Salama Sadaka et al.   JOURNAL OF APPLIED PHYSIOLOGY

LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations

(2020) Timothy A. Myers et al.   Frontiers in Genetics

Molecular Choreography of Acute Exercise

(2020) Kévin Contrepois et al.   CELL

Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

(2020) Timothy Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relationship between smoking and ALS: Mendelian randomisation interrogation of causality

(2020) Sarah Opie-Martin et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults

(2019) Karmel W. Choi et al.   JAMA Psychiatry

Smoking and amyotrophic lateral sclerosis: A mendelian randomization study

(2019) Yiqiang Zhan et al.   ANNALS OF NEUROLOGY

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

(2019) Sara Bandres‐Ciga et al.   ANNALS OF NEUROLOGY

Association Between Premorbid Body Mass Index and Amyotrophic Lateral Sclerosis: Causal Inference Through Genetic Approaches

(2019) Ping Zeng et al.   Frontiers in Neurology

The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public

(2019) Rick A.A. van der Spek et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis

(2019) Marie Ryan et al.   JAMA Neurology

Motor Neuron Susceptibility in ALS/FTD

(2019) Audrey M. G. Ragagnin et al.   Frontiers in Neuroscience

Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics

(2019) Ping Zeng et al.   BMC Medicine

Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE

(2018) Yann C. Klimentidis et al.   INTERNATIONAL JOURNAL OF OBESITY

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

(2018) Neil M Davies et al.   BMJ-British Medical Journal

Detecting individual and global horizontal pleiotropy in Mendelian randomization: a job for the humble heterogeneity statistic?

(2018) Jack Bowden et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The multistep hypothesis of ALS revisited

(2018) Adriano Chiò et al.   NEUROLOGY

Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study

(2018) Robyn E Wootton et al.   BMJ-British Medical Journal

GWAS identifies 14 loci for device-measured physical activity and sleep duration

(2018) Aiden Doherty et al.   Nature Communications

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

Interpreting findings from Mendelian randomization using the MR-Egger method

(2017) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

(2017) Russell L. McLaughlin et al.   Nature Communications

Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion

(2016) Jessica Houtz et al.   DEVELOPMENTAL CELL

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

(2016) Jack Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique

(2016) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

(2016) Wouter van Rheenen et al.   NATURE GENETICS

Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: A systematic review

(2016) Eleonora Lacorte et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

(2016) Yingchang Lu et al.   Nature Communications

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

(2016) Ceryl A. Harwood et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.

(2015) Mitchell J. Machiela et al.   BIOINFORMATICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

The widening spectrum of C9ORF72-related disease; genotype/phenotype correlations and potential modifiers of clinical phenotype

(2014) Johnathan Cooper-Knock et al.   ACTA NEUROPATHOLOGICA

Rare-Variant Association Analysis: Study Designs and Statistical Tests

(2014) Seunggeung Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epidemiological evidence that physical activity is not a risk factor for ALS

(2014) Bello Hamidou et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

(2014) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

Lifetime physical activity and the risk of amyotrophic lateral sclerosis

(2013) M. H. B. Huisman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles

(2013) J. Cooper-Knock et al.   NEUROLOGY

Occupational and leisure time physical activity in contrasting relation to ambulatory blood pressure

(2012) Els Clays et al.   BMC PUBLIC HEALTH

Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72

(2012) Johnathan Cooper-Knock et al.   BRAIN

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

(2012) Elisa Majounie et al.   LANCET NEUROLOGY

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

2011 Compendium of Physical Activities

(2011) BARBARA E. AINSWORTH et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Validation of the historical adulthood physical activity questionnaire (HAPAQ) against objective measurements of physical activity

(2010) Hervé Besson et al.   International Journal of Behavioral Nutrition and Physical Activity

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

(2010) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

ALS in Italian professional soccer players: The risk is still present and could be soccer-specific

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Reduced frequency of ALS in an ethnically mixed population: A population-based mortality study

(2009) T. Zaldivar et al.   NEUROLOGY